Results 1 to 10 of about 3,332 (192)

Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation. [PDF]

Mol Pharm
Clopidogrel, a frequently used prodrug, is converted to its active metabolite through the intermediate 2-oxo-clopidogrel by cytochrome P450 (CYP) enzymes, which accounts for only 5%-15% of its metabolism. Majority of the clopidogrel dose (85%-90%) is extensively hydrolyzed to its inactive metabolite, clopidogrel carboxylic acid by carboxylesterase 1 ...
Subash S, Singh DK, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Prasad B.   +8 more
europepmc   +3 more sources

Integrative analysis of adenosine-related RNA modifications defines molecular subtypes of bladder cancer and identifies CES1 as a driver of tumor progression and immunotherapy resistance. [PDF]

BMC Cancer
Huo X, Qi J, Zhu Y, Song H, Han W, Wang S.   +5 more
europepmc   +1 more source

Flumazenil reversal of remimazolam-induced sedation: a narrative review of safety, pharmacokinetics, and clinical considerations. [PDF]

Front Med (Lausanne)
Zhou Y, Wu W, Zhang Y, Peng Y, Jiang W, Zhang X, Ju F, Xie A.   +7 more
europepmc   +1 more source

Pharmacogenomics of direct oral anticoagulants: a systematic review and meta-analysis. [PDF]

Front Cardiovasc Med
Chai H, Huo J, Chen H.
europepmc   +1 more source

Niraparib PBPK modeling to predict optimal dosage in patients with hepatic impairment. [PDF]

Front Pharmacol
Pokladyuk A, Voronova V, Helmlinger G, Peskov K, Kosinsky Y.   +4 more
europepmc   +1 more source

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1. [PDF]

ACS Chem Neurosci
Digby Z, Diamond C, Wescott H, Smolak P, Thornton P, Lindsay N, Gabel CA, Clarke N, Watt AP.   +8 more
europepmc   +1 more source

Production of Novel Thermostable Esterases from <i>Thermus thermophilus</i> Strain ET-1 in <i>Escherichia coli</i> and <i>Thermus thermophilus</i> HB27 Using the Bifunctional Expression System pTGT-1 and Characterization of the Recombinant Enzymes. [PDF]

Int J Mol Sci
Valenzuela B, Cayo M, Solís-Cornejo F, Reyes MB, Palma I, Uribe E, Zamorano P.   +6 more
europepmc   +1 more source

Pharmacogenomic profiling of ABCB1 and CES1 in atrial fibrillation patients on dabigatran from a multiethnic Malaysian cohort. [PDF]

Sci Rep
Tan SSN, Sim EU, Jinam TA, Lim MSH, Chee CSM, Anchah L, Rosli SS, Sateng BBD, Gerunsin J, Tiong LL, Fong AYY.   +10 more
europepmc   +1 more source

Experimental and In Silico Approaches to Study Carboxylesterase Substrate Specificity. [PDF]

J Xenobiot
Ribone SR, Quevedo MA.
europepmc   +1 more source

Dose Recommendation of Remimazolam Tosilate for General Anesthesia in Children and Adolescents: Synergistic Combination of PopPK and PBPK Approaches. [PDF]

Pharmaceutics
Liang QY, Hu HH, Djebli N, Huang YY, Jiang H.   +4 more
europepmc   +1 more source