Results 1 to 10 of about 3,685 (179)

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c [PDF]

Cells
Increased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
Rajakumar Selvaraj, Jihong Lian, Russell Watts, Randal Nelson, Michael F. Saikali, Carolyn L. Cummins, Richard Lehner   +6 more
doaj   +6 more sources

Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy [PDF]

JCI Insight, 2023
Hepatocellular carcinoma (HCC) is the most common lethal form of liver cancer. Apart from surgical removal and transplantation, other treatments have not yet been well established for patients with HCC.
Gang Li, Xin Li, Iqbal Mahmud, Jazmin Ysaguirre, Baharan Fekry, Shuyue Wang, Bo Wei, Kristin L. Eckel-Mahan, Philip L. Lorenzi, Richard Lehner, Kai Sun   +10 more
doaj   +4 more sources

Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents With Potential Inhibitory Effect on Human CES1 [PDF]

Molecules, 2019
The human carboxylesterase 1 (CES1), responsible for the biotransformation of many diverse therapeutic agents, may contribute to the occurrence of adverse drug reactions and therapeutic failure through drug interactions.
Kristian Linnet, Henrik Berg Rasmussen, Eliane Briand   +2 more
exaly   +4 more sources

Association Between CES1 rs2244613 and the Pharmacokinetics and Safety of Dabigatran: Meta-Analysis and Quantitative Trait Loci Analysis [PDF]

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Haoyi Weng
exaly   +4 more sources

The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients With Arterial Hypertension

Journal of Personalized Medicine, 2022
The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). Previous studies show that variant rs71647871 in the CES1 gene affects the pharmacokinetics of enalapril on liver samples as well as healthy volunteers.
Tatiana Nasedkina, Anna Ikonnikova
exaly   +4 more sources

CES1 and SLC6A2 Genetic Variants As Predictors of Response To Methylphenidate in Autism Spectrum Disorders [PDF]

Pharmacogenomics and Personalized Medicine, 2022
Marta H Hernandez1,2 *, Valentin Bote3 *, Alexandre Serra-LLovich,1 Marc Cendros,1,4 Juliana Salazar,5 Conxita Mestres,2 Silvina Guijarro,3 Aida Alvarez,3 Cristina Lamborena,3 Iria Mendez,3 Bernardo Sanchez,3 Amaia Hervas,3 Maria J Arranz1,2 ...
Hernandez MH, Bote V, Serra-LLovich A, Cendros M, Salazar J, Mestres C, Guijarro S, Alvarez A, Lamborena C, Mendez I, Sanchez B, Hervas A, Arranz MJ   +12 more
doaj   +7 more sources

The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients With Atrial Fibrillation Treated With DOAC

Genes, 2023
Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify the influence of polymorphisms of the genes encoding P-glycoprotein (ABCB1) and carboxylesterase 1 (CES1) on the variability of plasma concentrations of DOACs in Kazakhstani patients with ...
Ainur Akilzhanova
exaly   +4 more sources

Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation [PDF]

Molecular Pharmaceutics
Clopidogrel, a frequently used prodrug, is converted to its active metabolite through the intermediate 2-oxo-clopidogrel by cytochrome P450 (CYP) enzymes, which accounts for only 5%-15% of its metabolism. Majority of the clopidogrel dose (85%-90%) is extensively hydrolyzed to its inactive metabolite, clopidogrel carboxylic acid by carboxylesterase 1 ...
Dilip Kumar Singh, Robert S Jones, Bhagwat Prasad   +2 more
exaly   +4 more sources

Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population [PDF]

Caspian Journal of Internal Medicine
Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran.
Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova   +10 more
doaj   +4 more sources

The Pharmacokinetics of Enalapril in Relation toCES1Genotype in Healthy Danish Volunteers [PDF]

Basic & Clinical Pharmacology & Toxicology, 2017
AbstractThis study investigated the influence of variations in the carboxylesterase 1 gene (CES1)on the pharmacokinetics of enalapril. Forty‐three healthy, Danish, Caucasian volunteers representing different pre‐defined genotypes each received 10 mg of enalapril.
Stage, Claus, Jürgens, Gesche, Guski, Louise Schow, Thomsen, Ragnar, Bjerre, Ditte, Ferrero-Miliani, Laura, Lyauk, Yassine Kamal, Berg Rasmussen, Henrik, Dalhoff, Kim   +8 more
openaire   +4 more sources