CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c [PDF]
CellsIncreased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
Rajakumar Selvaraj +6 more
doaj +5 more sources
Associations between CES1 variants and dosing and adverse effects in children taking methylphenidate
Frontiers in Pediatrics, 2023 BackgroundMethylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders to the medication.
Jacob Brown +2 more
exaly +5 more sources
Journal of Pharmaceutical Analysis, 2020 In traditional Chinese medicine herbs (TCM), including Radix Salviae Miltiorrhizae (Danshen), Radix Puerariae Lobatae (Gegen), Radix Angelicae Sinensis (Danggui), and Rhizoma Chuanxiong (Chuanxiong) are widely used for the prevention and treatment of ...
Yufeng Zhang, Ling Yang, Zhong Zuo
exaly +3 more sources
Frontiers in Cardiovascular Medicine, 2022 ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Xianbo Zuo +2 more
exaly +3 more sources
Molecules, 2019 The human carboxylesterase 1 (CES1), responsible for the biotransformation of many diverse therapeutic agents, may contribute to the occurrence of adverse drug reactions and therapeutic failure through drug interactions.
KRISTIAN Linnet +2 more
exaly +3 more sources
The role of ABCB1 and CES1 genotypes on the efficacy and safety of dabigatran: a systematic review and meta-analysis [PDF]
Human GenomicsIntroduction : Dabigatran is a direct oral anticoagulant associated with a high incidence of gastrointestinal bleeding, which presents a significant clinical concern.
Weam Aldiban +9 more
doaj +2 more sources
Hypercholesterolemia and the role of lipid metabolism gene CES1 in immune infiltration promote central nervous system relapse in acute myeloid leukemia [PDF]
Frontiers in ImmunologyBackgroundAlterations in multiple lipid metabolism pathways are associated with cancer progression. However, the relationship between lipid metabolism and central nervous system (CNS) relapse in acute myeloid leukemia (AML) remains unclear.MethodsWe ...
Wanwan Bao +8 more
doaj +2 more sources
Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization [PDF]
CPT: Pharmacometrics & Systems PharmacologyAzathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning ...
Zhijun Xie +4 more
doaj +2 more sources
NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans [PDF]
Frontiers in GeneticsIntroductionGenetic variation in genes coding for enzymes metabolising antihypertensive drugs, may affect the efficacy of angiotensin converting enzyme (ACE) inhibitors such as enalapril, potentially leading to resistant hypertension (RHTN).
Jonathan N. Katsukunya +17 more
doaj +2 more sources
Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism
Acta Pharmaceutica Sinica B, 2023 The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout ...
Changpei Gan +15 more
doaj +1 more source