Results 31 to 40 of about 3,685 (179)

Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. [PDF]

PLoS ONE, 2014
Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke.
Jiesi Xu, Liya Yin, Yang Xu, Yuanyuan Li, Munaf Zalzala, Gang Cheng, Yanqiao Zhang   +6 more
doaj   +1 more source

Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population

Scientific Reports, 2021
A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol.
Bing bing Chen, Jian hui Yan, Jing Zheng, He wei Peng, Xiao ling Cai, Xin ting Pan, Hui quan Li, Qi zhu Hong, Xian-E Peng   +8 more
doaj   +1 more source

Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function. [PDF]

PLoS ONE, 2013
CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes.
Martin Friedrichsen, Pernille Poulsen, Jørgen Wojtaszewski, Peter Riis Hansen, Allan Vaag, Henrik Berg Rasmussen   +5 more
doaj   +1 more source

Carboxylesterase1/Esterase-x regulates chylomicron production in mice. [PDF]

PLoS ONE, 2012
Elevated postprandial plasma triacylglycerol (TG) concentrations are commonly associated with obesity and the risk of cardiovascular disease. Dietary fat contributes to this condition through the production of chylomicrons.
Ariel D Quiroga, Jihong Lian, Richard Lehner   +2 more
doaj   +1 more source

A prognostic index model for assessing the prognosis of ccRCC patients by using the mRNA expression profiles of AIF1L, SERPINC1 and CES1 [PDF]

Journal of Men's Health, 2022
Background: Kidney carcinoma is a major cause of carcinoma-related death, with the prognosis for advanced or metastatic renal cell carcinoma still very poor.
Song Zheng, Zihao Chen, Jianhui Chen, Rong Liu, Mei Song, Angchao Ye, Shaoxing Zhu, Hua Wang, Zongping Wang, Fangyin Li, Jinhan Lou, Yaping Chen, Fang Fang, Chunmei Wen, Jing Zhang, Bilan Xue, He Wang, Jianmin Lou, Weizhong Cai, Yaoyao Wu, Yipeng Xu   +20 more
doaj   +1 more source

Enhancer RNA lnc-CES1-1 inhibits decidual cell migration by interacting with RNA-binding protein FUS and activating PPARγ in URPL

Molecular Therapy: Nucleic Acids, 2021
Unexplained recurrent pregnancy loss (URPL) is a significant reproductive health issue, affecting approximately 5% of pregnancies. Enhancer RNAs (eRNAs) have been reported to play important roles during embryo development and may be related to URPL.
Zhenyao Huang, Hao Yu, Guizhen Du, Li Han, Xiaomin Huang, Dan Wu, Xiumei Han, Yankai Xia, Xinru Wang, Chuncheng Lu   +9 more
doaj   +1 more source

Hepatocyte‐Specific Expression of Human Carboxylesterase 1 Attenuates Diet‐Induced Steatohepatitis and Hyperlipidemia in Mice

Hepatology Communications, 2020
Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions.
Yanyong Xu, Yingdong Zhu, Fathima Cassim Bawa, Shuwei Hu, Xiaoli Pan, Liya Yin, Yanqiao Zhang   +6 more
doaj   +1 more source

Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors. [PDF]

PLoS ONE, 2016
BACKGROUND:Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure ...
Karl Emil Nelveg-Kristensen, Peter Bie, Laura Ferrero, Ditte Bjerre, Niels E Bruun, Martin Egfjord, Henrik B Rasmussen, Peter R Hansen, INDICES Consortium   +8 more
doaj   +1 more source

Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity

Frontiers in Nutrition, 2022
BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia, Sirong Shi, Bolun Cheng, Shiqiang Cheng, Li Liu, Peilin Meng, Xuena Yang, Xiaoge Chu, Yan Wen, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Cannabinoid Inhibition of Carboxylesterase 1 (CES1)

The FASEB Journal, 2019
The increasing use of cannabis for both medical indications and on a recreational basis poses a potential for drug interactions between cannabis or one or more of its constituents and conventional therapeutic agents. Although significant efforts have been made to assess the in vitro and
Yuli Qian, John S. Markowitz
openaire   +1 more source