Results 31 to 40 of about 2,904 (163)
The impact ofCES1genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects [PDF]
British Journal of Clinical Pharmacology, 2017 AimsThis study investigated the influence ofCES1variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate.MethodsCES1genotype was obtained from 200 healthy Danish Caucasian volunteers.
Stage, Claus +8 more
openaire +3 more sources
Regulation of carboxylesterase 1 (CES1) in human adipose tissue
Biochemical and Biophysical Research Communications, 2009 Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n=78 pairs, P=8.7x10(-18)) and brothers (n=12 pairs, P=0.048).
Jernås, Margareta +9 more
openaire +2 more sources
Engineering, 2022 Accurately assessing and tracking the progression of liver-specific injury remains a major challenge in the field of biomarker research. Here, we took a retrospective validation approach built on the mutuality between serum and tissue biomarkers to ...
Qiusha Pan +10 more
doaj +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender [PDF]
Biochemical Pharmacology, 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). A recent genome-wide association study reported that the CES1 single nucleotide polymorphisms (SNPs) rs2244613 and rs8192935 were associated ...
Jian, Shi +6 more
openaire +2 more sources
BMC Evolutionary Biology, 2008 Background Carboxylesterases (CES) perform diverse metabolic roles in mammalian organisms in the detoxification of a broad range of drugs and xenobiotics and may also serve in specific roles in lipid, cholesterol, pheromone and lung surfactant metabolism.
Chan Jeannie +4 more
doaj +1 more source
The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans. [PDF]
PLoS ONE, 2017 Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease
Jaeseong Oh +7 more
doaj +1 more source
Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
doaj +1 more source
Медицинский совет, 2020 Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka +12 more
doaj +1 more source
Journal of Lipid Research, 2012 Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It
Dongfang Yang +7 more
doaj +1 more source