Results 31 to 40 of about 6,102 (207)
Frontiers in Nutrition, 2022 BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia +10 more
doaj +1 more source
Cannabinoid Inhibition of Carboxylesterase 1 (CES1)
The FASEB Journal, 2019 The increasing use of cannabis for both medical indications and on a recreational basis poses a potential for drug interactions between cannabis or one or more of its constituents and conventional therapeutic agents. Although significant efforts have been made to assess the in vitro and
Yuli Qian, John S. Markowitz
openaire +1 more source
Engineering, 2022 Accurately assessing and tracking the progression of liver-specific injury remains a major challenge in the field of biomarker research. Here, we took a retrospective validation approach built on the mutuality between serum and tissue biomarkers to ...
Qiusha Pan +10 more
doaj +1 more source
Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr −/− mice [PDF]
Scientific Reports, 2017 AbstractAtherosclerotic cardiovascular disease is a leading cause of death in the western world. Increased plasma triglyceride and cholesterol levels are major risk factors for this disease. Carboxylesterase 1 (Ces1/Ces1g) has been shown to play a role in metabolic control.
Jiesi Xu +4 more
openaire +2 more sources
Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system [PDF]
, 2019 Background: Remimazolam is an ultra-short acting benzodiazepine under development for procedural sedation and general anesthesia. It is hydrolyzed by CES1 to an inactive metabolite (CNS7054).
Damm, Georg +8 more
core +1 more source
Regulation of carboxylesterase 1 (CES1) in human adipose tissue
Biochemical and Biophysical Research Communications, 2009 Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n=78 pairs, P=8.7x10(-18)) and brothers (n=12 pairs, P=0.048).
Jernås, Margareta +9 more
openaire +2 more sources
The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans. [PDF]
PLoS ONE, 2017 Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease
Jaeseong Oh +7 more
doaj +1 more source
Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus [PDF]
Pharmacogenetics and Genomics, 2016 CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Previous studies have reported a genomic translocation of the 5' region from the poorly expressed pseudogene CES1P1, to CES1, yielding the structural variant CES1VAR.
Jonathan C, Sanford +6 more
openaire +2 more sources
Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC
European Journal of Pharmaceutical Sciences, 2021 The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and toxicokinetic studies of new chemical entities. Species differences in drug metabolism are obstacles for the extrapolation of animal data to humans. This study aimed to characterize hydrolase activities for typical compounds by cynomolgus monkey liver microsomes and ...
Shiori, Honda +5 more
openaire +2 more sources
Modal shift for New Zealand shippers for various policy scenarios [PDF]
, 2017 Increasing transport problems caused by high dependency on road transport, has brought us to investigate various policy scenarios to promote a greater use of rail and coastal transport for freight transport in New Zealand.
Kim, Hyun-Chan +2 more
core +1 more source