Results 11 to 20 of about 3,685 (179)

Regulation of carboxylesterase 1 (CES1) in human adipose tissue

Biochemical and Biophysical Research Communications, 2009
Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n=78 pairs, P=8.7x10(-18)) and brothers (n=12 pairs, P=0.048).
Jernås, Margareta, Olsson, Bob, Arner, Peter, Jacobson, Peter, Sjöström, Lars, Walley, Andrew, Froguel, Philippe, McTernan, Philip G., Hoffstedt, Johan, Carlsson, Lena M.S.   +9 more
openaire   +3 more sources

Rapid Bioluminescence Assay for Monitoring Rat CES1 Activity and Its Alteration by Traditional Chinese Medicines

Journal of Pharmaceutical Analysis, 2020
In traditional Chinese medicine herbs (TCM), including Radix Salviae Miltiorrhizae (Danshen), Radix Puerariae Lobatae (Gegen), Radix Angelicae Sinensis (Danggui), and Rhizoma Chuanxiong (Chuanxiong) are widely used for the prevention and treatment of ...
Yufeng Zhang, Ling Yang, Zhong Zuo
exaly   +3 more sources

Analytical Validation and Preliminary Clinical Evaluation of Plasma Carboxylesterase 1 for Ultrasound-Defined Hepatic Steatosis [PDF]

Diagnostics
Background/Objectives: Steatotic liver disease (SLD) is a global health priority, increasing the demand for accessible circulating biomarkers. Carboxylesterase 1 (CES1) plays a key role in hepatic lipid metabolism, but its clinical utility as a plasma ...
Makito Tanaka, Shingo Tanaka, Kayoko Ochi, Ryo Kobayashi, Ryosei Murai, Satoshi Takahashi   +5 more
doaj   +2 more sources

Individualization of Treatments with Drugs Metabolized by CES1: Combining Genetics and Metabolomics

Pharmacogenomics, 2015
CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic compounds including several essential and commonly used drugs. The individual variation in the efficacy and tolerability of many drugs metabolized by CES1 is considerable. Hence, there is a large interest in individualizing the treatment with these drugs. The present
Rasmussen, H.B., Bjerre, D., Linnet, K., Juergens, G., Dalhoff, K., Stefansson, H., Hankemeier, T., Kaddurah-Daouk, R., Taboureau, O., Brunak, S., Houmann, T., Jeppesen, P., Pagsberg, A.K., Plessen, K., Dyrborg, J., Hansen, P.R., Hansen, P.E., Hughes, T., Werge, T.   +18 more
openaire   +5 more sources

The impact ofCES1genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects [PDF]

British Journal of Clinical Pharmacology, 2017
AimsThis study investigated the influence ofCES1variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate.MethodsCES1genotype was obtained from 200 healthy Danish Caucasian volunteers.
Stage, Claus, Jürgens, Gesche, Guski, Louise Schow, Thomsen, Ragnar, Bjerre, Ditte, Ferrero-Miliani, Laura, Lyauk, Yassine Kamal, Berg Rasmussen, Henrik, Dalhoff, Kim   +8 more
openaire   +4 more sources

Reappraisal of the Genetic Diversity and Pharmacogenetic Assessment of CES1

Pharmacogenomics, 2017
The CES1 gene encodes a hydrolase that metabolizes important drugs. Variants generated by exchange of segments with CES1P1 complicate genotyping of CES1. Using a highly specific procedure we examined DNA samples from 200 Caucasians and identified 46 single nucleotide variants (SNVs) in CES1 and 21 SNVs in CES1A2, a hybrid composed of CES1 and CES1P1 ...
Ferrero-Miliani, Laura, Bjerre, Ditte, Stage, Claus, Madsen, Majbritt Busk, Jürgens, Gesche, Dalhoff, Kim Peder, Rasmussen, Henrik Berg, Linnet, Kristian, Thomsen, Ragnar, Stefansson, Hreinn, Hankemeier, Thomas, Kaddurah-Daouk, Rima, Brunak, Søren, Taboureau, Olivier, Nzabonimpa, Grace Shema, Houmann, Tine, Jeppesen, Pia, Kaalund-Jørgensen, Kristine, Hansen, Peter Riis, Kristensen, Karl Emil, Pagsberg, Anne Katrine, Plessen, Kerstin Jessica, Hansen, Poul Erik; id_orcid 0000-0003-4751-9910, Werge, Thomas, Dyrborg, Jørgen, Lauritzen, Maj Britt, Hughes, Timothy, Lyauk, Yassine Kamal   +27 more
openaire   +5 more sources

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects

Pharmacogenomics and Personalized Medicine, 2021
Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y, Yang C, Qi W, Pei Z, Xue W, Zhu H, Dong M, Guo Y, Cong D, Wang F   +9 more
doaj   +4 more sources

Integrated Transcriptomics and Lipidomics Identify CES1-Mediated Maladaptive Lipolysis as a Key Target of Hyperlipidemic Acute Pancreatitis [PDF]

Metabolites
Background: Hyperlipidemic acute pancreatitis (HAP) is a severe disease driven by systemic lipid overload. While free fatty acids (FFAs) are known to mediate pancreatic lipotoxicity, the intracellular enzymatic mechanisms generating these toxic lipid ...
Jiayu Liu, Yunshu Zhang, Xingchi Jiang, Haocheng Xue, Peiyuan Yin   +4 more
doaj   +2 more sources

IMPACT OF ABCB1 AND CES1 GENETIC POLYMORPHISMS ON TROUGH STEADY-STATE DABIGATRAN CONCENTRATIONS IN PATIENTS AFTER ENDOPROSTHESIS OF KNIFE JOIN

Атеротромбоз, 2018
Oral anticoagulants are widely used to prevent thromboembolic events in patients following total knee arthroplasty [1]. The genetic characteristics of patients affect the efficacy and safety of anticoagulants [2].
D. A. Sychev, A. N. Levanov, T. V. Shelekhova, P. O. Bochkov, N. Р. Denisenko, K. A. Ryzhikova, K. В. Mirzaev, E. A. Grishina, M. A. Gavrilov   +8 more
doaj   +3 more sources

Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr −/− mice [PDF]

Scientific Reports, 2017
AbstractAtherosclerotic cardiovascular disease is a leading cause of death in the western world. Increased plasma triglyceride and cholesterol levels are major risk factors for this disease. Carboxylesterase 1 (Ces1/Ces1g) has been shown to play a role in metabolic control.
Jiesi Xu, Yang Xu, Yanyong Xu, Liya Yin, Yanqiao Zhang   +4 more
openaire   +3 more sources