Results 11 to 20 of about 3,332 (192)
CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c [PDF]
CellsIncreased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
Rajakumar Selvaraj +6 more
doaj +6 more sources
JCI Insight, 2023 Hepatocellular carcinoma (HCC) is the most common lethal form of liver cancer. Apart from surgical removal and transplantation, other treatments have not yet been well established for patients with HCC.
Gang Li +10 more
doaj +5 more sources
Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1 [PDF]
Molecules, 2019 The human carboxylesterase 1 (CES1), responsible for the biotransformation of many diverse therapeutic agents, may contribute to the occurrence of adverse drug reactions and therapeutic failure through drug interactions.
Eliane Briand +2 more
exaly +4 more sources
Frontiers in Cardiovascular Medicine, 2022 ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Zhang Zhu, Zubiaur Pablo, Zuo Xianbo
exaly +4 more sources
Атеротромбоз, 2018 Oral anticoagulants are widely used to prevent thromboembolic events in patients following total knee arthroplasty [1]. The genetic characteristics of patients affect the efficacy and safety of anticoagulants [2].
D. A. Sychev +8 more
doaj +8 more sources
CES1 and SLC6A2 Genetic Variants As Predictors of Response To Methylphenidate in Autism Spectrum Disorders [PDF]
Pharmacogenomics and Personalized Medicine, 2022 Marta H Hernandez1,2 *, Valentin Bote3 *, Alexandre Serra-LLovich,1 Marc Cendros,1,4 Juliana Salazar,5 Conxita Mestres,2 Silvina Guijarro,3 Aida Alvarez,3 Cristina Lamborena,3 Iria Mendez,3 Bernardo Sanchez,3 Amaia Hervas,3 Maria J Arranz1,2 ...
Hernandez MH +12 more
doaj +7 more sources
Regulation of carboxylesterase 1 (CES1) in human adipose tissue
Biochemical and Biophysical Research Communications, 2009 Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n=78 pairs, P=8.7x10(-18)) and brothers (n=12 pairs, P=0.048).
Jernås, Margareta +9 more
openaire +3 more sources
The Pharmacokinetics of Enalapril in Relation toCES1Genotype in Healthy Danish Volunteers [PDF]
Basic & Clinical Pharmacology & Toxicology, 2017 AbstractThis study investigated the influence of variations in the carboxylesterase 1 gene (CES1)on the pharmacokinetics of enalapril. Forty‐three healthy, Danish, Caucasian volunteers representing different pre‐defined genotypes each received 10 mg of enalapril.
Stage, Claus +8 more
openaire +4 more sources
The impact ofCES1genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects [PDF]
British Journal of Clinical Pharmacology, 2017 AimsThis study investigated the influence ofCES1variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate.MethodsCES1genotype was obtained from 200 healthy Danish Caucasian volunteers.
Stage, Claus +8 more
openaire +4 more sources
Journal of Pharmaceutical Analysis, 2020 In traditional Chinese medicine herbs (TCM), including Radix Salviae Miltiorrhizae (Danshen), Radix Puerariae Lobatae (Gegen), Radix Angelicae Sinensis (Danggui), and Rhizoma Chuanxiong (Chuanxiong) are widely used for the prevention and treatment of ...
Li-Wei Zou, Yufeng Zhang, Ziwei Li
exaly +3 more sources