Results 41 to 50 of about 3,685 (179)
Comparative clinical and economic evaluation of pharmacogenetic testing application for dabigatran in patients with atrial fibrillation [PDF]
Терапевтический архив, 2019 Aim. To evaluate the clinical and economic feasibility of pharmacogenetic testing (PGT) for dabigataran etexilate administration in the treatment of atrial fibrillation (AF) without valve in comparison with tactics without pharmacogenetic testing ...
Sh P Abdullaev, K B Mirzaev, D A Sychev
doaj +1 more source
Engineering, 2022 Accurately assessing and tracking the progression of liver-specific injury remains a major challenge in the field of biomarker research. Here, we took a retrospective validation approach built on the mutuality between serum and tissue biomarkers to ...
Qiusha Pan +10 more
doaj +1 more source
CES1 regulates postprandial levels.
, 2014 (A–H) C57BL/6 mice were injected with Ad-shLacZ or Ad-shCes1. After 5 days, mice were fasted for 16 h followed by gavage with saline or glucose (8 g/kg) (n = 6 mice per group).
Yang Xu (178421) +6 more
core +1 more source
Novel Approach for CES1 Genotyping: Integrating Single Nucleotide Variants and Structural Variation [PDF]
Pharmacogenomics, 2018 Development of a specific procedure for genotyping of CES1A1 (CES1) and CES1A2, a hybrid of CES1A1 and the pseudogene CES1P1.The number of CES1A1 and CES1A2 copies and that of CES1P1 were determined using real-time PCR. Long range PCRs followed by secondary PCRs allowed sequencing of single nucleotide variants in CES1A1 and CES1A2.A procedure ...
Ditte, Bjerre +2 more
openaire +3 more sources
Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC
European Journal of Pharmaceutical Sciences, 2021 The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and toxicokinetic studies of new chemical entities. Species differences in drug metabolism are obstacles for the extrapolation of animal data to humans. This study aimed to characterize hydrolase activities for typical compounds by cynomolgus monkey liver microsomes and ...
Shiori, Honda +5 more
openaire +2 more sources
Intestinal Ces1/Es-x expression is regulated by nutritional status.
, 2013 (A) Intestinal Ces1/Es-x protein expression in different nutritional states. Mice were fasted for 24 h and refed for 6 h. Fasted and refed mice were euthanized at 8:00 P.M.
Ariel D. Quiroga (300200) +2 more
core +1 more source
BMC Evolutionary Biology, 2008 Background Carboxylesterases (CES) perform diverse metabolic roles in mammalian organisms in the detoxification of a broad range of drugs and xenobiotics and may also serve in specific roles in lipid, cholesterol, pheromone and lung surfactant metabolism.
Chan Jeannie +4 more
doaj +1 more source
The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans. [PDF]
PLoS ONE, 2017 Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease
Jaeseong Oh +7 more
doaj +1 more source
Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
doaj +1 more source
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender [PDF]
Biochemical Pharmacology, 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). A recent genome-wide association study reported that the CES1 single nucleotide polymorphisms (SNPs) rs2244613 and rs8192935 were associated ...
Jian, Shi +6 more
openaire +2 more sources