Results 51 to 60 of about 3,332 (192)
The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation [PDF]
BMC Cardiovascular Disorders, 2022 Aims: This study aimed to analyze associations between genetic variants and plasma concentrations along with clinical outcomes in dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods: We conducted a prospective study and enrolled NVAF patients treated with dabigatran in the real world.
Zhu Zhu +7 more
openaire +3 more sources
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
The role of CES1 gene polymorphisms in clinical medicine
, 2023 Dabigatran je aktivni oblik prolijeka dabigatraneteksilata koji pripada skupini direktnih oralnih antikoagulansa (DOAK) te djeluje kao izravni oralni inhibitor trombina.
Prpić, Ivana
core +2 more sources
CES1 regulates postprandial levels.
, 2014 (A–H) C57BL/6 mice were injected with Ad-shLacZ or Ad-shCes1. After 5 days, mice were fasted for 16 h followed by gavage with saline or glucose (8 g/kg) (n = 6 mice per group).
Yang Xu (178421) +6 more
core +1 more source
Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
doaj +1 more source
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender [PDF]
Biochemical Pharmacology, 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). A recent genome-wide association study reported that the CES1 single nucleotide polymorphisms (SNPs) rs2244613 and rs8192935 were associated ...
Jian, Shi +6 more
openaire +2 more sources
Intestinal Ces1/Es-x expression is regulated by nutritional status.
, 2013 (A) Intestinal Ces1/Es-x protein expression in different nutritional states. Mice were fasted for 24 h and refed for 6 h. Fasted and refed mice were euthanized at 8:00 P.M.
Ariel D. Quiroga (300200) +2 more
core +1 more source
Медицинский совет, 2020 Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka +12 more
doaj +1 more source
, 2022 ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Xianbo Zuo (410580) +11 more
core +1 more source
BMC Evolutionary Biology, 2008 Background Carboxylesterases (CES) perform diverse metabolic roles in mammalian organisms in the detoxification of a broad range of drugs and xenobiotics and may also serve in specific roles in lipid, cholesterol, pheromone and lung surfactant metabolism.
Chan Jeannie +4 more
doaj +1 more source