Results 51 to 60 of about 3,685 (179)

Image_2_Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis.jpg

, 2022
ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Xianbo Zuo (410580), Peiran Yang (11746717), Chen Wang (88408), Yu Zhang (12946), Anna-Leena Vuorinen (661307), Zhenguo Zhai (340625), Zhu Zhang (629872), Yuting Qiu (5505692), Haobo Li (1454857), Guohui Fan (5195828), Haoyi Weng (11093583), Pablo Zubiaur (7285734)   +11 more
core   +1 more source

Safety of dabigatran in patients with atrial fibrillation and chronic kidney disease: pharmacokinetic and pharmacogenetic aspects

Медицинский совет, 2020
Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka, P. O. Bochkov, K. A. Akmalova, R. V. Shevchenko, P. M. Krupenin, V. V. Kogay, A. I. Listratov, A. S. Krainyaya, D. A. Napalkov, O. S. Gurinovich, A. A. Sokolova, V. V. Fomin, D. A. Sychev   +12 more
doaj   +1 more source

Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus [PDF]

Pharmacogenetics and Genomics, 2016
CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Previous studies have reported a genomic translocation of the 5' region from the poorly expressed pseudogene CES1P1, to CES1, yielding the structural variant CES1VAR.
Jonathan C, Sanford, Xinwen, Wang, Jian, Shi, Elizabeth S, Barrie, Danxin, Wang, Hao-Jie, Zhu, Wolfgang, Sadee   +6 more
openaire   +2 more sources

Association between CES1 mRNA expression level in adipose tissue and measures of glucose and lipid metabolism.

, 2013
The statistical model is: ln(response variable) = age+sex+BMI+CES1 mRNA level. The regression coefficient expresses the change in the response variable associated with a doubling of CES1 mRNA level from its average. CES1: carboxylesterase 1 gene; HOMA-IR:
Peter Riis Hansen (283251), Henrik Berg Rasmussen (384275), Martin Friedrichsen (113408), Jørgen Wojtaszewski (384274), Allan Vaag (28300), Pernille Poulsen (28289)   +5 more
core   +1 more source

Image_1_Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis.jpg

, 2022
ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Xianbo Zuo (410580), Peiran Yang (11746717), Chen Wang (88408), Yu Zhang (12946), Anna-Leena Vuorinen (661307), Zhenguo Zhai (340625), Zhu Zhang (629872), Yuting Qiu (5505692), Haobo Li (1454857), Guohui Fan (5195828), Haoyi Weng (11093583), Pablo Zubiaur (7285734)   +11 more
core   +1 more source

Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump

Journal of Lipid Research, 2012
Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It
Dongfang Yang, Jian Yang, Deshi Shi, Da Xiao, Yi-Tzai Chen, Chris Black, Ruitang Deng, Bingfang Yan   +7 more
doaj   +1 more source

Table_1_Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis.docx

, 2022
ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Xianbo Zuo (410580), Peiran Yang (11746717), Chen Wang (88408), Yu Zhang (12946), Anna-Leena Vuorinen (661307), Zhenguo Zhai (340625), Zhu Zhang (629872), Yuting Qiu (5505692), Haobo Li (1454857), Guohui Fan (5195828), Haoyi Weng (11093583), Pablo Zubiaur (7285734)   +11 more
core   +1 more source

Effect of selected variables on CES1 mRNA expression level in adipose tissue.

, 2013
The statistical model is: ln(CES1 mRNA level) = age+gender+BMI. The regression coefficient expresses the change in the response variable associated with an increase of one unit in an explanatory variable.
Peter Riis Hansen (283251), Henrik Berg Rasmussen (384275), Martin Friedrichsen (113408), Jørgen Wojtaszewski (384274), Allan Vaag (28300), Pernille Poulsen (28289)   +5 more
core   +1 more source

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

Cells, 2022
Background: Myeloid cells are critical determinants of the sustained inflammation in Crohn’s Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal domain protein inhibitors (
Ahmed M. I. Elfiky, Ishtu L. Hageman, Marte A. J. Becker, Jan Verhoeff, Andrew Y. F. Li Yim, Vincent W. Joustra, Lieven Mulders, Ivan Fung, Inmaculada Rioja, Rab K. Prinjha, Nicholas N. Smithers, Rebecca C. Furze, Palwinder K. Mander, Matthew J. Bell, Christianne J. Buskens, Geert R. D’Haens, Manon E. Wildenberg, Wouter J. de Jonge   +17 more
doaj   +1 more source

Horse carboxylesterases: Evidence for six CES1 and four families of CES genes on chromosome 3

, 2009
Carboxylesterases (CES) are responsible for the detoxification of a wide range of drugs and xenobiotics, and may contribute to cholesterol, fatty acid and lung surfactant metabolism.
A. Cox, Laura, Holmes, Roger, L. VandeBerg, John, Cox, Laura A, VandeBerg, John L, Holmes, Roger S   +5 more
core   +1 more source