Results 71 to 80 of about 6,102 (207)

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

Clinical and Translational Science, 2021
Trandolapril, an angiotensin‐converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect.
Xinwen Wang, Lucy Her, Jingcheng Xiao, Jian Shi, Audrey H. Wu, Barry E. Bleske, Hao‐Jie Zhu   +6 more
doaj   +1 more source

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

IMPACT OF ABCB1 AND CES1 GENETIC POLYMORPHISMS ON TROUGH STEADY-STATE DABIGATRAN CONCENTRATIONS IN PATIENTS AFTER ENDOPROSTHESIS OF KNIFE JOIN

Атеротромбоз, 2018
Oral anticoagulants are widely used to prevent thromboembolic events in patients following total knee arthroplasty [1]. The genetic characteristics of patients affect the efficacy and safety of anticoagulants [2].
D. A. Sychev, A. N. Levanov, T. V. Shelekhova, P. O. Bochkov, N. Р. Denisenko, K. A. Ryzhikova, K. В. Mirzaev, E. A. Grishina, M. A. Gavrilov   +8 more
doaj   +1 more source

The Pharmacokinetics of Enalapril in Relation toCES1Genotype in Healthy Danish Volunteers [PDF]

Basic & Clinical Pharmacology & Toxicology, 2017
AbstractThis study investigated the influence of variations in the carboxylesterase 1 gene (CES1)on the pharmacokinetics of enalapril. Forty‐three healthy, Danish, Caucasian volunteers representing different pre‐defined genotypes each received 10 mg of enalapril.
Stage, Claus, Jürgens, Gesche, Guski, Louise Schow, Thomsen, Ragnar, Bjerre, Ditte, Ferrero-Miliani, Laura, Lyauk, Yassine Kamal, Berg Rasmussen, Henrik, Dalhoff, Kim   +8 more
openaire   +3 more sources

Comprehensive maximum likelihood estimation of diffusion compartment models towards reliable mapping of brain microstructure [PDF]

, 2016
open4siDiffusion MRI is a key in-vivo non invasive imaging capability that can probe the microstructure of the brain. However,its limited resolution requires complex voxelwise generative models of the diffusion.
B Scherrer, B Scherrer, D Marquardt, K Svanberg, Panagiotaki, V Essen, Zhang   +6 more
core   +3 more sources

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 4, Page 291-299, June 2026.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection

Pharmaceutics, 2021
ProTide technology is a powerful tool for the design of nucleoside/nucleotide analog prodrugs. ProTide prodrug design improves cell permeability and enhances intracellular activation.
Jiapeng Li, Shuhan Liu, Jian Shi, Hao-Jie Zhu   +3 more
doaj   +1 more source

A dysregulation in CES1, APOE and other lipid metabolism-related genes is associated to cardiovascular risk factors linked to obesity [PDF]

, 2010
OBJECTIVE: The aim of the present study was to investigate the relationship between the differential expression of genes related to lipid metabolism in subcutaneous adipose tissue and metabolic syndrome features in lean and obese subjects with ...
Gonzalez-Muniesa, P. (Pedro), Marrades, M.P. (María Pilar), Martinez, J.A. (José Alfredo), Moreno-Aliaga, M. J. (María Jesús)   +3 more
core  

Detection of Diagnostic Antibodies in Immune‐Mediated Diseases: A Focus on Antigens and Technologies

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review explores autoantibody detection in immune‐mediated diseases, highlighting autoantigens including post‐translational modifications. We compared enzyme‐linked immunosorbent assay and indirect immunofluorescence with automated chemiluminescence platforms.
Silvia Bracci, Feliciana Real‐Fernandez, Federico Pratesi, Francesca Nuti, Paolo Rovero, Anna Maria Papini   +5 more
wiley   +1 more source

Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity

Italian Journal of Pediatrics
Background Carboxylesterase 1(CES1) is expressed mainly in the liver and adipose tissue and is highly hypothesized to play an essential role in metabolism.
Huanyu Wang, Shimin Wu, Ying Weng, Xi Yang, Ling Hou, Yan Liang, Wei Wu, Yanqin Ying, Feng Ye, Xiaoping Luo   +9 more
doaj   +1 more source