Results 71 to 80 of about 3,685 (179)

Hypercholesterolemia and the role of lipid metabolism gene CES1 in immune infiltration promote central nervous system relapse in acute myeloid leukemia

Frontiers in Immunology
BackgroundAlterations in multiple lipid metabolism pathways are associated with cancer progression. However, the relationship between lipid metabolism and central nervous system (CNS) relapse in acute myeloid leukemia (AML) remains unclear.MethodsWe ...
Wanwan Bao, Wanwan Bao, Yansong Tu, Shan Zhang, Shan Zhang, Xiaoyan Jiang, Huijun Chen, Huaijun Tu, Jian Li   +8 more
doaj   +1 more source

Bovine carboxylesterases: Evidence for two CES1 and five families of CES genes on chromosome 18

, 2009
Predicted bovine carboxylesterase (CES) protein and gene sequences were derived from bovine (Bos taurus) genomic sequence data. Two bovine CES1 genes (CES1.1 and CES1.2) were located on chromosome 18 encoding amino acid sequences that were 81% identical.
Holmes, Roger, Cox, Laura A, VandeBerg, John L, VandeBerg, John L., Cox, Laura A., Holmes, Roger S   +5 more
core   +1 more source

Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRaf V600E /Pten −/− mice

Cancer & Metabolism
Background Melanoma is a highly aggressive skin cancer with a poor prognosis. The endocannabinoids 2-arachidonoylgylcerol (2-AG) and anandamide have been linked to melanoma progression, though their roles remain unclear.
Veronika Morozova, Daniele Pellegata, Roch-Philippe Charles, Jürg Gertsch   +3 more
doaj   +1 more source

GENETICS OF CLOPIDOGREL RESISTANCE: RECENT DATA

Российский кардиологический журнал, 2015
Antiplatelet therapy is one of the most importance in therapy of patients with injured coronary, cerebral and peripheral arteries. The standard of acute coronary syndrome patients treatment is double antiplatelet therapy: acetylsalicylic acid with ...
K. B. Mirzaev, D. A. Sychev, D. A. Andreev   +2 more
doaj   +1 more source

Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach

Frontiers in Pharmacology, 2020
Vicagrel, a novel acetate derivative of clopidogrel, exhibits a favorable safety profile and excellent antiplatelet activity. Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes Cytochrome P450 2C19 (CYP2C19 ...
Shuaibing Liu, Ziteng Wang, Xin Tian, Weimin Cai   +3 more
doaj   +1 more source

Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells [PDF]

Murata M., Okada K., Takahashi M., et al. Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells. Toxicology Letters 401, 158 (2024); https://doi.org/10.1016/j.toxlet.2024.10.003.Caco-2 cells, a human ...
Okada, Kentaro, Mizuguchi, Hiroyuki, Murata, Michika, Ueyama-Toba, Yukiko, Takahashi, Masaki, Ito, Sumito   +5 more
core   +1 more source

APPLICATIONS OF PHARMACOGENETIC TESTING FOR PERSONALIZATION OF THERAPY WITH ORAL ANTICOAGULANTS IN RUSSIA

Рациональная фармакотерапия в кардиологии, 2015
The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic ...
D. A. Sychev, R. E. Kazakov, V. A. Otdelenov, A. B. Prokofiev   +3 more
doaj   +1 more source

Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions

Chemical Communications
Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. To address this, fluorogenic chemical tools that can monitor CES1 activity in live cells were developed.
Carolyn J. Karns, Taylor P. Spidle, Emmanuel Adusah, Mingze Gao, Jennifer E. Nehls, Michael W. Beck   +5 more
openaire   +3 more sources

The role of pharmacogenetics in personalizing anticoagulant therapy: data from the Astrakhan region

Фармация и фармакология (Пятигорск)
The metabolic characteristics of anticoagulants largely depend on the patient’s genetic profile, determining the variability of pharmacological response to drugs and the risk of adverse reactions.
A. N. Romanova, B. I. Kantemirova, O. V. Komarova, N. V. Timofeeva   +3 more
doaj   +1 more source

Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

Molecules, 2008
Mammalian carboxylesterases (CESs) comprise a multigene family whose geneproducts play important roles in biotransformation of ester- or amide-type prodrugs. Theyare members of an α,β-hydrolase-fold family and are found in various mammals.
Masakiyo Hosokawa
doaj   +1 more source