Results 71 to 80 of about 2,904 (163)
Рациональная фармакотерапия в кардиологии, 2015 The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic ...
D. A. Sychev +3 more
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Large mammal recovery in the wake of human population decline
Journal of Applied Ecology, Volume 63, Issue 5, May 2026.Human depopulation, particularly in rural areas, has contributed to the recovery of some large mammal populations. While recovery is generally good news for conservation, it can also lead to human‐wildlife conflict. We present several avenues to maximize coexistence in the face of further rural depopulation in other places. Read the free Plain Language
Alex J. Jensen +4 more
wiley +1 more source
Molecules, 2020 Gemcitabine (dFdC) demonstrates significant effectiveness against solid tumors in vitro and in vivo; however, its clinical application is limited because it tends to easily undergo deamination metabolism.
Yilin Sun, Jiankun Wang, Kun Hao
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Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Clopidogrel is an antiplatelet agent widely utilized in cardiology. It is a prodrug activated in the liver by the cytochrome P450 isoform CYP2C19. Variability in the CYPC2C19 gene influences the activation and efficacy of clopidogrel. This is covered in guidelines from the Clinical Pharmacogenetics Implementation Consortium, the Dutch ...
Cinzia Dello Russo +5 more
wiley +1 more source
Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions
Chemical CommunicationsStudying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. To address this, fluorogenic chemical tools that can monitor CES1 activity in live cells were developed.
Carolyn J. Karns +5 more
openaire +3 more sources
Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners
International Journal of Applied Linguistics, Volume 36, Issue 2, Page 1807-1820, May 2026.ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley +1 more source
The role of pharmacogenetics in personalizing anticoagulant therapy: data from the Astrakhan region
Фармация и фармакология (Пятигорск)The metabolic characteristics of anticoagulants largely depend on the patient’s genetic profile, determining the variability of pharmacological response to drugs and the risk of adverse reactions.
A. N. Romanova +3 more
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Molecules, 2008 Mammalian carboxylesterases (CESs) comprise a multigene family whose geneproducts play important roles in biotransformation of ester- or amide-type prodrugs. Theyare members of an α,β-hydrolase-fold family and are found in various mammals.
Masakiyo Hosokawa
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Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
Scientific Reports, 2017 Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south
Fei-Yan Xiao +8 more
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Human carboxylesterases: a comprehensive review
Acta Pharmaceutica Sinica B, 2018 Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade.
Dandan Wang +5 more
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