Results 91 to 100 of about 6,102 (207)

Single‐Cell Profiling Reveals RAB13+ Endothelial Cells and Profibrotic Mesenchymal Cells in Aged Human Bone Marrow

Aging Cell, Volume 25, Issue 4, April 2026.
Integrated single‐cell, spatial transcriptomic, and immunofluorescence analyses reveal profound aging‐associated remodeling of the non‐immune human bone marrow niche. Aging is marked by endothelial dysfunction, emergence of RAB13+ arterial endothelial cells, and expansion of profibrotic THY1+ mesenchymal cells, identifying potential cellular targets ...
Itziar Cenzano, Miguel Cócera, Ana Rosa Lopez‐Perez, Lorea Campos‐Dopazo, Javier Ruiz, Ignacio Sancho, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Sarai Sarvide, Amaia Vilas‐Zornoza, Purificacion Ripalda‐Cemborain, Diego Alignani, Aitziber Lopez, Marta Miñana Barrios, Delia Quilez Agreda, Jin Ye, Robert Lehmann, Laura Sudupe, Marta Abengozar‐Muela, Álvaro Lopez‐Janeiro, Luis‐Esteban Tamariz‐Amador, Emma Muiños‐López, Borja Saez, Jesper Tegner, Isabel A. Calvo, David Gomez‐Cabrero, Felipe Prosper   +26 more
wiley   +1 more source

GENETICS OF CLOPIDOGREL RESISTANCE: RECENT DATA

Российский кардиологический журнал, 2015
Antiplatelet therapy is one of the most importance in therapy of patients with injured coronary, cerebral and peripheral arteries. The standard of acute coronary syndrome patients treatment is double antiplatelet therapy: acetylsalicylic acid with ...
K. B. Mirzaev, D. A. Sychev, D. A. Andreev   +2 more
doaj   +1 more source

Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin‐Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model

Veterinary Dermatology, Volume 37, Issue 2, Page 200-210, April 2026.
Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk   +9 more
wiley   +1 more source

Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects

Pharmaceutics
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the ...
Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu   +5 more
doaj   +1 more source

APPLICATIONS OF PHARMACOGENETIC TESTING FOR PERSONALIZATION OF THERAPY WITH ORAL ANTICOAGULANTS IN RUSSIA

Рациональная фармакотерапия в кардиологии, 2015
The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic ...
D. A. Sychev, R. E. Kazakov, V. A. Otdelenov, A. B. Prokofiev   +3 more
doaj   +1 more source

A Pharmacokinetic and Pharmacodynamic Evaluation of the Anti-Hepatocellular Carcinoma Compound 4-N-Carbobenzoxy-gemcitabine (Cbz-dFdC)

Molecules, 2020
Gemcitabine (dFdC) demonstrates significant effectiveness against solid tumors in vitro and in vivo; however, its clinical application is limited because it tends to easily undergo deamination metabolism.
Yilin Sun, Jiankun Wang, Kun Hao
doaj   +1 more source

Market Dynamics in Edgeworth Exchange [PDF]

Edgeworth exchange is the fundamental general equilibrium model, yet equilibrium predications and theories of price adjustment for this model remain untested.
Steven Gjerstad
core  

Irinotecan pathway genotype analysis to predict pharmacokinetics [PDF]

, 2003
PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan ...
Baker, S.D. (Sharyn), Karlsson, M.O., Marsh, S. (Steven), Mathijssen, A.H.J. (Ron), McLeod, H.L. (Howard), Sparreboom, A. (Alex), Verweij, J. (Jaap), Xie, R. (Rujia)   +7 more
core  

Genetic determinants of the pharmacokinetic variability of rifampin in Malawian adults with pulmonary tuberculosis [PDF]

, 2017
D.J.S. was supported by a Wellcome Trust Clinical PhD Fellowship (086757/Z/08/A to D.J.S.). A.D.M. was supported by a National Institute for Health Research Integrated Clinical Academic Training Fellowship and a Wellcome Trust Clinical PhD Fellowship ...
Allain, Theresa J., Banda, Gertrude, Davies, Geraint R., Egan, Deirdre, Khoo, Saye H., McCallum, Andrew D., Mwandumba, Henry C., Owen, Andrew, Schipani, Alessandro, Sloan, Derek J., Ward, Steve A., Waterhouse, David   +11 more
core   +4 more sources

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source