Results 91 to 100 of about 3,685 (179)

Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1

, 2017
Carboxylesterase 1 (CES1) is implicated in the metabolism of several commonly used drugs and other xenobiotics. The gene encoding this enzyme, CES1, is duplicated in some individuals. The original gene copy is called CES1A1.
Ditte Bjerre, Bjerre, Ditte, Henrik B. Rasmussen, Rasmussen, Henrik Berg   +3 more
core   +1 more source

Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics

Clinical and Translational Science
Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers great potential ...
Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell   +9 more
doaj   +1 more source

Identification of New Fluorescein-Based Chemical Tools for Studying Human Carboxylesterase 1 (CES1)

This thesis focuses on the significance of subcellular location-specific activity of hydrolases, exploring their implications for drug-drug interactions (DDIs) and sequence polymorphisms in drug metabolism.
Adusah, Emmanuel
core  

Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1)

, 2015
1. Fructus psoraleae (FP) is the dried ripe seeds of Psoralea corylifolia L. (Fabaceae) widely used in Asia, and has been reported to exert important biochemical and pharmacological activities. The adverse effects of FP remain unclear.
Hui-Ming Hua (534567), Rui-Xue Ran (825328), Pei-Pei Dong (825325), Dong-Xue Sun (825323), Ran, Rui-Xue, Sun, Dong-Xue, Zhenying Zhao (825329), Fang, Zhong-Ze, Yun-Feng Cao (825326), Fu, Zhi-Wei, Zhang, Yan-Yan, Dong, Pei-Pei, Hua, Hui-Ming, Wu, Xue, Guang-Bo Ge (825324), Zhi-Wei Fu (825327), Yan-Yan Zhang (468715), Xue Wu (317735), Zhong-Ze Fang (825330), Cao, Yun-Feng, Ge, Guang-Bo, Zhao, Zhenying   +21 more
core   +1 more source

The interplay between CES1 gene polymorphisms and environmental exposures in chemotherapy toxicity in breast cancer: CES1 variants and environment in chemo toxicity

Breast cancer remains one of the most prevalent malignancies worldwide, with chemotherapy serving as a cornerstone of treatment despite its substantial toxicity risks.
Aygunes Jafari, Duygu, Sezgin, Canfeza, Kosova, Buket   +2 more
core   +1 more source

Adipocyte abundances of CES1, CRYAB, ENO1 and GANAB are modified in-vitro by glucose restriction and are associated with cellular remodelling during weight regain

, 2019
Long-term weight loss maintenance is a problem of overweight and obesity. Changes of gene expression during weight loss (WL) by calorie restriction (CR) are linked to the risk of weight regain (WR).
Marleen A. van Baak (7460957), Edwin C. M. Mariman (7460948), Mariman, Edwin C. M., van Baak, Marleen A., Renes, Johan W., Roel G. Vink (5577332), Johan W. Renes (6649685), Susan L. M. Coort (6649682), Roumans, Nadia J. T., Bouwman, Freek G., Qi Qiao (623629), Vink, Roel G., Freek G. Bouwman (230180), Nadia J. T. Roumans (5577329), Qiao, Qi; id_orcid, Coort, Susan L. M.; id_orcid   +15 more
core   +1 more source

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Frontiers in Pharmacology
PurposeThe impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran esters in healthy Chinese subjects employed a population pharmacokinetic (PopPK) approach.MethodsIn total, 1,
Zhuan Yang, Zhuan Yang, Wen Rui Tan, Qin Li, Ying Wang, Shijing Liu, Lu Chen, Yan Zhou, Chen Zeng, Yan Zeng, Yun Xiong, Qian Zhang, Na Li, Peng Du, Lin Liu, Jiyu Chen, Jiyu Chen, Yan He, Yan He   +18 more
openaire   +3 more sources

Methylphenidate side effect profile is influenced by genetic variation in the attention-deficit/hyperactivity disorder-associated CES1 gene

, 2013
Objective: A naturalistic, prospective study of the influence of genetic variation on dose prescribed, clinical response, and side effects related to stimulant medication in 77 children with attention-deficit/hyperactivity disorder (ADHD) was undertaken.
Lambert, David, Johnson, Katherine A., Kirley, Aiveen, Hawi, Ziarih, Gill, Michae, McNicholas, Fiona, Fitzgerald, Michael, Barry, Edwina, Bellgrove, Mark A.   +8 more
core   +1 more source

CES1 Gene [PDF]

, 2020
openaire   +1 more source

CES1 wt Allele [PDF]

, 2020
openaire   +1 more source