Results 91 to 100 of about 3,332 (192)
, 2013 Objective: A naturalistic, prospective study of the influence of genetic variation on dose prescribed, clinical response, and side effects related to stimulant medication in 77 children with attention-deficit/hyperactivity disorder (ADHD) was undertaken.
Lambert, David +8 more
core +1 more source
GENETICS OF CLOPIDOGREL RESISTANCE: RECENT DATA
Российский кардиологический журнал, 2015 Antiplatelet therapy is one of the most importance in therapy of patients with injured coronary, cerebral and peripheral arteries. The standard of acute coronary syndrome patients treatment is double antiplatelet therapy: acetylsalicylic acid with ...
K. B. Mirzaev +2 more
doaj +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Clopidogrel is an antiplatelet agent widely utilized in cardiology. It is a prodrug activated in the liver by the cytochrome P450 isoform CYP2C19. Variability in the CYPC2C19 gene influences the activation and efficacy of clopidogrel. This is covered in guidelines from the Clinical Pharmacogenetics Implementation Consortium, the Dutch ...
Cinzia Dello Russo +5 more
wiley +1 more source
Рациональная фармакотерапия в кардиологии, 2015 The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic ...
D. A. Sychev +3 more
doaj +1 more source
Molecules, 2020 Gemcitabine (dFdC) demonstrates significant effectiveness against solid tumors in vitro and in vivo; however, its clinical application is limited because it tends to easily undergo deamination metabolism.
Yilin Sun, Jiankun Wang, Kun Hao
doaj +1 more source
Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners
International Journal of Applied Linguistics, Volume 36, Issue 2, Page 1807-1820, May 2026.ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley +1 more source
, 2013 The statistical model is: ln(response variable) = age+sex+BMI+CES1 mRNA level. The regression coefficient expresses the change in the response variable associated with a doubling of CES1 mRNA level from its average. CES1: carboxylesterase 1 gene; HOMA-IR:
Peter Riis Hansen (283251) +5 more
core +1 more source
Bovine carboxylesterases: Evidence for two CES1 and five families of CES genes on chromosome 18
, 2009 Predicted bovine carboxylesterase (CES) protein and gene sequences were derived from bovine (Bos taurus) genomic sequence data. Two bovine CES1 genes (CES1.1 and CES1.2) were located on chromosome 18 encoding amino acid sequences that were 81% identical.
Holmes, Roger +5 more
core +1 more source
Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe +6 more
wiley +1 more source
Advanced Intelligent Systems, Volume 8, Issue 4, April 2026.gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley +1 more source