Results 111 to 120 of about 3,332 (192)

Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants [PDF]

, 2016
The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain interindividual variability and further increase the safety of MPH.
Bergmann, T K; id_orcid, Lyauk, Y K, Stage, C, Ferrero-Milliani, L, Bergmann, T K, Jürgens, G, Dalhoff, Kim Peder, Ferrero, Laura, Jürgens, G., Rasmussen, H.B., Rasmussen, H B, Dalhoff, K P, Thomsen, R, Bjerre, D   +13 more
core   +1 more source

Impaired chylomicron clearance in Ces1/Es-x^−/− mice.

, 2013
(A) Fat tolerance test in 12-h fasted mice. Mice were gavaged with 150 µl olive oil. Blood samples were collected at the indicated times, plasma was prepared and TG concentrations were measured by gas chromatography. N = 4–6 mice/group.
Ariel D. Quiroga (300200), Richard Lehner (300203), Jihong Lian (300202)   +2 more
core   +1 more source

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Frontiers in Pharmacology
PurposeThe impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran esters in healthy Chinese subjects employed a population pharmacokinetic (PopPK) approach.MethodsIn total, 1,
Zhuan Yang, Zhuan Yang, Wen Rui Tan, Qin Li, Ying Wang, Shijing Liu, Lu Chen, Yan Zhou, Chen Zeng, Yan Zeng, Yun Xiong, Qian Zhang, Na Li, Peng Du, Lin Liu, Jiyu Chen, Jiyu Chen, Yan He, Yan He   +18 more
openaire   +3 more sources

Data for Fluorogenic Chemical Tools to Shed Light on CES1-Mediated Adverse Drug Interactions

Data for Fluorogenic Chemical Tools to Shed Light on CES1-Mediated Adverse Drug ...
Taylor P. Spidle, Emmanuel Adusah, Carolyn J. Karns, Michael W. Beck, Mingze Gao, Jennifer E. Nehls   +5 more
core   +1 more source

Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics

Clinical and Translational Science
Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers great potential ...
Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell   +9 more
doaj   +1 more source

Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells [PDF]

Murata M., Okada K., Takahashi M., et al. Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells. Toxicology Letters 401, 158 (2024); https://doi.org/10.1016/j.toxlet.2024.10.003.Caco-2 cells, a human ...
Okada, Kentaro, Mizuguchi, Hiroyuki, Murata, Michika, Ueyama-Toba, Yukiko, Takahashi, Masaki, Ito, Sumito   +5 more
core   +1 more source

Heritability of CES1 and CES1P1 mRNA expression levels in adipose tissue.

, 2013
The heritability was determined as: h2 = 2[rMZ−rDZ]. In this equation h2 is the heritability coefficient; rMZ and rDZ are intra-class correlations within monozygotic (MZ) and dizygotic (DZ) twins, respectively. Due to missing biopsies or technical issues
Peter Riis Hansen (283251), Henrik Berg Rasmussen (384275), Martin Friedrichsen (113408), Jørgen Wojtaszewski (384274), Allan Vaag (28300), Pernille Poulsen (28289)   +5 more
core   +1 more source

CES1 Deficiency is Associated With Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension

American Journal of Respiratory and Critical Care Medicine
Abstract Background Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary microvascular loss and obliterative remodeling driven by endothelial dysfunction. Low penetrance of only BMPR2 mutations causing metabolic shifts in pulmonary microvascular endothelial ...
Stuti Agarwal, Lyong Heo, Ananya Chakraborty, Ankita Mitra, Lichao Liu, Natasha Auer, Gowri Swaminathan, Flora Huang, Prakash Chelladurai, Eleana Guardado, Juan Matos, Anuradha Bankar, Crystal Le, James West, Karthik Suresh, Ramesh V Nair, Marlene Rabinovitch, Bruce D. Hammock, Christophe Morisseau, Joseph C Wu, Zoltan Arany, Mark R. Nicolls, Vinicio A. de Jesus Perez   +22 more
openaire   +1 more source

Development of a Chemical Biology Approach to Uncover the Influence of Sequence Variations on CES1 Activity in Live Cells

, 2023
Drug metabolism is the biochemical process of modifying drugs to detoxify and remove them through enzymatic transformations. These biotransformation’s occur primarily in the liver and are critical to understanding how pharmaceutical compounds are ...
Knebel, Samuel James
core  

CES1 Releases Oxylipins from Oxidized Triacylglycerol (oxTAG) and Regulates Macrophage oxTAG/TAG Accumulation and PGE₂/IL-1β Production

Triacylglycerols (TAGs) are storage forms of fat, primarily found in cytoplasmic lipid droplets in cells. TAGs are broken down to their component free fatty acids by lipolytic enzymes when fuel reserves are required.
Abdolsamad Borazjani (1339980), Maggie E. Phillips (16426704), Oluwabori Adekanye (13794851), Matthew K. Ross (1339989), J. Allen Crow (1339986)   +4 more
core   +2 more sources