Results 101 to 110 of about 3,685 (179)

CES1 Releases Oxylipins from Oxidized Triacylglycerol (oxTAG) and Regulates Macrophage oxTAG/TAG Accumulation and PGE₂/IL-1β Production

Triacylglycerols (TAGs) are storage forms of fat, primarily found in cytoplasmic lipid droplets in cells. TAGs are broken down to their component free fatty acids by lipolytic enzymes when fuel reserves are required.
Abdolsamad Borazjani (1339980), Maggie E. Phillips (16426704), Oluwabori Adekanye (13794851), Matthew K. Ross (1339989), J. Allen Crow (1339986)   +4 more
core   +2 more sources

Role of CES1 and ABCB1 Genetic Polymorphisms on Functional Response to Dabigatran in Patients with Atrial Fibrillation

Journal of Clinical Medicine
Background: Dabigatran etexilate is a pro-drug hydrolyzed into dabigatran by carboxylesterases (CES) and is a substrate of the P-Glycoprotein encoded by the adenosine-triphosphate-binding cassette sub-family B member (ABCB)1 genes. We evaluated the functional response to dabigatran according to different CES1 and ABCB1 single-nucleotide polymorphisms ...
Luca Cumitini, Giulia Renda, Mara Giordano, Roberta Rolla, Tarek Shail, Sara Sacchetti, Lorena Iezzi, Luca Giacomini, Valentina Zanotti, Raffaella Auciello, Ilaria Angilletta, Melissa Foglietta, Mirco Zucchelli, Ivana Antonucci, Liborio Stuppia, Sabina Gallina, Umberto Dianzani, Giuseppe Patti   +17 more
openaire   +4 more sources

Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems

, 2019
Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally ...
Xiangge Tian, Jingnan Cui (1964074), Kun Li, Jie Hou (130874), Lele Ding, Zhenhao Tian, Yunqing Song (6616838), Jie Hou, Lele Ding (6616835), Guangbo Ge (5249102), Yunqing Song, Tongyi Dou (6011057), Xiangge Tian (4600132), Tongyi Dou, Lei Feng, Jingnan Cui, Guangbo Ge, Lei Feng (122689), Zhenhao Tian (6616832), Kun Li (277035)   +19 more
core   +1 more source

Carboxylesterase 1 (CES1; hCE1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A [PDF]

, 2017
The homologous Saccharomyces cerevisiae genes CES1 and CES4 act as high copy suppressors of temperature-sensitive mutations of Ceg1p, the yeast mRNA capping enzyme. Neither CES1 nor CES4 is essential for cell growth. We find that a double deletion mutant
Schwer, Beate, Linder, Patrick, Shuman, Stewart   +2 more
core  

The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty

, 2018
Dmitriy Alekseevich Sychev,1 Alexander Nikolaevich Levanov,2 Tatiana Vladimirovna Shelekhova,2 Pavel Olegovich Bochkov,3 Natalia Pavlovna Denisenko,4 Kristina Anatolyevna Ryzhikova,4 Karin Badavievich Mirzaev,3 Elena Anatolyevna Grishina,4 Mikhail ...
Ramenskaya GV, Ryzhikova KA, Sychev DA, Levanov AN, Shelekhova TV, Grishina EA, Gavrilov MA, Mirzaev KB, Denisenko NP, Kozlov AV, Bogoslovsky T, Bochkov PO   +11 more
core  

Metastatik meme kanserli hastalarda CES1 gen polimorfizmlerinin görülme sıklıkları ve capecitabine kullananlarda ilaç yanıtına etkilerinin retrospektif olarak değerlendirilmesi [PDF]

, 2008
Meme kanseri dünyada sık görülen ve kadın ölümlerinden en fazla sorumlu olan multifaktoriyel bir hastalıktır. Nedenleri arasında üremeyle ilgili etkenler, hormonal etkenler, genetik etkenler ve sosyo-ekonomik durum gibi faktörler yer almaktadır.
Aygüneş, Duygu Döndü
core  

Pharmacogenetics of Carboxylesterase 1 [PDF]

, 2017
Carboxylesterases (CESs) catalyze the hydrolysis of a variety of ester- and amide containing compounds to their respective free acids. The main CES isozymes involved in drug metabolism are carboxylesterases 1 and 2 (CES1 and CES2). CES1 contributes to an
Tarkiainen, Katriina
core  

Cancer-associated fibroblasts drive immune resistance in MSS colorectal cancer via the FAIM2-CES1-ER stress pathway. [PDF]

Mol Cell Biochem
Tang R, Wan H, Zhong M, Yan K, Xu B, Xiong J.   +5 more
europepmc   +1 more source

PBPK Modeling of CES1-Activated Prodrugs Across Different Age Groups: Simultaneous Prodrug-Metabolite Prediction for Oseltamivir, Enalapril, and Cilazapril. [PDF]

Pharmaceutics
Li P, Yang Y, Jiang L, Wang J.
europepmc   +1 more source