Results 101 to 110 of about 3,332 (192)

Single‐Cell Profiling Reveals RAB13+ Endothelial Cells and Profibrotic Mesenchymal Cells in Aged Human Bone Marrow

Aging Cell, Volume 25, Issue 4, April 2026.
Integrated single‐cell, spatial transcriptomic, and immunofluorescence analyses reveal profound aging‐associated remodeling of the non‐immune human bone marrow niche. Aging is marked by endothelial dysfunction, emergence of RAB13+ arterial endothelial cells, and expansion of profibrotic THY1+ mesenchymal cells, identifying potential cellular targets ...
Itziar Cenzano, Miguel Cócera, Ana Rosa Lopez‐Perez, Lorea Campos‐Dopazo, Javier Ruiz, Ignacio Sancho, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Sarai Sarvide, Amaia Vilas‐Zornoza, Purificacion Ripalda‐Cemborain, Diego Alignani, Aitziber Lopez, Marta Miñana Barrios, Delia Quilez Agreda, Jin Ye, Robert Lehmann, Laura Sudupe, Marta Abengozar‐Muela, Álvaro Lopez‐Janeiro, Luis‐Esteban Tamariz‐Amador, Emma Muiños‐López, Borja Saez, Jesper Tegner, Isabel A. Calvo, David Gomez‐Cabrero, Felipe Prosper   +26 more
wiley   +1 more source

Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

Molecules, 2008
Mammalian carboxylesterases (CESs) comprise a multigene family whose geneproducts play important roles in biotransformation of ester- or amide-type prodrugs. Theyare members of an α,β-hydrolase-fold family and are found in various mammals.
Masakiyo Hosokawa
doaj   +1 more source

The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty

, 2018
Dmitriy Alekseevich Sychev,1 Alexander Nikolaevich Levanov,2 Tatiana Vladimirovna Shelekhova,2 Pavel Olegovich Bochkov,3 Natalia Pavlovna Denisenko,4 Kristina Anatolyevna Ryzhikova,4 Karin Badavievich Mirzaev,3 Elena Anatolyevna Grishina,4 Mikhail ...
Ramenskaya GV, Ryzhikova KA, Sychev DA, Levanov AN, Shelekhova TV, Grishina EA, Gavrilov MA, Mirzaev KB, Denisenko NP, Kozlov AV, Bogoslovsky T, Bochkov PO   +11 more
core  

Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions

Chemical Communications
Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. To address this, fluorogenic chemical tools that can monitor CES1 activity in live cells were developed.
Carolyn J. Karns, Taylor P. Spidle, Emmanuel Adusah, Mingze Gao, Jennifer E. Nehls, Michael W. Beck   +5 more
openaire   +3 more sources

Efficient in vitro refolding and functional characterization of recombinant human liver carboxylesterase (CES1) expressed in E. coli

, 2015
Human liver carboxylesterase 1 (CES1) plays a critical role in the hydrolysis of various ester- and amide-containing molecules, including active metabolites, drugs and prodrugs.
Boonyuen, Usa, Imwong, Mallika, Junkree, Suwapat, Day, Nichloas P.J., Promnares, Kamoltip   +4 more
core   +1 more source

Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients

Scientific Reports, 2017
Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south
Fei-Yan Xiao, Jian-Quan Luo, Min Liu, Bi-Lian Chen, Shan Cao, Zhao-Qian Liu, Hong-Hao Zhou, Gan Zhou, Wei Zhang   +8 more
doaj   +1 more source

Datasheet1_Associations between CES1 variants and dosing and adverse effects in children taking methylphenidate.docx

, 2023
BackgroundMethylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders to the medication.
Allise Taran (14442933), Christine Henzler (3580871), Ron Regal (14442936), Jacob T. Brown (14442927), Tyler Stevens (194848), Catherine A. McCarty (6830066), Jonathan Badalamenti (6313937), Nancy Beery (14442930)   +7 more
core   +1 more source

Association of CES1 gene copy number with measures of adiposity and metabolic regulation.

, 2013
The statistical model is: ln(response variable) = age+sex+BMI+CES1 copy number.1Group average with SD in brackets. BMI: body-mass index; CES1: carboxylesterase 1 gene; CES1P1: carboxylesterase 1 pseudogene 1; HOMA-IR: homeostasis assessment model-insulin
Peter Riis Hansen (283251), Henrik Berg Rasmussen (384275), Martin Friedrichsen (113408), Jørgen Wojtaszewski (384274), Allan Vaag (28300), Pernille Poulsen (28289)   +5 more
core   +1 more source

Human carboxylesterases: a comprehensive review

Acta Pharmaceutica Sinica B, 2018
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade.
Dandan Wang, Liwei Zou, Qiang Jin, Jie Hou, Guangbo Ge, Ling Yang   +5 more
doaj   +1 more source

Uloga polimorfizama gena CES1 u kliničkoj medicini

, 2023
Dabigatran je aktivni oblik prolijeka dabigatraneteksilata koji pripada skupini direktnih oralnih antikoagulansa (DOAK) te djeluje kao izravni oralni inhibitor trombina. Ranija istraživanja su pokazala značajnu interindividualnu varijabilnost u plazmatskim koncentracijama dabigatrana zbog čega je u kasnijim studijama istraživan utjecaj genetičkih i ...
openaire   +1 more source