Results 81 to 90 of about 3,685 (179)
, 2020 The genes that influence prostate cancer progression remain largely unknown. Since the carboxylesterase gene family plays a crucial role in xenobiotic metabolism and lipid/cholesterol homeostasis, we hypothesize that genetic variants in carboxylesterase ...
Wei-Chung Cheng +8 more
core +1 more source
Data for Fluorogenic Chemical Tools to Shed Light on CES1-Mediated Adverse Drug Interactions
Data for Fluorogenic Chemical Tools to Shed Light on CES1-Mediated Adverse Drug ...
Taylor P. Spidle +5 more
core +1 more source
Carboxylesterase 1 genes:systematic review and evaluation of existing genotyping procedures [PDF]
, 2018 The carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 (CES1P1), has been implicated in gene exchange with CES1 and in the formation of hybrid genes ...
Henrik Berg Rasmussen +3 more
core +1 more source
Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
Scientific Reports, 2017 Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south
Fei-Yan Xiao +8 more
doaj +1 more source
Uloga polimorfizama gena CES1 u kliničkoj medicini
, 2023 Dabigatran je aktivni oblik prolijeka dabigatraneteksilata koji pripada skupini direktnih oralnih antikoagulansa (DOAK) te djeluje kao izravni oralni inhibitor trombina. Ranija istraživanja su pokazala značajnu interindividualnu varijabilnost u plazmatskim koncentracijama dabigatrana zbog čega je u kasnijim studijama istraživan utjecaj genetičkih i ...
openaire +1 more source
Frontiers in GeneticsIntroductionGenetic variation in genes coding for enzymes metabolising antihypertensive drugs, may affect the efficacy of angiotensin converting enzyme (ACE) inhibitors such as enalapril, potentially leading to resistant hypertension (RHTN).
Jonathan N. Katsukunya +17 more
doaj +1 more source
SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating the lysosomal degradation of CES1 (carboxylesterase 1)
Lee, Wonseok +9 more
core +1 more source
Human carboxylesterases: a comprehensive review
Acta Pharmaceutica Sinica B, 2018 Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade.
Dandan Wang +5 more
doaj +1 more source
Correlation between CES1 mRNA expression level and selected variables.
, 2013 Correlation of CES1 mRNA level with body-mass index (BMI) (A, n = 204 twin subjects), homeostasis model assessment-insulin resistance (HOMA-IR) (B, n = 203 twin subjects), fasting plasma triglyceride levels (C, n = 205 twin subjects), and CES1P1 mRNA ...
Peter Riis Hansen (283251) +5 more
core +1 more source
American Journal of Respiratory and Critical Care MedicineAbstract Rationale Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary microvascular loss and obliterative remodeling driven by endothelial dysfunction. Low penetrance of only bone morphogenetic protein receptor 2 (BMPR2) mutations causing metabolic shifts ...
Stuti Agarwal +22 more
openaire +1 more source