Results 81 to 90 of about 6,102 (207)

Physiologically-Based Pharmacokinetic-Pharmacodynamics Model Characterizing CYP2C19 Polymorphisms to Predict Clopidogrel Pharmacokinetics and Its Anti-Platelet Aggregation Effect Following Oral Administration to Coronary Artery Disease Patients With or Without Diabetes

Frontiers in Pharmacology, 2020
Background and Objective: Clopidogrel (CLOP) is commonly used in coronary artery disease (CAD) patients with or without diabetes (DM), but these patients often suffer CLOP resistance, especially those with diabetes.
Ru-jun Xu, Wei-min Kong, Xiao-fei An, Jian-jun Zou, Jian-jun Zou, Li Liu, Xiao-dong Liu   +6 more
doaj   +1 more source

Large mammal recovery in the wake of human population decline

Journal of Applied Ecology, Volume 63, Issue 5, May 2026.
Human depopulation, particularly in rural areas, has contributed to the recovery of some large mammal populations. While recovery is generally good news for conservation, it can also lead to human‐wildlife conflict. We present several avenues to maximize coexistence in the face of further rural depopulation in other places. Read the free Plain Language
Alex J. Jensen, Benjamin R. Goldstein, Keita Fukasawa, Fabiola Iannarilli, Roland Kays   +4 more
wiley   +1 more source

Microfluidic generation of networked droplet collections and lipid membrane constructs [PDF]

, 2014
We report on microfluidic strategies to generate several multi-compartment membrane-based structures, including droplet interface bilayer networks and multi-compartment vesicles.
Ces, O, Elani, Y, Law, R
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CES technology and business cycle fluctuations [PDF]

, 2015
We contribute to an emerging literature that brings the constant elasticity of substitution (CES) specification of the production function into the analysis of business cycle fluctuations. Using US data, we estimate by Bayesian-Maximum-Likelihood methods
Acemoglu, Acemoglu, Anderson, Arrow, Barnett, Bentolila, Blanchard, Boldrin, Cantore, Cantore, Chari, Chirinko, Christiano, Colciago, Del Negro, Del Negro, Diamond, Fernald, Fernandez-Villaverde, Galí, Gertler, Geweke, Geweke, Gomme, Hansen, Iskrev, Jones, Justiniano, Kass, Kennedy, Klump, Klump, Klump, La Grandville, La Grandville, Levine, León-Ledesma, Marquetti, McAdam, Neiman, Piketty, Rowthorn, Ríos-Rull, Shao, Smets, Smets, Solow   +46 more
core   +2 more sources

Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners

International Journal of Applied Linguistics, Volume 36, Issue 2, Page 1807-1820, May 2026.
ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley   +1 more source

Specific heat of Ba$_{0.59}$K$_{0.41}$Fe$_{2}$As$_{2}$, and a new method for identifying the electron contribution: two electron bands with different energy gaps in the superconducting state

, 2015
We report measurements of the specific heat of Ba$_{0.59}$K$_{0.41}$Fe$_{2}$As$_{2}$, an Fe-pnictide superconductor with $T_c$ = 36.9 K, for which there are suggestions of an unusual electron pairing mechanism. We use a new method of analysis of the data
Birgeneau, R. J., Forrest, T. R., Phillips, N. E., Rotundu, C. R.   +3 more
core   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach

Frontiers in Pharmacology, 2020
Vicagrel, a novel acetate derivative of clopidogrel, exhibits a favorable safety profile and excellent antiplatelet activity. Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes Cytochrome P450 2C19 (CYP2C19 ...
Shuaibing Liu, Ziteng Wang, Xin Tian, Weimin Cai   +3 more
doaj   +1 more source

gnSPADE: Incorporating Gene Network Structures Enhances Reference‐Free Deconvolution in Spatial Transcriptomics

Advanced Intelligent Systems, Volume 8, Issue 4, April 2026.
gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley   +1 more source

Research Advances: January 2014 [PDF]

, 2014
The VA has a comprehensive research agenda to help the newest generation of Veterans -- those returning from operations Enduring Freedom, Iraqi Freedom, and New Dawn.

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