Results 81 to 90 of about 2,904 (163)

Uloga polimorfizama gena CES1 u kliničkoj medicini

, 2023
Dabigatran je aktivni oblik prolijeka dabigatraneteksilata koji pripada skupini direktnih oralnih antikoagulansa (DOAK) te djeluje kao izravni oralni inhibitor trombina. Ranija istraživanja su pokazala značajnu interindividualnu varijabilnost u plazmatskim koncentracijama dabigatrana zbog čega je u kasnijim studijama istraživan utjecaj genetičkih i ...
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CES1 deficiency is associated with metabolic reprograming and endothelial dysfunction in pulmonary arterial hypertension

American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary microvascular loss and obliterative remodeling driven by endothelial dysfunction. Low penetrance of only bone morphogenetic protein receptor 2 (BMPR2) mutations causing metabolic shifts ...
Stuti Agarwal, Lyong Heo, Ananya Chakraborty, Ankita Mitra, Lichao Liu, Natasha Auer, Gowri Swaminathan, Flora Huang, Prakash Chelladurai, Eleana Guardado, Juan Matos, Anuradha Bankar, Crystal Le, James West, Karthik Suresh, Ramesh V Nair, Marlene Rabinovitch, Bruce D. Hammock, Christophe Morisseau, Joseph C Wu, Zoltan Arany, Mark R. Nicolls, Vinicio A. de Jesus Perez   +22 more
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Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Frontiers in Pharmacology
PurposeThe impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran esters in healthy Chinese subjects employed a population pharmacokinetic (PopPK) approach.MethodsIn total, 1,
Zhuan Yang, Zhuan Yang, Wen Rui Tan, Qin Li, Ying Wang, Shijing Liu, Lu Chen, Yan Zhou, Chen Zeng, Yan Zeng, Yun Xiong, Qian Zhang, Na Li, Peng Du, Lin Liu, Jiyu Chen, Jiyu Chen, Yan He, Yan He   +18 more
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Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics

Clinical and Translational Science
Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers great potential ...
Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell   +9 more
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CES1 Gene [PDF]

, 2020
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CES1 wt Allele [PDF]

, 2020
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Carboxylesterase 1 (CES1; hCE1) [PDF]

Science-Business eXchange, 2014
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The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty [Corrigendum]

Pharmacogenomics and Personalized Medicine, 2018
Sychev DA, Levanov AN, Shelekhova TV, Bochkov PO, Denisenko NP, Ryzhikova KA, Mirzaev KB, Grishina EA, Gavrilov MA, Ramenskaya GV, Kozlov AV, Bogoslovsky T. Pharmgenomics Pers Med. 2018;11:127-137. In this paper, the CC genotypes of CES1 (rs2244613)
Sychev DA, Levanov AN, Shelekhova TV, Bochkov PO, Denisenko NP, Ryzhikova KA, Mirzaev KB, Grishina EA, Gavrilov MA, Ramenskaya GV, Kozlov AV, Bogoslovsky T   +11 more
doaj  

Triazine Thiols Decrease Apolipoprotein B Secretion From Hepatocytes Through Inhibition of Human Carboxylesterase 1. [PDF]

Cell Mol Gastroenterol Hepatol
Blaszkiewicz J, Jiang YL, Liu JT, Martinez-Morant C, Dearth T, van Altena C, Lamprecht MP, Kappler C, Lee MH, Bethard JR, Ball LE, Duncan SA.   +11 more
europepmc   +1 more source

Variant-to-Biomarker Integration and Mechanistic Validation Identify CES1 as a Copy Number-Linked Predictor of Radiotherapy Response in Rectal Cancer. [PDF]

Hum Mutat
Yang X, Zheng M, Lu X, Li Y.
europepmc   +1 more source