Results 61 to 70 of about 3,685 (179)

Pharmacogenetic and Clinical Predictors of Clopidogrel Insufficiency in a Patient with Atherosclerosis Obliterans of the Lower Extremities: Clinical Case

Рациональная фармакотерапия в кардиологии, 2018
The considered clinical case of combination of multifocal atherosclerotic vascular lesion with type 2 diabetes mellitus and liver fibrosis demonstrates a combination of polyvalent risk factors  for resistance to antiplatelet therapy with clopidogrel. The
M. A. Andreyanova, K. B. Mirzaev, D. A. Sychev, K. A. Ryzhikova, A. V. Pokrovsky, A. F. Kharazov   +5 more
doaj   +1 more source

ACL is required for glucose-induced hepatic CES1 expression.

, 2014
(A) C57BL/6 mice were injected i.v. with adenovirus expressing GFP or ChREBP. After 5 days, hepatic mRNA levels were determined by qPCR (n = 7 mice per group).
Yang Xu (178421), Munaf Zalzala (640459), Yanqiao Zhang (109157), Jiesi Xu (640457), Liya Yin (640458), Yuanyuan Li (18671), Gang Cheng (108773)   +6 more
core   +1 more source

Bioactive lipid metabolism by carboxylesterase 1 (CES1) in macrophages (LB154)

The FASEB Journal, 2014
Human carboxylesterases (CES) have an emerging role in lipid metabolism. CES1 in macrophages is a hydrolase with broad endogenous substrate specificity, including cholesteryl ester, triacylglycerol, and 2‐arachidonoylglycerol (2‐AG), which may be relevant to cardiovascular disease and other pathologies related to lipid metabolism dysfunction.
Lee Mangum, Abdolsamad Borazjani, John Crow, Matthew Ross   +3 more
openaire   +1 more source

Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity

Italian Journal of Pediatrics
Background Carboxylesterase 1(CES1) is expressed mainly in the liver and adipose tissue and is highly hypothesized to play an essential role in metabolism.
Huanyu Wang, Shimin Wu, Ying Weng, Xi Yang, Ling Hou, Yan Liang, Wei Wu, Yanqin Ying, Feng Ye, Xiaoping Luo   +9 more
doaj   +1 more source

Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants [PDF]

, 2016
The aim of this study was to identify demographic and genetic factors that significantly affect methylphenidate (MPH) pharmacokinetics (PK), and may help explain interindividual variability and further increase the safety of MPH.
Bergmann, T K; id_orcid, Lyauk, Y K, Stage, C, Ferrero-Milliani, L, Bergmann, T K, Jürgens, G, Dalhoff, Kim Peder, Ferrero, Laura, Jürgens, G., Rasmussen, H.B., Rasmussen, H B, Dalhoff, K P, Thomsen, R, Bjerre, D   +13 more
core   +1 more source

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

Clinical and Translational Science, 2021
Trandolapril, an angiotensin‐converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect.
Xinwen Wang, Lucy Her, Jingcheng Xiao, Jian Shi, Audrey H. Wu, Barry E. Bleske, Hao‐Jie Zhu   +6 more
doaj   +1 more source

Development of a Chemical Biology Approach to Uncover the Influence of Sequence Variations on CES1 Activity in Live Cells [PDF]

, 2023
Drug metabolism is the biochemical process of modifying drugs to detoxify and remove them through enzymatic transformations. These biotransformation’s occur primarily in the liver and are critical to understanding how pharmaceutical compounds are ...
Knebel, Samuel James
core  

Association of CES1 gene copy number with measures of adiposity and metabolic regulation.

, 2013
The statistical model is: ln(response variable) = age+sex+BMI+CES1 copy number.1Group average with SD in brackets. BMI: body-mass index; CES1: carboxylesterase 1 gene; CES1P1: carboxylesterase 1 pseudogene 1; HOMA-IR: homeostasis assessment model-insulin
Peter Riis Hansen (283251), Henrik Berg Rasmussen (384275), Martin Friedrichsen (113408), Jørgen Wojtaszewski (384274), Allan Vaag (28300), Pernille Poulsen (28289)   +5 more
core   +1 more source

Physiologically-Based Pharmacokinetic-Pharmacodynamics Model Characterizing CYP2C19 Polymorphisms to Predict Clopidogrel Pharmacokinetics and Its Anti-Platelet Aggregation Effect Following Oral Administration to Coronary Artery Disease Patients With or Without Diabetes

Frontiers in Pharmacology, 2020
Background and Objective: Clopidogrel (CLOP) is commonly used in coronary artery disease (CAD) patients with or without diabetes (DM), but these patients often suffer CLOP resistance, especially those with diabetes.
Ru-jun Xu, Wei-min Kong, Xiao-fei An, Jian-jun Zou, Jian-jun Zou, Li Liu, Xiao-dong Liu   +6 more
doaj   +1 more source

Heritability of CES1 and CES1P1 mRNA expression levels in adipose tissue.

, 2013
The heritability was determined as: h2 = 2[rMZ−rDZ]. In this equation h2 is the heritability coefficient; rMZ and rDZ are intra-class correlations within monozygotic (MZ) and dizygotic (DZ) twins, respectively. Due to missing biopsies or technical issues
Peter Riis Hansen (283251), Henrik Berg Rasmussen (384275), Martin Friedrichsen (113408), Jørgen Wojtaszewski (384274), Allan Vaag (28300), Pernille Poulsen (28289)   +5 more
core   +1 more source