Results 61 to 70 of about 6,102 (207)

Surge in Expression of Carboxylesterase 1 During the Post-neonatal Stage Enables a Rapid Gain of the Capacity to Activate the Anti-influenza Prodrug Oseltamivir [PDF]

, 2017
Background. Oseltamivir, a widely used anti-influenza drug, is hydrolytically activated by carboxylesterase 1 (CES1). The expression of this carboxylesterase is developmentally regulated.
Davies, Brian E., Prinssen, Eric P., Shi, Deshi, Yan, Bingfang, Yang, Dongfang   +4 more
core  

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

The impact ofCES1genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects [PDF]

British Journal of Clinical Pharmacology, 2017
AimsThis study investigated the influence ofCES1variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate.MethodsCES1genotype was obtained from 200 healthy Danish Caucasian volunteers.
Stage, Claus, Jürgens, Gesche, Guski, Louise Schow, Thomsen, Ragnar, Bjerre, Ditte, Ferrero-Miliani, Laura, Lyauk, Yassine Kamal, Berg Rasmussen, Henrik, Dalhoff, Kim   +8 more
openaire   +3 more sources

Pharmacogenetics of Carboxylesterase 1 [PDF]

, 2017
Carboxylesterases (CESs) catalyze the hydrolysis of a variety of ester- and amide containing compounds to their respective free acids. The main CES isozymes involved in drug metabolism are carboxylesterases 1 and 2 (CES1 and CES2). CES1 contributes to an
Tarkiainen, Katriina
core  

Comparison of the structure and activity of glycosylated and asglycosylated human carboxylesterase 1 [PDF]

, 2015
Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically
AC Hemmert, AJ McCoy, Andreas Hofmann, AR Aricescu, CD Fleming, CD Fleming, CL Morton, David J. Scott, DI Stuart, DL Kroetz, DL Kroetz, DL Ollis, EI Parkinson, F Gorrec, G Koshland DN, GN Murshudov, HM Greenblatt, HM Greenblatt, J Monod, J Newman, JA Crow, JE Nettleship, JE Nettleship, JL Vaughn, Joanne E. Nettleship, K Nishi, LA Needham, M Alam, M Husokawa, M Suzuki-Kurasaki, Martin A. Walsh, Michael H. Charlton, MJ Hatfield, Nahid Rahman, NS Berrow, P Emsley, PA Karplus, PJ Reeves, PM Potter, PM Potter, Raymond J. Owens, RM Wadkins, RM Wadkins, RS Holmes, S Bencharit, S Bencharit, S Bencharit, S Bencharit, S Bencharit, S Takahashi, SN Ho, T Satoh, T Satoh, TS Walter, U Boonyuen, Victoria Arena de Souza, VT Chang   +56 more
core   +2 more sources

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A [PDF]

, 2017
The homologous Saccharomyces cerevisiae genes CES1 and CES4 act as high copy suppressors of temperature-sensitive mutations of Ceg1p, the yeast mRNA capping enzyme. Neither CES1 nor CES4 is essential for cell growth. We find that a double deletion mutant
Linder, Patrick, Schwer, Beate, Shuman, Stewart   +2 more
core  

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake, Melissa P. Swan, Kari J. Ekenstedt   +2 more
wiley   +1 more source

Pharmacogenetic and Clinical Predictors of Clopidogrel Insufficiency in a Patient with Atherosclerosis Obliterans of the Lower Extremities: Clinical Case

Рациональная фармакотерапия в кардиологии, 2018
The considered clinical case of combination of multifocal atherosclerotic vascular lesion with type 2 diabetes mellitus and liver fibrosis demonstrates a combination of polyvalent risk factors  for resistance to antiplatelet therapy with clopidogrel. The
M. A. Andreyanova, K. B. Mirzaev, D. A. Sychev, K. A. Ryzhikova, A. V. Pokrovsky, A. F. Kharazov   +5 more
doaj   +1 more source