Carboxylesterase1/Esterase-x regulates chylomicron production in mice. [PDF]
PLoS ONE, 2012 Elevated postprandial plasma triacylglycerol (TG) concentrations are commonly associated with obesity and the risk of cardiovascular disease. Dietary fat contributes to this condition through the production of chylomicrons.
Ariel D Quiroga +2 more
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A prognostic index model for assessing the prognosis of ccRCC patients by using the mRNA expression profiles of AIF1L, SERPINC1 and CES1 [PDF]
Journal of Men's Health, 2022 Background: Kidney carcinoma is a major cause of carcinoma-related death, with the prognosis for advanced or metastatic renal cell carcinoma still very poor.
Song Zheng +20 more
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Molecular Therapy: Nucleic Acids, 2021 Unexplained recurrent pregnancy loss (URPL) is a significant reproductive health issue, affecting approximately 5% of pregnancies. Enhancer RNAs (eRNAs) have been reported to play important roles during embryo development and may be related to URPL.
Zhenyao Huang +9 more
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Hepatology Communications, 2020 Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions.
Yanyong Xu +6 more
doaj +1 more source
Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors. [PDF]
PLoS ONE, 2016 BACKGROUND:Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure ...
Karl Emil Nelveg-Kristensen +8 more
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Frontiers in Nutrition, 2022 BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia +10 more
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Comparative clinical and economic evaluation of pharmacogenetic testing application for dabigatran in patients with atrial fibrillation [PDF]
Терапевтический архив, 2019 Aim. To evaluate the clinical and economic feasibility of pharmacogenetic testing (PGT) for dabigataran etexilate administration in the treatment of atrial fibrillation (AF) without valve in comparison with tactics without pharmacogenetic testing ...
Sh P Abdullaev, K B Mirzaev, D A Sychev
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Cannabinoid Inhibition of Carboxylesterase 1 (CES1)
The FASEB Journal, 2019 The increasing use of cannabis for both medical indications and on a recreational basis poses a potential for drug interactions between cannabis or one or more of its constituents and conventional therapeutic agents. Although significant efforts have been made to assess the in vitro and
Yuli Qian, John S. Markowitz
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The Pharmacokinetics of Enalapril in Relation toCES1Genotype in Healthy Danish Volunteers [PDF]
Basic & Clinical Pharmacology & Toxicology, 2017 AbstractThis study investigated the influence of variations in the carboxylesterase 1 gene (CES1)on the pharmacokinetics of enalapril. Forty‐three healthy, Danish, Caucasian volunteers representing different pre‐defined genotypes each received 10 mg of enalapril.
Stage, Claus +8 more
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The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation [PDF]
BMC Cardiovascular Disorders, 2022 Aims: This study aimed to analyze associations between genetic variants and plasma concentrations along with clinical outcomes in dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods: We conducted a prospective study and enrolled NVAF patients treated with dabigatran in the real world.
Zhu Zhu +7 more
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