Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. [PDF]
PLoS ONE, 2014 Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke.
Jiesi Xu +6 more
doaj +1 more source
Scientific Reports, 2021 A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol.
Bing bing Chen +8 more
doaj +1 more source
Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function. [PDF]
PLoS ONE, 2013 CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes.
Martin Friedrichsen +5 more
doaj +1 more source
Carboxylesterase1/Esterase-x regulates chylomicron production in mice. [PDF]
PLoS ONE, 2012 Elevated postprandial plasma triacylglycerol (TG) concentrations are commonly associated with obesity and the risk of cardiovascular disease. Dietary fat contributes to this condition through the production of chylomicrons.
Ariel D Quiroga +2 more
doaj +1 more source
A prognostic index model for assessing the prognosis of ccRCC patients by using the mRNA expression profiles of AIF1L, SERPINC1 and CES1 [PDF]
Journal of Men's Health, 2022 Background: Kidney carcinoma is a major cause of carcinoma-related death, with the prognosis for advanced or metastatic renal cell carcinoma still very poor.
Song Zheng +20 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Unexplained recurrent pregnancy loss (URPL) is a significant reproductive health issue, affecting approximately 5% of pregnancies. Enhancer RNAs (eRNAs) have been reported to play important roles during embryo development and may be related to URPL.
Zhenyao Huang +9 more
doaj +1 more source
Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors. [PDF]
PLoS ONE, 2016 BACKGROUND:Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure ...
Karl Emil Nelveg-Kristensen +8 more
doaj +1 more source
Hepatology Communications, 2020 Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions.
Yanyong Xu +6 more
doaj +1 more source
Comparative clinical and economic evaluation of pharmacogenetic testing application for dabigatran in patients with atrial fibrillation [PDF]
Терапевтический архив, 2019 Aim. To evaluate the clinical and economic feasibility of pharmacogenetic testing (PGT) for dabigataran etexilate administration in the treatment of atrial fibrillation (AF) without valve in comparison with tactics without pharmacogenetic testing ...
Sh P Abdullaev, K B Mirzaev, D A Sychev
doaj +1 more source
Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle [PDF]
, 2018 peer-reviewedThe genetic mechanisms controlling residual feed intake (RFI) in beef cattle are still largely unknown. Here we performed whole transcriptome analyses to identify differentially expressed (DE) genes and their functional roles in liver ...
Fitzsimmons, Carolyn +6 more
core +3 more sources