Results 21 to 30 of about 3,332 (192)

Reappraisal of the Genetic Diversity and Pharmacogenetic Assessment of CES1

Pharmacogenomics, 2017
The CES1 gene encodes a hydrolase that metabolizes important drugs. Variants generated by exchange of segments with CES1P1 complicate genotyping of CES1. Using a highly specific procedure we examined DNA samples from 200 Caucasians and identified 46 single nucleotide variants (SNVs) in CES1 and 21 SNVs in CES1A2, a hybrid composed of CES1 and CES1P1 ...
Ferrero-Miliani, Laura, Bjerre, Ditte, Stage, Claus, Madsen, Majbritt Busk, Jürgens, Gesche, Dalhoff, Kim Peder, Rasmussen, Henrik Berg, Linnet, Kristian, Thomsen, Ragnar, Stefansson, Hreinn, Hankemeier, Thomas, Kaddurah-Daouk, Rima, Brunak, Søren, Taboureau, Olivier, Nzabonimpa, Grace Shema, Houmann, Tine, Jeppesen, Pia, Kaalund-Jørgensen, Kristine, Hansen, Peter Riis, Kristensen, Karl Emil, Pagsberg, Anne Katrine, Plessen, Kerstin Jessica, Hansen, Poul Erik; id_orcid 0000-0003-4751-9910, Werge, Thomas, Dyrborg, Jørgen, Lauritzen, Maj Britt, Hughes, Timothy, Lyauk, Yassine Kamal   +27 more
openaire   +5 more sources

Individualization of Treatments with Drugs Metabolized by CES1: Combining Genetics and Metabolomics

Pharmacogenomics, 2015
CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic compounds including several essential and commonly used drugs. The individual variation in the efficacy and tolerability of many drugs metabolized by CES1 is considerable. Hence, there is a large interest in individualizing the treatment with these drugs. The present
Rasmussen, H.B., Bjerre, D., Linnet, K., Juergens, G., Dalhoff, K., Stefansson, H., Hankemeier, T., Kaddurah-Daouk, R., Taboureau, O., Brunak, S., Houmann, T., Jeppesen, P., Pagsberg, A.K., Plessen, K., Dyrborg, J., Hansen, P.R., Hansen, P.E., Hughes, T., Werge, T.   +18 more
openaire   +5 more sources

The role of ABCB1 and CES1 genotypes on the efficacy and safety of dabigatran: a systematic review and meta-analysis [PDF]

Human Genomics
Introduction : Dabigatran is a direct oral anticoagulant associated with a high incidence of gastrointestinal bleeding, which presents a significant clinical concern.
Weam Aldiban, Nada G. Hamam, Nereen A. Almosilhy, Kholoud Elsamman, Mohamed Wagdy, Doaa Mashaly, Suhel F. Batarseh, Youssef El-Sherif, Basma Badrawy Khalefa, Zina Otmani   +9 more
doaj   +2 more sources

Genetic Analysis Reveals a Significant Contribution of CES1 to Prostate Cancer Progression in Taiwanese Men [PDF]

Cancers, 2020
The genes that influence prostate cancer progression remain largely unknown. Since the carboxylesterase gene family plays a crucial role in xenobiotic metabolism and lipid/cholesterol homeostasis, we hypothesize that genetic variants in carboxylesterase genes may influence clinical outcomes for prostate cancer patients. A total of 478 (36 genotyped and
Chien-Chih Ke, Lih-Chyang Chen, Chia-Cheng Yu, Wei-Chung Cheng, Chao-Yuan Huang, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao   +8 more
openaire   +3 more sources

Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr −/− mice [PDF]

Scientific Reports, 2017
AbstractAtherosclerotic cardiovascular disease is a leading cause of death in the western world. Increased plasma triglyceride and cholesterol levels are major risk factors for this disease. Carboxylesterase 1 (Ces1/Ces1g) has been shown to play a role in metabolic control.
Jiesi Xu, Yang Xu, Yanyong Xu, Liya Yin, Yanqiao Zhang   +4 more
openaire   +3 more sources

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects

Pharmacogenomics and Personalized Medicine, 2021
Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y, Yang C, Qi W, Pei Z, Xue W, Zhu H, Dong M, Guo Y, Cong D, Wang F   +9 more
doaj   +4 more sources

Hypercholesterolemia and the role of lipid metabolism gene CES1 in immune infiltration promote central nervous system relapse in acute myeloid leukemia [PDF]

Frontiers in Immunology
BackgroundAlterations in multiple lipid metabolism pathways are associated with cancer progression. However, the relationship between lipid metabolism and central nervous system (CNS) relapse in acute myeloid leukemia (AML) remains unclear.MethodsWe ...
Wanwan Bao, Wanwan Bao, Yansong Tu, Shan Zhang, Shan Zhang, Xiaoyan Jiang, Huijun Chen, Huaijun Tu, Jian Li   +8 more
doaj   +2 more sources

Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning ...
Zhijun Xie, Hang Lei, Pengcheng Zhang, Zhi Li, Wenfu Tang   +4 more
doaj   +2 more sources

Associations between CES1 variants and dosing and adverse effects in children taking methylphenidate

Frontiers in Pediatrics, 2023
BackgroundMethylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders to the medication.
Jacob T. Brown, Nancy Beery, Allise Taran, Tyler Stevens, Christine Henzler, Jonathan Badalamenti, Ron Regal, Catherine A. McCarty   +7 more
doaj   +3 more sources

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1

Clinical and Translational Medicine, 2021
Background Androgen deprivation therapy (ADT) is the main clinical treatment for patients with advanced prostate cancer (PCa). However, PCa eventually progresses to castration‐resistant prostate cancer (CRPC), largely because of androgen receptor ...
Xiong Yang, Junyi Hu, Haruhiko Sugimura   +2 more
exaly   +2 more sources