Results 1 to 10 of about 19,287 (163)
Advanced Drug Delivery Reviews, 2009 ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the subject of intense study since its discovery a decade ago. With high normal tissue expression in the brain endothelium, gastrointestinal tract, and placenta, ABCG2 is believed to be important in the protection from xenobiotics, regulating oral bioavailability ...
Susan Bates, Rob Robey, Michael Dean
exaly +3 more sources
p38 inhibition restores chemosensitivity of tumor cells by disrupting oligomerized breast cancer resistance protein membrane trafficking [PDF]
iScienceSummary: Breast cancer resistance protein (ABCG2) significantly contributes to decreased sensitivity of tumor cells to chemotherapy. While ABCG2 inhibitors exist, multidrug resistance remains unresolved due to limited specificity, toxicity, and ...
Yanhong Pan +10 more
doaj +2 more sources
Role of the ABCG2 transporter in the biodistribution of the food-borne uremic toxin p-cresyl sulfate [PDF]
Scientific ReportsThe ATP-binding cassette transporter G2 (ABCG2) is a membrane transporter that conditions pharmacokinetics, systemic exposure, and milk secretion of drugs, natural and food-derived compounds, including gut-derived metabolites.
Alicia Millán-García +7 more
doaj +2 more sources
Redox BiologyThe transporter protein ABC subfamily G member 2 (ABCG2) is implicated in epilepsy; however, its specific role remains unclear. In this study, we assessed changes in ABCG2 expression and its role in epilepsy both in vitro and in vivo.
Zhiping Li, , Yongmin Chen
exaly +3 more sources
Acta Pharmaceutica Sinica B, 2020 Overexpression of adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2) in cancer cells is known to cause multidrug resistance (MDR), which severely limits the clinical efficacy of chemotherapy.
Liwu Fu, Kenneth To
exaly +3 more sources
Clinical Cancer Research, 2004 Abstract Purpose: The ATP-binding cassette transporter ABCG2 (breast cancer resistance protein) is an efflux protein that plays a role in host detoxification of various xenobiotic substrates, including the irinotecan metabolite 7- ethyl-10-hydroxycamptothecin (SN-38).
Floris A. de Jong +6 more
openaire +2 more sources
Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): The current study aimed to investigate the relationship of genetic polymorphism and plasma methotrexate (MTX) levels, toxicity experience and event free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL).
Mohammad Ali Esmaili +7 more
doaj +1 more source
EXCLI Journal : Experimental and Clinical Sciences, 2023 A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a
Julia de Paula Dutra +11 more
doaj +1 more source
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
Annals of Human Biology, 2022 Background Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs.
Tamara Božina +8 more
doaj +1 more source
Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor
Frontiers in Cell and Developmental Biology, 2021 Overexpression of ATP-binding cassette transporter superfamily G member 2 (ABCG2), is known as a major mechanism mediating multidrug resistance (MDR) in cancer cells.
Zhuo-Xun Wu +8 more
doaj +1 more source