Results 1 to 10 of about 26,096 (220)
Acta Pharmaceutica Sinica B, 2022 Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance (MDR), an obstacle to cancer therapy.
Sabesan Yoganathan +2 more
exaly +3 more sources
Frontiers in Cell and Developmental Biology, 2020 Overexpression of ABCG2 remains a major impediment to successful cancer treatment, because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes clinical multidrug resistance (MDR).
Li-Zhu Lin, Dong-Hua Yang, Ning Ji
exaly +3 more sources
Redox BiologyThe transporter protein ABC subfamily G member 2 (ABCG2) is implicated in epilepsy; however, its specific role remains unclear. In this study, we assessed changes in ABCG2 expression and its role in epilepsy both in vitro and in vivo.
Zhi-Ping Li, Yongmin Chen
exaly +3 more sources
Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): The current study aimed to investigate the relationship of genetic polymorphism and plasma methotrexate (MTX) levels, toxicity experience and event free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL).
Mohammad Ali Esmaili +7 more
doaj +1 more source
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
Annals of Human Biology, 2022 Background Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs.
Tamara Božina +8 more
doaj +1 more source
EXCLI Journal : Experimental and Clinical Sciences, 2023 A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a
Julia de Paula Dutra +11 more
doaj +1 more source
Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor
Frontiers in Cell and Developmental Biology, 2021 Overexpression of ATP-binding cassette transporter superfamily G member 2 (ABCG2), is known as a major mechanism mediating multidrug resistance (MDR) in cancer cells.
Zhuo-Xun Wu +8 more
doaj +1 more source
OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance
Frontiers in Pharmacology, 2021 OTS964 is a potent T-LAK cell-originated protein kinase (TOPK) inhibitor. Herein, we investigated the interaction of OTS964 and multidrug resistance (MDR)-associated ATP-binding cassette sub-family G member 2 (ABCG2).
Yuqi Yang +8 more
doaj +1 more source
Pharmacokinetics and Pharmacogenetics of Apixaban
Рациональная фармакотерапия в кардиологии, 2020 Apixaban is oral anticoagulant, it is widely used in prevention of stroke in non-valvular atrial fibrillation and treatment of deep vein thrombosis and pulmonary embolism. Its main mechanism of action is through reversible inhibition of factor Xa.
A. V. Savinova +4 more
doaj +1 more source
Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells. [PDF]
PLoS ONE, 2010 Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays a key role in multidrug resistance and protecting cancer stem cells. ABCG2-knockout had no apparent adverse effect on the development, biochemistry, and life of mice.
Hui Peng +3 more
doaj +1 more source