Results 1 to 10 of about 1,971,906 (181)

The human ATP-binding cassette (ABC) transporter superfamily [PDF]

Human Mutation, 2022
The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra- and intra-cellular membranes. Mutations in ABC genes cause 21 human disorders or phenotypes with Mendelian inheritance, including cystic fibrosis, adrenoleukodystrophy, retinal degeneration, cholesterol, and
Karobi Moitra, Rando Allikmets, Michael Dean   +2 more
exaly   +6 more sources

ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter [PDF]

eLife
ATP-binding cassette (ABC) transporters are essential molecular machines whose conformational dynamics have largely been inferred from ensemble-averaged measurements.
Matija Pečak, Christoph Nocker, Robert Tampé   +2 more
doaj   +2 more sources

Noncanonical role for the binding protein in substrate uptake by the MetNI methionine ATP Binding Cassette (ABC) transporter [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Jens T Kaiser, Douglas C. Rees, Jeffrey Y Lai   +2 more
exaly   +2 more sources

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

Nature Communications, 2022
Ycf1, a C-family member ATP Binding Cassette (ABC) transporter, transports glutathione and glutathione-metal complexes in yeast. Here the authors use cryo-EM and biochemical analysis to show how an intrinsically-disordered regulatory domain (R-domain ...
Nitesh Kumar Khandelwal, Cinthia R. Millan, Samantha I. Zangari, Samantha Avila, Dewight Williams, Tarjani M. Thaker, Thomas M. Tomasiak   +6 more
doaj   +1 more source

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease

Nature Communications, 2021
ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidenephosphatidylethanolamine (N-Ret-PE) to the cytoplasmic leaflet of photoreceptor membranes. ABCA4 mutations are associated with loss of vision.
Jessica Fernandes Scortecci, Laurie L. Molday, Susan B. Curtis, Fabian A. Garces, Pankaj Panwar, Filip Van Petegem, Robert S. Molday   +6 more
doaj   +1 more source

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

eLife, 2021
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan, Richard Obexer, Susanne Hofmann, Khanh Vu Huu, Yichao Huang, Nina Morgner, Hiroaki Suga, Robert Tampé   +7 more
doaj   +1 more source

CLONING OF A GENE ENCODING PROTEIN BELONGING TO ABC TRANSPORTER INVOLVED IN BACTERIAL MAGNETIC PARTICLE SYNTHESIS IN MAGNETOSPIRILLUM MAGNETICUM AMB-1

Biotropia: The Southeast Asian Journal of Tropical Biology, 2009
Magnetospirillum magneticum AMB-1 synthesizes intracellular magnetic particles, magnetite (Fe3 O4 ), enveloped by membrane called magnetosome under micro-aerobic conditions.
ARIS TRI WAHYUDI
doaj   +3 more sources

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

eLife, 2020
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters, responsible for many physiological processes and human maladies.
Erich Stefan, Susanne Hofmann, Robert Tampé   +2 more
doaj   +1 more source

Molecular interaction of nitrate transporter proteins with recombinant glycinebetaine results in efficient nitrate uptake in the cyanobacterium Anabaena PCC 7120.

PLoS ONE, 2021
Nitrate transport in cyanobacteria is mediated by ABC-transporter, which consists of a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD).
Prashant Swapnil, Mukesh Meena, Ashwani K Rai   +2 more
doaj   +2 more sources

Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins

Nature Communications, 2021
In Gram-negative bacteria, lipoproteins are transported from the inner membrane (IM) to the outer membrane (OM) by the ATP-binding cassette (ABC) transporter LolCDE.
Stuti Sharma, Ruoyu Zhou, Li Wan, Shan Feng, KangKang Song, Chen Xu, Yanyan Li, Maofu Liao   +7 more
doaj   +1 more source