Results 21 to 30 of about 1,971,906 (181)
The ATP binding cassette (ABC) transport systems ofMycobacterium tuberculosis [PDF]
FEMS Microbiology Reviews, 2000 We have undertaken the inventory and assembly of the typical subunits of the ABC transporters encoded by the complete genome of Mycobacterium tuberculosis. These subunits, i.e. the nucleotide binding domains (NBDs), the membrane-spanning domains (MSDs) and the substrate binding proteins (SBPs), were identified on the basis of their characteristic ...
Braibant, Martine +2 more
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Investigation of the Function and Regulation of ABC Transporters [PDF]
, 2014 The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorATP-Binding-Cassette (ABC) transporters are primary active pumps that typically ...
Akkaya, Begum Gokcen
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ATP-binding cassette (ABC) transporters in normal and pathological lung [PDF]
Respiratory Research, 2005 Abstract ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) are
van der Deen, M. +5 more
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Mechanistic diversity in ATP-binding cassette (ABC) transporters [PDF]
Nature Structural & Molecular Biology, 2016 ABC transporters catalyze transport reactions, such as the high-affinity uptake of micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells. Crystal structures of ABC domains and full transporters have provided a framework for formulating reaction mechanisms of ATP-driven substrate transport, but recent studies have ...
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Detergent-free purification of ABC (ATP-binding-cassette) transporters [PDF]
Biochemical Journal, 2014 ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these proteins is often hampered by their large size and membrane location. Membrane protein purification usually utilizes detergents to solubilize the protein from the membrane, effectively removing ...
Gulati, S. +13 more
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Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter. [PDF]
J Biol Chem, 2016 ATP-binding cassette transporters use an alternating access mechanism to move substrates across cellular membranes. This mode of transport ensures the selective passage of molecules while preserving membrane impermeability. The crystal structures of MalFGK2, inward- and outward-facing, show that the transporter is sealed against ions and small ...
Carlson ML, Bao H, Duong F.
europepmc +4 more sources
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
Computational and Structural Biotechnology Journal, 2021 The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression.
Vigneshwaran Namasivayam +3 more
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The allosteric regulatory mechanism of the Escherichia coli MetNI methionine ATP binding cassette (ABC) transporter. [PDF]
J Biol Chem, 2015 The MetNI methionine importer of Escherichia coli, an ATP binding cassette (ABC) transporter, uses the energy of ATP binding and hydrolysis to catalyze the high affinity uptake of d- and l-methionine.
Yang JG, Rees DC.
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, 2012 ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
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Beni-Suef University Journal of Basic and Applied Sciences, 2019 Background ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes.
Indira Mikkili +4 more
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