Results 41 to 50 of about 1,971,906 (181)

Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1

Nature Communications, 2019
P-glycoprotein, an ATP-binding cassette (ABC) transporter, extrudes a large variety of xenobiotics from the cell which protects tissues from toxins.
Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Matsuoka, Yasuhisa Kimura, Kazumitsu Ueda, Hiroaki Kato   +6 more
doaj   +1 more source

Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. [PDF]

PLoS ONE, 2011
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps.
Ayako Nakano, Daisuke Tsuji, Hirokazu Miki, Qu Cui, Salah Mohamed El Sayed, Akishige Ikegame, Asuka Oda, Hiroe Amou, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kyoko Takeuchi, Akira Sakai, Shuji Ozaki, Kazuma Okano, Takahiro Nakamura, Kohji Itoh, Toshio Matsumoto, Masahiro Abe   +19 more
doaj   +1 more source

Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter

Computational and Structural Biotechnology Journal, 2021
The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is known about its structure and drug-binding sites.
Lokeswari P. Tangella, Mahreen Arooj, Evelyne Deplazes, Elin S. Gray, Ricardo L. Mancera   +4 more
doaj   +1 more source

ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma [PDF]

Journal of Neuro-Oncology, 2018
ATP-binding cassette transporters (ABC transporters) regulate traffic of multiple compounds, including chemotherapeutic agents, through biological membranes. They are expressed by multiple cell types and have been implicated in the drug resistance of some cancer cells.
Dréan, Antonin, Rosenberg, Shai, Lejeune, François-Xavier, Goli, Larissa, Nadaradjane, Aravindan Arun, Guehennec, Jeremy, Schmitt, Charlotte, Verreault, Maïté, Bielle, Franck, Mokhtari, Karima, Sanson, Marc, Carpentier, Alexandre, Delattre, Jean-Yves, Idbaih, Ahmed   +13 more
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Characterizing ABC-Transporter Substrate-Likeness Using a Clean-Slate Genetic Background

Frontiers in Pharmacology, 2019
Mutations in ATP Binding Cassette (ABC)-transporter genes can have major effects on the bioavailability and toxicity of the drugs that are ABC-transporter substrates.
Artem Sokolov, Stephanie Ashenden, Stephanie Ashenden, Nil Sahin, Nil Sahin, Richard Lewis, Nurdan Erdem, Elif Ozaltan, Andreas Bender, Frederick P. Roth, Frederick P. Roth, Frederick P. Roth, Murat Cokol, Murat Cokol, Murat Cokol, Murat Cokol   +15 more
doaj   +1 more source

Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family [PDF]

, 2008
Wagner H, Morgenstern B, Dress A. Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family. Algorithms for Molecular Biology.
Andreas Dress, Wagner Holger, Burkhard Morgenstern, Dress Andreas, Morgenstern Burkhard, Wagner, Holger, Dress, Andreas, Holger Wagner, Morgenstern, Burkhard   +8 more
core   +1 more source

Nucleotide-induced conformational dynamics in ABC transporters from structure-based coarse grained modelling.

Frontiers in Physics, 2016
ATP-binding cassette (ABC) transporters are integral membrane proteins which mediate the exchange of diverse substrates across membranes powered by ATP molecules.
Holger eFlechsig
doaj   +1 more source

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance

Molecules, 2023
The discovery of the first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by ...
Jiahui Huang, Gerhard F. Ecker
doaj   +1 more source

A Review on ATP Binding Cassette (ABC ) Transporters

, 2017
ATP binding cassette (ABC) transporters form a special famil of membrane proteins, characterized by homologous ATP - binding, and large, multispanningtransmembrane domains. Several members of this family are primary active transporters, which signi ficantly modulate the absorption, metabolism, cellular effectivity and toxicity of pharmacological agents.
Gizaw Mamo, 1, , Anandakuma, R Pandi, 2
openaire   +1 more source

Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters

FEBS Letters, 1997
A group of ATP‐binding cassette (ABC) transporters, including the yeast cadmium transporter (YCF1), the mammalian multidrug resistance‐associated protein (MRP), the multispecific organic anion transporter and its congener (MOAT and EBCR), as well as the sulfonylurea receptor (SUR), group into a subfamily by sequence comparison.
Tusnády, Gábor E, Bakos, Éva, Váradi, András, Sarkadi, Balázs   +3 more
openaire   +2 more sources