Results 61 to 70 of about 1,971,906 (181)

Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

Annals of Thoracic Medicine, 2012
The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer ...
Taras Gout
doaj   +1 more source

Mechanistic insights into ATP hydrolysis by the ABC transporter TAP [PDF]

, 2004
The transporter associated with antigen processing (TAP) plays a pivotal role in the adaptive immune response against virus-infected or malignantly transformed cells.
Chen, Min
core  

Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat

Pharmaceutics, 2023
Background: ATP-binding cassette (ABC) transporters comprise a superfamily of genes encoding membrane proteins with nucleotide-binding domains (NBD).
Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Ziying Liu, Caroline Sodja, Sonia Leclerc, Ewa Baumann, Christie E. Delaney, Eric Brunette, Danica B. Stanimirovic   +9 more
doaj   +1 more source

Staphylococcal accessory regulator SarA-mediated modulation of autolysis and surface charge enables Staphylococcus aureus to evade vancomycin killing

mSystems
Staphylococcus aureus is a major source of community and nosocomial infections. Due to the extensive application of antibiotics, S. aureus has developed resistance to antibiotics, especially vancomycin, making clinical treatment challenging ...
Yujie Li, Shihui Yuan, Ping Yan, Shupei Zhai, Zhien He, Huimin Su, Zhongliang Zhu, Qingze He, Weifeng Xu, Baolin Sun   +9 more
doaj   +1 more source

Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Frontiers in Pharmacology, 2022
Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique
Zhuo-fen Deng, Irina Bakunina, Hua Yu, Jaehong Han, Alexander Dömling, Maria-José U Ferreira, Jian-ye Zhang   +6 more
doaj   +1 more source

Genome-wide analysis of ATP binding cassette (ABC) transporters in tomato

PLOS ONE, 2018
ATP binding cassette (ABC) transporters are proteins that actively mediate the transport of a wide range of molecules, such as organic acids, metal ions, phytohormones and secondary metabolites. Therefore, ABC transporters must play indispensable roles in growth and development of tomato, including fruit development.
Peter Amoako Ofori, Ayaka Mizuno, Mami Suzuki, Enrico Martinoia, Stefan Reuscher, Koh Aoki, Daisuke Shibata, Shungo Otagaki, Shogo Matsumoto, Katsuhiro Shiratake   +9 more
openaire   +5 more sources

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

Nature Communications
ATP-binding cassette (ABC) transporters use ATP to transport substrates across membranes. In type IV ABC transporters, which include many multidrug resistance (MDR) pumps, communication between nucleotide-binding domains (NBDs) and transmembrane domains (
Victor Hugo Pérez Carrillo, Margot Di Cesare, Dania Rose-Sperling, Waqas Javed, Hannes Neuweiler, Julien Marcoux, Cédric Orelle, Jean-Michel Jault, Ute A. Hellmich   +8 more
doaj   +1 more source

Inhibitors of ABCB1 and ABCG2 overcame resistance to topoisomerase inhibitors in small cell lung cancer

Thoracic Cancer, 2022
Background Small cell lung cancer (SCLC) is a highly aggressive disease with a poor prognosis. Although most patients initially respond to topoisomerase inhibitors, resistance rapidly emerges.
Miwako Omori, Rintaro Noro, Masahiro Seike, Kuniko Matsuda, Mariko Hirao, Aya Fukuizumi, Natsuki Takano, Akihiko Miyanaga, Akihiko Gemma   +8 more
doaj   +1 more source

Not Just Transporters: Alternative Functions of ABC Transporters in Bacillus subtilis and Listeria monocytogenes

Microorganisms, 2021
ATP-binding cassette (ABC) transporters are usually involved in the translocation of their cognate substrates, which is driven by ATP hydrolysis. Typically, these transporters are required for the import or export of a wide range of substrates such as ...
Jeanine Rismondo, Lisa Maria Schulz
doaj   +1 more source

A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle [PDF]

Molecular Cell, 2003
The ATPase components of ATP binding cassette (ABC) transporters power the transporters by binding and hydrolyzing ATP. Major conformational changes of an ATPase are revealed by crystal structures of MalK, the ATPase subunit of the maltose transporter from Escherichia coli, in three different dimeric configurations.
Chen, Jue, Lu, Gang, Lin, Jeffrey, Davidson, Amy L, Quiocho, Florante A   +4 more
openaire   +2 more sources