Results 71 to 80 of about 1,971,906 (181)

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

Frontiers in Oncology, 2019
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic.
Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source

Impact of ex vivo cell culturing on ABC transporters’ expression and drug sensitivity in patient-derived non-small cell lung cancer models

Oncologie
Non-small cell lung cancer (NSCLC) treatment is complicated by interactions between cancer and stromal cells, as well as drug resistance linked to ATP-binding cassette (ABC) transporters.
Dinić Jelena, Jovanović Stojanov Sofija, Lupšić Ema, Pajović Milica, Stepanović Ana, Dragoj Miodrag, Podolski-Renić Ana, Pešić Milica   +7 more
doaj   +1 more source

ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

Cancer Cell International, 2005
One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of ...
Choi Cheol-Hee
doaj   +1 more source

ATP‐binding cassette (ABC) transporter expression and localization in sea urchin development [PDF]

Developmental Dynamics, 2012
AbstractBackground: ATP‐binding cassette (ABC) transporters are membrane proteins that regulate intracellular concentrations of myriad compounds and ions. There are >100 ABC transporter predictions in the Strongylocentrotus purpuratus genome, including 40 annotated ABCB, ABCC, and ABCG “multidrug efflux” transporters.
Lauren E, Shipp, Amro, Hamdoun
openaire   +2 more sources

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

, 2013
ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress.
Gileadi, O., Li, Q., Yang, J., von Delft, F., Bullock, A.N., Barr, A. J., Ross, J., Sansom, M. S. P., Carpenter, E. P., Carpenter, E.P., Kim, J-I., Barr, A.J., Burgess-Brown, N.A., Shintre, C. A., Berridge, G., Marsden, B., Stansfeld, P.J., Sansom, M.S.P., Burgess-Brown, N. A., Bountra, C., Shrestha, L., Shintre, C.A., Goubin, S., Bullock, A. N., Pike, A. C. W., Kim, J.I., Pike, A.C.W., Edwards, A.M., Stansfeld, Phillip J., Edwards, A. M., Marsden, B. D.   +30 more
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Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2 [PDF]

Journal of Biological Chemistry, 2004
Human ATP-binding cassette G2 (ABCG2, also known as mitoxantrone resistance protein, breast cancer-resistance protein, ABC placenta) is a member of the superfamily of ATP-binding cassette (ABC) transporters that have a wide variety of substrates. Overexpression of human ABCG2 in model cancer cell lines causes multidrug resistance by actively effluxing ...
Junkang, Xu, Yang, Liu, Youyun, Yang, Susan, Bates, Jian-Ting, Zhang   +4 more
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MOESM7 of Structural and functional insights into the Diabrotica virgifera virgifera ATP-binding cassette transporter gene family

, 2019
Additional file 7.
Folukemi Adedipe (3508040), Marcé Lorenzen (8056631), Brian Wiegmman (8056628), Brad Coates (575729), Nathaniel Grubbs (397043)   +4 more
core   +1 more source

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]

, 2013
A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba, Vergani P, Töröcsik, B, Csanády, László, Csanády László, Mihályi, C, Csaba Mihályi, Paola Vergani, Vergani, Paola, Beáta Töröcsik, Szollosi, A, László Csanády, Szőllősi, András, Szöllősi András, Törőcsik, Beáta, Mihályi, Csaba, Andras Szollosi, Vergani, P, Törőcsik Beáta, Csanády, L   +19 more
core   +1 more source

A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance

Cells, 2019
Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes.
Megumi Tsukamoto, Miho Yamashita, Tsuyoshi Nishi, Hiroshi Nakagawa   +3 more
doaj   +1 more source

Human ATP-binding cassette (ABC) transporters and lipoprotein metabolism.

Physiological Research, 2004
The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of substrates including amino acids, lipids, inorganic ions, peptides, saccharides, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the
J Štefková, R Poledne, JA Hubáček
openaire   +1 more source