Results 81 to 90 of about 1,971,906 (181)

The details and entropy demons in a transmembrane allosteric machine.

PLoS Biology
In the model gram-negative bacterium Escherichia coli, three of the four Type VII ATP-binding cassette (ABC) transporter systems have been well characterized structurally and functionally. A new study reports the cryo-EM structures of the fourth Type VII
Ben F Luisi
doaj   +1 more source

Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Molecular Cancer, 2018
Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no commercial available MDR modulator approved by FDA was used in clinic.
Shaocong Wu, Liwu Fu
doaj   +1 more source

Regulation of ATP‐binding cassette (Abc) transporters by organoselenium compounds

The FASEB Journal, 2008
Selenium‐containing compounds have demonstrated chemopreventive activity in a variety of chemically‐induced tumor models, but a unifying mechanism for this effect remains elusive. Altered disposition of chemicals and toxic metabolites may be contributing factors.
Dorinda D Arch, Wael M El‐Sayed, Tarek Aboul‐Fadl, Jeannette C Roberts, Michael R Franklin   +4 more
openaire   +1 more source

Structure of WbdD : a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a [PDF]

, 2012
The Escherichia coli serotype O9a O-antigen polysaccharide (O-PS) is a model for glycan biosynthesis and export by the ATP-binding cassette transporter-dependent pathway.
James H. Naismith, Gregor Hagelueken, Bradley R. Clarke, Hagelueken, Gregor, Huang, Hexian, Chris Whitfield, Clarke, Bradley R., Whitfield, Chris, Tomas Lebl, Lebl, Tomas, Naismith, James H., Hexian Huang, Lebl, Tomas; id_orcid   +12 more
core   +1 more source

Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti

Memorias do Instituto Oswaldo Cruz, 2014
The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by ...
Estelita Pereira Lima, Marília Oliveira Fonseca Goulart, Modesto Leite Rolim Neto   +2 more
doaj   +1 more source

The effect of ATP-binding cassette (ABC) transporters in human cancers

International Journal of Science Letters, 2019
Multi-drug resistance (MDR) can be defined as a negative effect on the drug-target relationships, decreasing in intracellular drug aggregation. ABC (ATP-binding cassette) are popular transporter proteins in the development of MDR. ABC proteins in the cell membrane structure reduce the therapeutic efficacy and cause drug resistance in cancer patients ...
Seda MESCİ, Sevgi MARAKLİ, Burak YAZGAN, Tuba YILDIRIM   +3 more
openaire   +4 more sources

Funktionelle Rekonstitution des menschlichen lysosomale Peptid-Transporter TAPL zeigt die Substratspezifität [PDF]

, 2009
The transporter associated with antigen processing-like (TAPL) acts as a lysosomal ATP-dependent polypeptide transporter with broad length selectivity. To characterize in detail its substrate specificity, a procedure for solubilization, purification and ...
Zhao, Chenguang
core  

The yeast plasma membrane ATP binding cassette (ABC) transporter aus1

, 2011
The ATP binding cassette (ABC) transporter Aus1 is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae and is required for sterol uptake. These observations suggest that Aus1 promotes the translocation
Herrmann, A., Dittmar, G., Marek, M., Gunnar Dittmar, Marek, Magdalena, Günther-Pomorski, Thomas, Gabriele Schreiber, Schreiber, Gabriele, Magdalena Marek, Daleke, D.L., Sigrid Milles, Schreiber, G., Thomas Günther Pomorski, Milles, S., Mueller, P., Müller, Peter, Herrmann, Andreas, Milles, Sigrid, Andreas Herrmann, Daleke, David L., Peter Müller, David L. Daleke, Pomorski, T.G., Dittmar, Gunnar   +23 more
core   +1 more source

Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter

Nature Communications
ATP-binding cassette (ABC) transporters are molecular machines involved in diverse physiological processes, including antigen processing by TAP, a key component of adaptive immunity.
Christoph Nocker, Matija Pečak, Tobias Nocker, Amin Fahim, Lukas Sušac, Robert Tampé   +5 more
doaj   +1 more source

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations [PDF]

, 2010
CFTR, the ABC protein defective in cystic fibrosis, functions as an anion channel. Once phosphorylated by protein kinase A, a CFTR channel is opened and closed by events at its two cytosolic nucleotide binding domains (NBDs).
Gadsby, DC, Csanady, L, Vergani, P
core