Results 101 to 110 of about 1,971,906 (181)

ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia [PDF]

The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins, some of which are of notable physiological and clinical importance.
Harris, Neil, Neil Harris, Tung Wynn, Reema Kashif, Ogunbileje, John O., Kashif, Reema, Stover, Brian, Bremansu Osa-Andrews, Wynn, Tung, Osa-Andrews, Bremansu, Brian Stover, John O. Ogunbileje   +11 more
core   +1 more source

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters

Nature Communications
SbmA is a membrane transporter from Escherichia coli that imports antimicrobial peptides. SbmA belongs to the SbmA-like peptide transporter (SLiPT) family.
Thijs W. Ettema, Satomi Inaba-Inoue, Chancievan Thangaratnarajah, Leticia Alves da Silva, Nikas Senning, Amy Clarke, Piotr Stepien, Anokhi Shah, Yue Ma, Katie Hardman, Sophia David, Hassane El Mkami, Jonathan G. Heddle, Norimichi Nomura, Satoshi Ogasawara, So Iwata, Dmitry Ghilarov, Christos Pliotas, Thomas Stockner, Dirk J. Slotboom, Konstantinos Beis   +20 more
doaj   +1 more source

A highly conserved ABC transporter mediates cello-oligosaccharide uptake in the extremely thermophilic, lignocellulolytic bacterium Anaerocellum bescii (f. Caldicellulosiruptor bescii)

Applied and Environmental Microbiology
Cellulose deconstruction and utilization are foundational to renewable biofuel and biochemical production. Anaerocellum bescii (formerly Caldicellulosiruptor bescii) is an extremely thermophilic cellulolytic bacterium, notable for its multi-domain ...
Hansen Tjo, Virginia Jiang, Anherutowa Calvo, Jerelle A. Joseph, Jonathan M. Conway   +4 more
doaj   +1 more source

ABC transporter-facilitated ATP conductive transport

, 1999
The concept that the cystic fibrosis (CF) transmembrane conductance regulator, the protein product of the CF gene, can conduct larger multivalent anions such as ATP as well as Cl−is controversial.
Erik M. Schwiebert
core   +1 more source

ATP-Binding Cassette (ABC) Transporter Genes in Plant-Parasitic Nematodes: An Opinion for Development of Novel Control Strategy. [PDF]

Front Plant Sci, 2020
Kooliyottil R, Rao Gadhachanda K, Solo N, Dandurand LM.   +3 more
europepmc   +1 more source

Genome-wide identification of ATP binding cassette (ABC) transporter and heavy metal associated (HMA) gene families in flax (Linum usitatissimum L.). [PDF]

BMC Genomics, 2020
Khan N, You FM, Datla R, Ravichandran S, Jia B, Cloutier S.   +5 more
europepmc   +1 more source

Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation

Nature Communications
Multidrug transport by ATP binding cassette (ABC) exporters entails a mechanism to modulate drug affinity across the transport cycle. Here, we combine cryo-EM and molecular dynamics (MD) simulations to illuminate a lipid-competition mechanism to drive ...
Qingyu Tang, Matt Sinclair, Paola Bisignano, Yunsen Zhang, Emad Tajkhorshid, Hassane S. Mchaourab   +5 more
doaj   +1 more source

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy

, 2003
The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents.
Tirona, Rommel G, Kim, Richard B, Lockhart, A Craig   +2 more
core   +3 more sources

Characterisation of ATP-binding cassette (ABC) transporters in the Calu-3 human bronchial epithelial cell culture model

, 2010
Expression and functionality of ATP-binding cassette (ABC) transporters were assessed in Calu-3 cell monolayers cultured at an air-liquid interface. Transporter gene expression was in agreement with published data in human lungs with the exception of ...
Zann, Vanessa, Brown, Alan, Cooper, Anne, Pritchard, David, Bosquillon, Cynthia, Hutter, Victoria, Hilgendorf, Constanze   +6 more
core   +2 more sources

ATP-binding cassette (ABC) transporters in human metabolism and diseases.

Physiological research, 2005
The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of substrates including amino acids, lipids, inorganic ions, peptides, saccharides, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the
J, Stefková, R, Poledne, J A, Hubácek
openaire   +1 more source