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Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies [PDF]

open access: yesMolecules, 2022
Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents.
Alessia Catalano   +8 more
doaj   +10 more sources

MULTIDRUG RESISTANCE (MDR) OF V. Parahaemolyticus

open access: yesJurnal Riset Kimia, 2015
Vol. 2, No. 2   ABSTRACT   A total of 97 V. parahaemolyticus isolate from Padang were examined for their resistance to 15 antibiotics. V. parahaemolyticus isolated behaved as resistant to sulfamethoxazole (100%), rifampin (95%) and tetracycline (75%) and 
Marlina -
doaj   +4 more sources

Epidemiology and predictors of multidrug-resistant Enterobacteriaceae in intensive care units of a tertiary hospital in Somalia: a five-year retrospective study (2019–2024) [PDF]

open access: yesFrontiers in Antibiotics
BackgroundMultidrug-resistant Enterobacteriaceae (MDRE) represent a critical threat in intensive care units, particularly in low- and middle-income countries, where surveillance data remain scarce. This study characterized the epidemiology and predictors
Omar Sidow Zubair   +8 more
doaj   +2 more sources

Characterization of a Conjugative Multidrug Resistance IncP-2 Megaplasmid, pPAG5, from a Clinical Pseudomonas aeruginosa Isolate

open access: yesMicrobiology Spectrum, 2022
The spread of resistance genes via horizontal plasmid transfer plays a significant role in the formation of multidrug-resistant (MDR) Pseudomonas aeruginosa strains. Here, we identified a megaplasmid (ca.
Meng Li   +6 more
doaj   +1 more source

An epidemiological study of the predictors of multidrug resistance and methicillin resistance among Staphylococcus spp. isolated from canine specimens submitted to a diagnostic laboratory in Tennessee, USA [PDF]

open access: yesPeerJ, 2023
Background Understanding drivers of multidrug resistance (MDR) and methicillin resistance, which have increased among canine staphylococcal isolates, is essential for guiding antimicrobial use practices.
Jennifer Lord   +5 more
doaj   +2 more sources

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli

open access: yesBiology, 2022
Infections caused by multidrug resistance (MDR) of Gram-negative bacteria have become one of the most severe public health problems worldwide. The main mechanism that confers MDR to bacteria is drug efflux pumps, as they expel a wide range of compounds ...
Rawaf Alenazy
doaj   +1 more source

Role of membrane-embedded drug efflux ABC transporters in the cancer chemotherapy

open access: yesOncology Reviews, 2020
One of the major problems being faced by researchers and clinicians in leukemic treatment is the development of multidrug resistance (MDR) which restrict the action of several tyrosine kinase inhibitors (TKIs).
Sonu Kumar Gupta   +3 more
doaj   +1 more source

Risk factors for multidrug resistance in tuberculosis patients with diabetes mellitus

open access: yesBMC Infectious Diseases, 2022
Objective To study the risk factors and prediction models of multidrug resistance in patients with tuberculosis and diabetes and those with a history of tuberculosis treatment.
Shuangping Li, Yalin Liang, Xinjun Hu
doaj   +1 more source

The prevalence of antibiotic-resistant and multidrug-resistant bacteria in urine cultures from inpatients with spinal cord injuries and disorders: an 8-year, single-center study

open access: yesBMC Infectious Diseases, 2022
Background Patients, especially inpatients, with spinal cord lesions and disorders (SCI/D) have an elevated risk of recurrent urinary tract infections with multidrug resistant (MDR) bacteria.
Vladimír Šámal   +4 more
doaj   +1 more source

Spread of Multidrug-Resistant Rhodococcus equi, United States

open access: yesEmerging Infectious Diseases, 2021
Multidrug resistance has been detected in the animal and zoonotic human pathogen Rhodococcus equi after mass macrolide/rifampin antibioprophylaxis in endemically affected equine farms in the United States. Multidrug-resistant (MDR) R.
Sonsiray Álvarez-Narváez   +4 more
doaj   +1 more source

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