Results 41 to 50 of about 2,438,474 (193)

The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer [PDF]

open access: yes, 2003
Galectin-3 is an apoptosis-related gene previously found to be over-expressed in invasive tumours and to cause in v itroinvasiveness and metastasis in colon, breast and thyroid follicular cancer cells.
Linehan, Rasha
core   +2 more sources

Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients. [PDF]

open access: yes, 2012
Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of the type, number, and duration of drugs used ...
Neel Gandhi (139419)   +452 more
core   +1 more source

A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas

open access: yesNature Communications, 2020
The emergence of multidrug resistance (MDR) in bacteria represents a global threat to human health. Here, Cazares et al. identify a family of MDR megaplasmids carrying large arrays of antibiotic resistance genes in Pseudomonas strains from various ...
Adrian Cazares   +10 more
doaj   +1 more source

Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success

open access: yesAdvances in Cancer Biology - Metastasis
A significant obstacle to treating cancer is multidrug resistance (MDR), which is the capacity of cancerous cells to develop resistance to both traditional and cutting-edge chemotherapeutic treatments.
Sumel Ashique   +8 more
doaj   +1 more source

Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM) : study protocol for a randomized controlled trial [PDF]

open access: yes, 2014
Background In contrast to drug-sensitive tuberculosis, the guidelines for the treatment of multi-drug-resistant tuberculosis (MDR-TB) have a very poor evidence base; current recommendations, based on expert opinion, are that patients should be treated ...
Squire, Stephen Bertel   +25 more
core   +2 more sources

Decreasing prevalence of multi-drugs resistant Mycobacterium tuberculosis in Nashik City, India [PDF]

open access: yesJournal of Microbiology and Infectious Diseases, 2013
Objective: In India, increasing prevalence of multi-drug resistant tuberculosis (MDR) has aggravated the control oftuberculosis problem. In many urban and semi-urban regions of India, no surveillance data of multidrug resistance inMycobacterium ...
Arun P. More   +2 more
doaj   +1 more source

The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs

open access: yesMembranes, 2023
Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC) transporter group play a crucial role in the export of cytotoxic drugs across cell membranes.
Shadi A Badiee   +3 more
doaj   +1 more source

Transmission of multidrug-resistant tuberculosis in the UK: a cross-sectional molecular and epidemiological study of clustering and contact tracing [PDF]

open access: yes, 2014
BACKGROUND: Between 2000 and 2012 the number of multidrug-resistant (MDR) tuberculosis cases in the UK increased from 28 per year to 81 per year. We investigated the proportion of MDR tuberculosis cases arising from transmission in the UK and associated ...
Watson, JP   +6 more
core  

Modulation of multidrug resistance (MDR) in hematological malignancies

open access: yesAnnals of Oncology, 1999
The term multidrug resistance (MDR) describes the observation that tumour cell lines can become cross-resistant to several structurally unrelated chemotherapeutic agents after exposure to a single cytotoxic drug. In hematological malignancies, MDR is most often associated with overexpression of P-gp, a 170-kd transmembrane glycoprotein encoded by the ...
openaire   +2 more sources

Trends and characteristics of multidrug-resistant MRSA in Norway 2008-2020

open access: yesFrontiers in Microbiology
Infections caused by multidrug-resistant (MDR) bacteria are recognized as a critical One Health concern which poses a significant threat to public health, leading to increased morbidity and mortality across both high- and low-income countries.
Torunn Gresdal Rønning   +6 more
doaj   +1 more source

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