Results 51 to 60 of about 2,438,474 (193)
Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
, 2007 Multidrug resistance (MDR) describes the phenomenon whereby cancer cellsexposed to a single cytotoxic drug develop cross resistance to numerous otherstructurally unrelated chemotherapeutics.
Featherstone, Jonathan Mark
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Natural products reverse cancer multidrug resistance
Frontiers in PharmacologyCancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR.
Jia-Yu Zou +12 more
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High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal
BMC Research Notes, 2012 Background Urinary Tract Infection (UTI) is one of the most common infectious diseases and people of all age-groups and geographical locations are affected.
Baral Pankaj +5 more
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Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo [PDF]
, 2004 In gene therapy, a clinically relevant therapeutic effect requires long-term expression of the desired gene at a level sufficient to correct or at least alleviate the underlying gene defect.
Pfützner, Wolfgang, Vogel, Jonathan C.
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Cellular & Molecular Biology Letters, 2018 Adjuvant chemotherapy has become the frequently adopted standard therapeutic approach for non-small cell lung cancer (NSCLC). However, the development of multidrug resistance (MDR) is a major obstacle contributing to the failure of chemotherapy.
Huaping Huang +7 more
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Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR [PDF]
Proceedings of the National Academy of Sciences, 2011 Current views of multidrug (MD) recognition focus on large drug-binding cavities with flexible elements. However, MD recognition in BmrR is supported by a small, rigid drug-binding pocket. Here, a detailed description of MD binding by the noncanonical BmrR protein is offered through the combined use of X-ray and solution studies.
Sharrol, Bachas +3 more
openaire +2 more sources
Chinese Journal of Lung Cancer, 2009 Background and objective It has been proven that chemotherapy failure caused by multidrug resistance in lung tumor cells is the main cause for the patient's survival rate.
Yongcheng PAN +5 more
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The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods [PDF]
Antimicrobial Resistance & Infection Control, 2019 Abstract Background A multitude of definitions determining multidrug resistance (MDR) of Gram-negative organisms exist worldwide. The definitions differ depending on their purpose and on the issueing country or organization. The MDR definitions of the European Centre for Disease Prevention and Control (ECDC) were primarily chosen to harmonize ...
Aline Wolfensberger +4 more
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Revista do Instituto de Medicina Tropical de São Paulo, 2019 Multidrug resistance (MDR), virulence and transferable elements potentiate Pseudomonas aeruginosa's role as an opportunistic pathogen creating a high risk for public health.
Hectorina Rodulfo +7 more
doaj +1 more source
Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells
Journal of International Medical Research, 2020 Objective Studies have demonstrated that tetrandrine reverses multidrug resistance (MDR) in animal models or cell lines derived from multiple cancer types. We examined the potential MDR reversal activity of tetrandrine in a multidrug-resistant variant of
Yachun Li +4 more
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