Results 21 to 30 of about 26,096 (220)
Clinical Cancer Research, 2004 Abstract Purpose: The ATP-binding cassette transporter ABCG2 (breast cancer resistance protein) is an efflux protein that plays a role in host detoxification of various xenobiotic substrates, including the irinotecan metabolite 7- ethyl-10-hydroxycamptothecin (SN-38).
Floris A. de Jong +6 more
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Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters [PDF]
, 2009 Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however, neither agent induces apoptosis of primitive CML CD34<sup>+</sup> cells.
Holyoake, T.L. +10 more
core +2 more sources
The Inhibitor Ko143 Is Not Specific for ABCG2 [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2015 Imaging ATP-binding cassette (ABC) transporter activity in vivo with positron emission tomography requires both a substrate and a transporter inhibitor. However, for ABCG2, there is no inhibitor proven to be specific to that transporter alone at the blood-brain barrier.
Lora D, Weidner +9 more
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ABCG2 Gene and ABCG2 Protein Expression in Colorectal Cancer—In Silico and Wet Analysis
International Journal of Molecular Sciences, 2023 ABCG2 (ATP-binding cassette superfamily G member 2) is a cell membrane pump encoded by the ABCG2 gene. ABCG2 can protect cells against compounds initiating and/or intensifying neoplasia and is considered a marker of stem cells responsible for cancer growth, drug resistance and recurrence. Expression of the ABCG2 gene or its protein has been shown to be
Aleksandra Sałagacka-Kubiak +5 more
openaire +2 more sources
The Challenge of Exploiting ABCG2 in the Clinic [PDF]
Current Pharmaceutical Biotechnology, 2011 ABCG2, or breast cancer resistance protein (BCRP), is an ATP-binding cassette half transporter that has been shown to transport a wide range of substrates including chemotherapeutics, antivirals, antibiotics and flavonoids. Given its wide range of substrates, much work has been dedicated to developing ABCG2 as a clinical target.
Robert W, Robey +3 more
openaire +2 more sources
ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites [PDF]
, 2023 [EN] The ATP-binding cassette G2 (ABCG2) is an efflux transporter expressed in the apical membrane of cells from a large number of tissues, directly affecting bioavailability, tissue accumulation, and secretion into milk of both xenobiotics and ...
García‐Lino, Alba M. +20 more
core +1 more source
ABCG2 – a transporter for all seasons [PDF]
FEBS Letters, 2004 The human ABCG2 (ABCP/MXR/BCRP) protein is a recently recognized ABC half‐transporter, which forms homodimers in the plasma membrane and actively extrudes a wide variety of chemically unrelated compounds from the cells. This protein protects our cells and tissues against various xenobiotics, with a crucial role in the intestine, liver, placenta, and ...
Sarkadi, Balázs +3 more
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BMC Evolutionary Biology, 2020 Background ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds.
Shengchao Ma +9 more
doaj +1 more source
The ABCG2 resistance network of glioblastoma [PDF]
Cell Cycle, 2009 Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor variant. It exhibits heterogeneity at both the morphologic and genetic levels, with a complex combination of somatic alterations rendering the tumor class difficult to adequately treat. The role of so-called "cancer stem-cells" (CSCs) in the resistance of high-grade gliomas
Anne-Marie, Bleau +2 more
openaire +2 more sources
Potent and selective ABCG2 inhibitors derived from tariquidar [PDF]
, 2013 Three different classes of selective ABCG2 modulator (BCRP, breast cancer resistance protein) derived from the lead structure tariquidar have been prepared in this thesis.
Ochoa Puentes, Cristian
core +1 more source