Results 21 to 30 of about 19,287 (163)
The ABCG2 resistance network of glioblastoma [PDF]
Cell Cycle, 2009 Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor variant. It exhibits heterogeneity at both the morphologic and genetic levels, with a complex combination of somatic alterations rendering the tumor class difficult to adequately treat. The role of so-called "cancer stem-cells" (CSCs) in the resistance of high-grade gliomas
Anne-Marie, Bleau +2 more
openaire +2 more sources
Medicine Science, 2016 Limbal stem cell deficiency has an important position among corneal blindness, it is the second most common cause of blindness in the worldwide.
Cemal Ekici, Cumali Degirmenci
doaj +1 more source
Journal of Neuroinflammation, 2020 Background The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribine, and ...
Lisa Thiele née Schrewe +14 more
doaj +1 more source
Czech Journal of Animal Science, 2018 The association between several gene polymorphisms, the estimated breeding values for milk performance traits, and glucose metabolism measured by the glucose tolerance test (GTT) in German Holstein sires were evaluated.
Jindřich Čítek +5 more
doaj +1 more source
M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells
Frontiers in Oncology, 2020 M3814, also known as nedisertib, is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor under phase 2 clinical trials. ABCG2 is a member of the ATP-binding cassette (ABC) transporter family that is closely related to multidrug ...
Zhuo-Xun Wu +11 more
doaj +1 more source
Pharmacogenetics of ABCG2 and Adverse Reactions to Gefitinib [PDF]
JNCI: Journal of the National Cancer Institute, 2006 Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase with activity in non-small-cell lung cancer. Diarrhea and skin toxicity are prominent gefitinib-related adverse events that potentially limit its use. Gefitinib is a substrate for ABCG2 (ABCP, BCRP, MXR), a polymorphic efflux transporter protein that is highly ...
Cusatis, G +10 more
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2022 Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance (MDR), an obstacle to cancer therapy.
Zhuo-Xun Wu +9 more
doaj +1 more source
The influence of ABCG2 polymorphism on erlotinib efflux in the K562 cell line
Pharmacology Research & Perspectives, 2020 Single nucleotide polymorphisms (SNPs) in the gene for multidrug resistance protein ABCG2, an erlotinib transporter, is a possible contributor to the interindividual variation observed in erlotinib pharmacokinetics and toxicity. Therefore, the aim was to
Anna Svedberg +3 more
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Biomedicines, 2023 Colorectal cancer is a common malignant tumor. A major factor in the high mortality rate of colorectal cancer is the emergence of multidrug resistance (MDR). Overexpression of the ABCG2 gene in cancer cells directly leads to MDR.
Ze-Zhong Yu +5 more
doaj +1 more source
Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling. [PDF]
PLoS ONE, 2012 Side population (SP) and ABC transporter expression enrich for stem cells in numerous tissues. We explored if this phenotype characterised human bladder cancer stem cells (CSCs) and attempted to identify regulatory mechanisms.
Anastasia C Hepburn +9 more
doaj +1 more source