Results 31 to 40 of about 19,287 (163)
Frontiers in Cell and Developmental Biology, 2020 Overexpression of ABCG2 remains a major impediment to successful cancer treatment, because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes clinical multidrug resistance (MDR).
Jing-Quan Wang +11 more
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Purification and structural analyses of ABCG2
Advanced Drug Delivery Reviews, 2009 ABCG2 is best known as a multidrug transporter capable of conferring resistance to cancer cells. However, the protein is also inherently expressed in numerous barrier tissues and intriguingly within hematopoietic stem cells. Unlike its partners ABCB1 and ABCC1, there is considerably less information available on the molecular mechanism of ABCG2.
McDevitt, Christopher A. +3 more
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ABCG2 Overexpression Contributes to Pevonedistat Resistance [PDF]
Cancers, 2020 MLN4924 (pevonedistat) is a first-in-class NEDD8-activating enzyme (NAE) inhibitor in clinical trials for the treatment of solid tumors and hematologic malignancies. Despite the promising activity of MLN4924 observed in early trials, drug resistance has been noted in some patients.
Rishil J. Kathawala +8 more
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Adriamycin Induced Chemoresistance of Human TNBC MDA-MB-468 Cells Through Stat3-cMyc Signal Pathway
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the chemoresistance of human triple-negative breast cancer(TNBC) MDA-MB-468 cells induced by adriamycin(ADM) and the underlying mechanism.
XU Jinyuan +7 more
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Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation. [PDF]
PLoS ONE, 2012 Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide ...
Hirotsugu Kobuchi +8 more
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Botryllamides: Natural Product Inhibitors of ABCG2 [PDF]
ACS Chemical Biology, 2009 ABCG2 is a membrane-localized, human transporter protein that has been demonstrated to reduce the intracellular accumulation of substrates through ATP-dependent efflux. Highly expressed in placental syncytiotrophoblasts, brain microvasculature, and the gastrointestinal tract, ABCG2 has been shown to mediate normal tissue protection as well as limit ...
Curtis J, Henrich +8 more
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Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo UniversitetaАктуальность. Фибрилляция предсердий (ФП) является самым распространенным нарушением ритма сердца, которое ассоциировано с повышенным риском тромбоэмболических осложнений.
О. В. Будревич +1 more
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ABCG2 Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban
Drug Design, Development and Therapy, 2023 Hamin Kim,1,* Tae-Jin Song,2,* Jeong Yee,1 Dong-Hyeok Kim,3 Junbeom Park,4 Hye Sun Gwak1 1College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea; 2Department of Neurology, Seoul Hospital, Ewha ...
Kim H +5 more
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Acta Veterinaria, 2018 The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra +4 more
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PLoS Biology, 2023 The eradication of cancer stem cells (CSCs) with drug resistance confers the probability of local tumor control after chemotherapy or targeted therapy. As the main drug resistance marker, ABCG2 is also critical for colorectal cancer (CRC) evolution, in ...
Jiaojiao Hao +14 more
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