Results 51 to 60 of about 26,096 (220)

Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation. [PDF]

PLoS ONE, 2012
Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide ...
Hirotsugu Kobuchi, Koko Moriya, Tetsuya Ogino, Hirofumi Fujita, Keiji Inoue, Taro Shuin, Tatsuji Yasuda, Kozo Utsumi, Toshihiko Utsumi   +8 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Structure of the human multidrug transporter ABCG2 [PDF]

Nature, 2017
ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the pharmacokinetics of commonly used drugs and limits the delivery of therapeutics into tumour cells, thus contributing to multidrug resistance. Here we present the structure of human ABCG2 determined
Taylor, Nicholas M. I. ., Manolaridis, Ioannis, Jackson, Scott M., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.   +5 more
openaire   +5 more sources

ABCG2 Transports the Flukicide Nitroxynil and Affects Its Biodistribution and Secretion into Milk [PDF]

[EN]The ABCG2 transporter plays a key role in pharmacological and toxicological processes, affecting bioavailability, tissue accumulation and milk secretion of its substrates.
Laura Álvarez-Fernández, Blanco Paniagua, Esther, Merino Peláez, Gracia, Esther Blanco-Paniagua, Álvarez Fernández, Laura, Gracia Merino   +5 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

2‐Carboranylquinazoline: The Path to an ABCG2 Inhibitor

ChemMedChem, 2023
AbstractThe role of ATP‐binding cassette (ABC) transporter‐mediated multidrug resistance (MDR) in anti‐cancer therapy is often challenging, frequently leading to inefficiency of treatments. Cancer cells exploit efflux transporters, like the breast cancer resistance protein (BCRP, ABCG2), to secrete chemotherapeutic substances.
Philipp Stockmann, Lydia Kuhnert, Lisa Zörner, Walther Honscha, Evamarie Hey‐Hawkins   +4 more
openaire   +3 more sources

Expression of the GFP-tagged ABCG2 variants in HUES9 cells.

, 2018
(A) Confocal images for HUES9 cell clumps expressing the GFP-ABCG2 variants (green), HUES9 cells are cultured on mouse embryonic fibroblasts. Immunostaining for Oct4 (red), cell nuclei are stained with DAPI (blue).
György Várady (120120), László Homolya (538824), Zsuzsa Erdei (5094704), Tamás I. Orbán (623373), Kornélia Szebényi (5094701), Balázs Sarkadi (120135), Ágota Apáti (5094698), Anita Schamberger (623372), György Török (4020647)   +8 more
core   +1 more source

E2F1 drives chemotherapeutic drug resistance via ABCG2 [PDF]

, 2014
Multidrug resistance is a major barrier against successful chemotherapy, and this has been shown in vitro to be often caused by ATP-binding cassette (ABC) transporters.
Dufès, C., Dufès, Christine, Bell, L.A., C Dufès, Ryan, K.M., Roberts, Fiona, L A Bell, O'Prey, Jim, J O'Prey, Long, Jaclyn, O'Prey, J, C Nixon, Roberts, F., Nixon, Colin, Nixon, C, Rosenfeldt, M.T., F Roberts, Bell, Laura, Rosenfeldt, MT, Ryan, KM, K M Ryan, O'Prey, J., Nixon, C., Bell, LA, Long, J.S., J S Long, Rosenfeldt, Mathias, M T Rosenfeldt, Long, JS, Roberts, F, Ryan, Kevin, Dufès, C   +31 more
core   +4 more sources

ФАРМАКОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ТЕРАПИИ ТРОМБОЗА УШКА ЛЕВОГО ПРЕДСЕРДИЯ: РЕЗИСТЕНТНОСТЬ К ЛЕЧЕНИЮ ПРЯМЫМИ ПЕРОРАЛЬНЫМИ АНТИКОАГУЛЯНТАМИ У ПАЦИЕНТОВ С ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta
Актуальность. Фибрилляция предсердий (ФП) является самым распространенным нарушением ритма сердца, которое ассоциировано с повышенным риском тромбоэмболических осложнений.
О. В. Будревич, В. А. Снежицкий   +1 more
doaj   +1 more source

Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma

Gastroenterology Research and Practice, 2013
Background. Despite improvement in treatment, the prognosis of hepatocellular carcinoma (HCC) remains disastrous. Cancer stem cells (CSCs) may be responsible for cancer malignant behaviors.
Guang Zhang, Zhongxia Wang, Weihuan Luo, Hongbo Jiao, Junhua Wu, Chunping Jiang   +5 more
doaj   +1 more source