Results 71 to 80 of about 26,096 (220)
Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles
Scientific Reports, 2021 The ATP-binding cassette transporter ABCG2 mediates the efflux of several chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in many cancers.
Diogo Henrique Kita +17 more
doaj +1 more source
Pharmaceuticals, 2023 The high expression of the ATP-binding cassette (ABC) drug transporter ABCG2 in cancer cells contributes to the emergence of multidrug resistance (MDR) in individuals afflicted with either solid tumors or blood cancers.
Chung-Pu Wu +7 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Abemaciclib increases serum creatinine by inhibiting renal tubular transporters rather than reducing true glomerular filtration rate, a phenomenon known as pseudo‐acute kidney injury. Creatinine–cystatin C discrepancy and genetic determinants of this elevation remain insufficiently characterized in Japanese patients.
Hiroaki Watanabe +5 more
wiley +1 more source
Molecular and cellular characterization of ABCG2 in the prostate [PDF]
BMC Urology, 2007 Identification and characterization of the prostate stem cell is important for understanding normal prostate development and carcinogenesis. The flow cytometry-based side population (SP) technique has been developed to isolate putative adult stem cells in several human tissue types including the prostate.
Pascal, Laura E. +6 more
openaire +4 more sources
Abcg2 transporter affects plasma, milk and tissue levels of meloxicam [PDF]
, 2023 https://doi.org/10.1016/j.bcp.2020.113924ATP-binding cassette (ABCG2) is an efflux transporter that extrudes xenotoxins from cells in liver, intestine, mammary gland, brain and other organs, affecting the pharmacokinetics, brain accumulation and ...
Blanco Paniagua, Esther +7 more
core
Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network
Clinical Pharmacology &Therapeutics, EarlyView.Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang +16 more
wiley +1 more source
Does ABCG2 Need a Heterodimer Partner? Expression and Functional Evaluation of ABCG2 (Arg 482)*
Drug Metabolism and Pharmacokinetics, 2002 Accumulating evidence suggests that several ATP-binding cassette (ABC) transporters mediate the elimination of anticancer drugs from cancer cells and thereby confer drug resistance. SN-38-selected PC-6/SN2-5H human lung carcinoma cells were shown to overexpress ABCG2 with the reduced intracellular accumulation of SN-38, the active metabolite of ...
YOSHIKAWA, Megumi +8 more
openaire +2 more sources
ABCG2 Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban
Drug Design, Development and Therapy, 2023 Hamin Kim,1,* Tae-Jin Song,2,* Jeong Yee,1 Dong-Hyeok Kim,3 Junbeom Park,4 Hye Sun Gwak1 1College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea; 2Department of Neurology, Seoul Hospital, Ewha ...
Kim H +5 more
doaj
Acta Pharmaceutica Sinica B, 2020 Overexpression of adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2) in cancer cells is known to cause multidrug resistance (MDR), which severely limits the clinical efficacy of chemotherapy.
Fanpu Zeng +7 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus. The placenta is also responsible for the uptake and/or exchange of xenobiotics, including medications, between the maternal and fetal bloodstreams. An estimated 40–80% of women take medications or drugs during pregnancy.
Eric M. Weaver +6 more
wiley +1 more source