Results 81 to 90 of about 26,096 (220)
Acta Veterinaria, 2018 The main problems that cause unresponsiveness to an anti-neoplastic drug are the overexpression of drug resistant and anti-apoptotic proteins in tumor cells.
Sirivisoot Sirintra +4 more
doaj +1 more source
Adriamycin Induced Chemoresistance of Human TNBC MDA-MB-468 Cells Through Stat3-cMyc Signal Pathway
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the chemoresistance of human triple-negative breast cancer(TNBC) MDA-MB-468 cells induced by adriamycin(ADM) and the underlying mechanism.
XU Jinyuan +7 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 The overexpression of ATP-binding cassette (ABC) transporters is one of the important mechanisms of multidrug resistance (MDR). Some tyrosine kinase inhibitors (TKIs) such as CM082 might be a potential ABC transporter inhibitor, thus potentially ...
Lejia Xu +9 more
doaj +1 more source
Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport
Pharmacological Research, 2017 Cancer is a disease whose treatment is often limited due to the development of a phenomenon known as multidrug resistance (MDR). There is an immense demand for development of novel agents that can overcome the MDR in cancer. A group of transmembrane proteins called ATP-binding cassette transporters, present ubiquitously in the human body possesses a ...
Atish, Patel +9 more
openaire +2 more sources
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
Medicinal Research Reviews, EarlyView.ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti +6 more
wiley +1 more source
Tumourigenesis of ABCG2hiSP and ABCG2lowNSP cells in nude mice at 30 days.
, 2012 Tumourigenesis of ABCG2hiSP and ABCG2lowNSP cells in nude mice at 30 days.
Rakesh Heer (114718) +9 more
core +1 more source
Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model
Photochemistry and Photobiology, EarlyView.Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore +6 more
wiley +1 more source
Inhibition of ABCG2 in MCF-7 the cell line: A litterature study of seven scientific articles [PDF]
, 2017 En af de store forhindringer indenfor behandlingen af brystkræft er kemoresistens. ATP-binding cassette transporter type G2 (ABCG2) er en eksporteringspumpe, der beskytter cellen ved at pumpe uønskede substrater ud, herunder kemopræparater.
Christiansen, Maja Østergaard +4 more
core
Photochemistry and Photobiology, EarlyView.Recent studies demonstrate that near‐infrared (NIR—750–980 nm)‐mediated photodynamic (PDT) and photothermal (PTT) therapies, combined with metallic nanoparticles (MNPs), show promising results against skin cancer, particularly melanoma, in both in vitro and in vivo models.
Tamyris Devincenzi +3 more
wiley +1 more source
Analysis of ABCG2 polymorphisms.
, 2013 Analysis of ABCG2 polymorphisms.
Caterina A. M. La Porta (187294) +10 more
core +1 more source