Results 61 to 70 of about 26,096 (220)

Bone marrow‐like viscosity affects imatinib resistance in chronic myeloid leukemia

Biotechnology Progress, EarlyView.
Physical cues such as microenvironmental viscosity have been recognized as important regulators in controlling cell functions. However, even though the bone marrow (BM) is a viscous tissue in which cells respond mechanically to both the matrix stiffness and the viscosity of surrounding fluid, the impact of microenvironmental viscosity on imatinib (IM ...
Tianjiao Zeng, Huajian Chen, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +6 more
wiley   +1 more source

Karanjin interferes with ABCB1, ABCC1, and ABCG2 [PDF]

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination. They also mediate multi-drug resistance in cancer cells.
Martin Michaelis, Florian Rothweiler, Thomas Nerreter, Mohsen Sharifi, Taravat Ghafourian, Jindrich Cinatl   +5 more
openaire   +4 more sources

Tumor xenografts derived from ABCG2+ and ABCG2- IGR39 cells.

, 2013
5×105 unsorted, ABCG2+ or ABCG2- sorted cells were injected subcutaneously in five-week-old NOD-SCID mice (3 mice for each experimental condition). After 60 days, the tumor mass was excised weighed and photographed.
Caterina A. M. La Porta (187294), Luca Sigalotti (38328), Minsoo Noh (213445), PierGiorgio Natali (358386), Rouzbeh Taghizadeh (358383), Yang Hoon Huh (213447), Michele Maio (264944), Emilio Ciusani (191588), James L. Sherley (213448), Maria R. Nicotra (358384), Beatrice Arosio (319697)   +10 more
core   +1 more source

A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance.

PLoS Biology, 2023
The eradication of cancer stem cells (CSCs) with drug resistance confers the probability of local tumor control after chemotherapy or targeted therapy. As the main drug resistance marker, ABCG2 is also critical for colorectal cancer (CRC) evolution, in ...
Jiaojiao Hao, Jinsheng Huang, Chunyu Hua, Yan Zuo, Wendan Yu, Xiaojun Wu, Liren Li, Guoqing Xue, Xinyu Wan, Liyuan Ru, Ziyue Guo, Shilong Han, Wuguo Deng, Fei Lin, Wei Guo   +14 more
doaj   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Expression and function of ABCG2 and XIAP in glioblastomas [PDF]

Journal of Neuro-Oncology, 2017
Despite multimodal treatment that includes surgery, radiation and chemotherapy, virtually all glioblastomas (GBM) recur, indicating that these interventions are insufficient to eradicate all malignant cells. To identify potential new therapeutic targets in GBMs, we examined the expression and function of proteins that are associated with therapy ...
Ivette F. Emery, Archana Gopalan, Stephanie Wood, Kin-hoe Chow, Chiara Battelli, Joshy George, Hagen Blaszyk, Jeffrey Florman, Kyuson Yun   +8 more
openaire   +3 more sources

Botryllamides: Natural Product Inhibitors of ABCG2

, 2016
ABCG2 is a membrane-localized, human transporter protein that has been demonstrated to reduce the intracellular accumulation of substrates through ATP-dependent efflux.
Kentaro Takada (1476262), Kirk R. Gustafson (131179), Suneet Shukla (401303), Suresh V. Ambudkar (223101), James B. McMahon (7677), Robert W. Robey (2354755), Susan E. Bates (2228851), Heidi R. Bokesch (131163), Curtis J. Henrich (131182)   +8 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Evaluation of the interaction between the pesticides chlorantraniliprole and imidacloprid with the ATP-binding cassette transporter G2 (ABCG2): In vitro and in vivo assays [PDF]

[EN] Pesticides used in agriculture to control pests can also affect non-target animals, such as livestock and humans, through exposure. Pesticide residues found in animal-derived products like milk serve as evidence of exposure in mammals and may pose ...
Blanco Paniagua, Esther, Merino Peláez, Gracia, Millán García, Alicia, Álvarez Fernández, Indira, Álvarez Fernández, Laura   +4 more
core   +1 more source

TEPOTINIB REVERSES ABCB1- AND ABCG2-MEDIATED MULTIDRUG RESISTANCE IN CANCER [PDF]

, 2022
Overexpression of ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells have been linked to the development of multidrug resistance (MDR), an obstacle to cancer therapy.
Wu, Zhuoxun
core