Results 61 to 70 of about 19,287 (163)

Estrogen induces cell proliferation by promoting ABCG2-mediated efflux in endometrial cancer cells

Biochemistry and Biophysics Reports, 2018
Recently, it has reported that overeating of lipid-food has led to increase the amount of estrogen in vivo and the incidence of endometrial carcinomas.
Takahiro Yaguchi, Takafumi Onishi
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PCI29732, a Bruton’s Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Multidrug resistance (MDR) induced by the ABC transporter subfamily B member 1 (ABCB1) and subfamilyG member 2 (ABCG2) limits successful cancer chemotherapy and no commercially available MDR modulator is used in the clinic.
Chunlei Ge, Fang Wang, Chaochu Cui, Xiaodong Su, Kenneth Kin Wah To, Xiaokun Wang, Hui Zhang, Xin Song, Liwu Fu   +8 more
doaj   +1 more source

Pharmacogenetic Aspects of the Interaction of AT1 Receptor Antagonists With ATP-Binding Cassette Transporter ABCG2

Frontiers in Pharmacology, 2018
The ATP-binding cassette transporter ABCG2 (BCRP and MXR) is involved in the absorption, distribution, and elimination of numerous drugs. Thus, drugs that are able to reduce the activity of ABCG2, e.g., antihypertensive AT1 receptor antagonists (ARBs ...
Anne Ripperger, Anna Krischer, Dina Robaa, Wolfgang Sippl, Ralf A. Benndorf   +4 more
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Expression of ABCG2 Associated with Tumor Response in Metastatic Colorectal Cancer Patients Receiving First-line FOLFOX Therapy – Preliminary Evidence

The International Journal of Biological Markers, 2013
Purpose We retrospectively analyzed ABCG2 expression levels in patients with metastatic colorectal cancer (CRC) to investigate the interaction between ABCG2 expression and the tumor response to oxaliplatin and 5-fluorouracil (FOLFOX). Methods Forty-three
Pei-Ching Lin, Hung-Hsin Lin, Jen-Kou Lin, Chun-Chi Lin, Shung-Haur Yang, Anna Fen-Yau Li, Wei-Shone Chen, Shih-Ching Chang   +7 more
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Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)

Frontiers in Pharmacology
IntroductionMultidrug resistance (MDR) in cancer therapy, frequently driven by overexpression of ATP-binding cassette (ABC) transporters—particularly ABCG2—continues to undermine the efficacy of chemotherapeutic regimens.
Haigan Yang, Haigan Yang, Zheshen Li, Zhuoxun Wu, Xiang Chen, Letao Bo, Harsh Patel, Bohan Zhang, Wenjun Xiong, Wei Wang, Zhe-Sheng Chen   +10 more
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Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

Oncotarget, 2014
ABCG2 is a potential biomarker causing multidrug resistance (MDR) in Non-Small Cell Lung Cancer (NSCLC). We conducted this study to investigate whether Icotinib, a small-molecule inhibitor of EGFR tyrosine kinase, could interact with ABCG2 transporter in NSCLC. Our results showed that Icotinib reversed ABCG2-mediated MDR by antagonizing the drug efflux
De-Shen, Wang, Atish, Patel, Suneet, Shukla, Yun-Kai, Zhang, Yi-Jun, Wang, Rishil J, Kathawala, Robert W, Robey, Li, Zhang, Dong-Hua, Yang, Tanaji T, Talele, Susan E, Bates, Suresh V, Ambudkar, Rui-Hua, Xu, Zhe-Sheng, Chen   +13 more
openaire   +3 more sources

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

Frontiers in Pharmacology, 2018
The main characteristic of tumor cell resistance is multidrug resistance (MDR). MDR is the principle cause of the decline in clinical efficacy of chemotherapeutic drugs. There are several mechanisms that could cause MDR.
Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Chao-Yun Cai, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Leli Zeng, Leli Zeng, Pranav Gupta, Zhe-Sheng Chen   +11 more
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Dorsomorphin attenuates ABCG2-mediated multidrug resistance in colorectal cancer

Frontiers in Pharmacology
Colorectal cancer is a common malignant tumor with high mortality, for which chemotherapy resistance is one of the main reasons. The high expression of ABCG2 in the cancer cells and expulsion of anticancer drugs directly cause multidrug resistance (MDR).
Xiao-Peng Li, Xiao-Peng Li, Liang-Qi Cao, Ze-Zhong Yu, Ze-Zhong Yu, Ke He, Peng-Bo Ding, Ji-Sheng Li, Yi-Yao Shan, Yu-Bin Su, Zhong-Min Yuan, Zhi Shi, Zhi Shi   +12 more
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Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2018
Background ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intracellular ...
Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan, Liwu Fu   +8 more
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Reversal of ABCG2-mediated MDR by VEGFR3 inhibitor (S)-SAR131675

Frontiers in Pharmacology
Multidrug resistance (MDR) remains a major challenge in cancer treatment, as it is a significant factor contributing to chemotherapy failure and cancer recurrence.
Xiang Chen, Jiaqian Xu, Ryan Li, Ryan Li, Xing-Duo Dong, Yi-Dong Li, Qiu-Xu Teng, Ziqi Wang, Ziqi Wang, Zhe-Sheng Chen   +9 more
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