Results 41 to 50 of about 19,287 (163)
Molecular and cellular characterization of ABCG2 in the prostate [PDF]
BMC Urology, 2007 Identification and characterization of the prostate stem cell is important for understanding normal prostate development and carcinogenesis. The flow cytometry-based side population (SP) technique has been developed to isolate putative adult stem cells in several human tissue types including the prostate.
Pascal, Laura E. +6 more
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Reevaluation of the Roles of ABCG2 in the Disposition of Genistein [PDF]
Drug Metabolism and Disposition, 2012 The purpose of this letter is to clarify some assessments in the article by [Yang et al. (2012)][1], in which they questioned the credibility of a conclusion in our recently published article ([Alvarez et al., 2011][2]). [Yang et al.
Ana I, Alvarez +6 more
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BMC Cancer, 2017 Background ATP-binding cassette sub-family G member 2 (ABCG2) is a semi-transport protein that plays a major role in multidrug resistance. We aimed to evaluate the prognostic significance of ABCG2 expression in patients with clear cell renal cell ...
Haofei Wang +9 more
doaj +1 more source
Structure of the human multidrug transporter ABCG2 [PDF]
Nature, 2017 ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the pharmacokinetics of commonly used drugs and limits the delivery of therapeutics into tumour cells, thus contributing to multidrug resistance. Here we present the structure of human ABCG2 determined
Taylor, Nicholas M. I. . +5 more
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Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles
Scientific Reports, 2021 The ATP-binding cassette transporter ABCG2 mediates the efflux of several chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in many cancers.
Diogo Henrique Kita +17 more
doaj +1 more source
Pharmaceuticals, 2023 The high expression of the ATP-binding cassette (ABC) drug transporter ABCG2 in cancer cells contributes to the emergence of multidrug resistance (MDR) in individuals afflicted with either solid tumors or blood cancers.
Chung-Pu Wu +7 more
doaj +1 more source
Does ABCG2 Need a Heterodimer Partner? Expression and Functional Evaluation of ABCG2 (Arg 482)*
Drug Metabolism and Pharmacokinetics, 2002 Accumulating evidence suggests that several ATP-binding cassette (ABC) transporters mediate the elimination of anticancer drugs from cancer cells and thereby confer drug resistance. SN-38-selected PC-6/SN2-5H human lung carcinoma cells were shown to overexpress ABCG2 with the reduced intracellular accumulation of SN-38, the active metabolite of ...
YOSHIKAWA, Megumi +8 more
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Frontiers in Pharmacology, 2013 ABCG2 is a key human ATP-Binding Cassette (ABC) transporter mediating cancer cell chemoresistance. In the case of ABCC1, another multidrug transporter, earlier findings documented that certain modulators greatly increase ABCC1-mediated GSH efflux and ...
Charlotte eGauthier +4 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 The overexpression of ATP-binding cassette (ABC) transporters is one of the important mechanisms of multidrug resistance (MDR). Some tyrosine kinase inhibitors (TKIs) such as CM082 might be a potential ABC transporter inhibitor, thus potentially ...
Lejia Xu +9 more
doaj +1 more source
Karanjin interferes with ABCB1, ABCC1, and ABCG2 [PDF]
Journal of Pharmacy & Pharmaceutical Sciences, 2014 PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination. They also mediate multi-drug resistance in cancer cells.
Martin Michaelis +5 more
openaire +4 more sources