ABCG2 Overexpression Contributes to Pevonedistat Resistance [PDF]
Cancers, 2020 MLN4924 (pevonedistat) is a first-in-class NEDD8-activating enzyme (NAE) inhibitor in clinical trials for the treatment of solid tumors and hematologic malignancies. Despite the promising activity of MLN4924 observed in early trials, drug resistance has been noted in some patients.
Rishil J. Kathawala +8 more
openaire +2 more sources
Y6, an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance [PDF]
, 2019 Multidrug resistance is reported to be related to the transmembrane transportation of chemotherapeutic drugs by adenosine triphosphate-binding cassette (ABC) transporters.
Pranav Gupta +8 more
core +1 more source
Botryllamides: Natural Product Inhibitors of ABCG2 [PDF]
ACS Chemical Biology, 2009 ABCG2 is a membrane-localized, human transporter protein that has been demonstrated to reduce the intracellular accumulation of substrates through ATP-dependent efflux. Highly expressed in placental syncytiotrophoblasts, brain microvasculature, and the gastrointestinal tract, ABCG2 has been shown to mediate normal tissue protection as well as limit ...
Curtis J, Henrich +8 more
openaire +2 more sources
Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro. [PDF]
, 2011 The success of Imatinib (IM) therapy in chronic myeloid leukemia (CML) is compromised by the development of IM resistance and by a limited IM effect on hematopoietic stem cells.
Carsten Bokemeyer +40 more
core +2 more sources
Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter [PDF]
, 2022 Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO2) and albendazole 2-aminosulphone (
Blanco Paniagua, Esther +14 more
core +1 more source
ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing
, 2017 The ATP-binding cassette transporter ABCG2 is expressed in the interfollicular epidermis and mediates the side-population phenotype in skin cells. However, the role of ABCG2 in skin is unclear. Increased expression levels of ABCG2 were found at the basal
林頌然 +1 more
core +1 more source
Multidrug efflux transporter ABCG2: expression and regulation
, 2021 The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was originally discovered in a multidrug-resistant breast cancer cell line.
Guin, Debleena +23 more
core +1 more source
Frontiers in Pharmacology, 2013 ABCG2 is a key human ATP-Binding Cassette (ABC) transporter mediating cancer cell chemoresistance. In the case of ABCC1, another multidrug transporter, earlier findings documented that certain modulators greatly increase ABCC1-mediated GSH efflux and ...
Charlotte eGauthier +4 more
doaj +1 more source
Reevaluation of the Roles of ABCG2 in the Disposition of Genistein [PDF]
Drug Metabolism and Disposition, 2012 The purpose of this letter is to clarify some assessments in the article by [Yang et al. (2012)][1], in which they questioned the credibility of a conclusion in our recently published article ([Alvarez et al., 2011][2]). [Yang et al.
Ana I, Alvarez +6 more
openaire +2 more sources
ABCG2 bimolecular fluorescence complementation is specific.
, 2013 HEK293T cells were transfected with constructs expressing either eYFP-ABCG2 (as a positive fluorescence control, A), complementing halves of vYFP tagged to ABCG2 (B) or with vYN-ABCG2 and a non-specific interaction partner β2 adrenergic receptor (β2AR ...
Nicholas D. Holliday (342787) +5 more
core +1 more source