Results 31 to 40 of about 29,397 (197)

Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Frontiers in Oncology, 2020
ABCB1 overexpression is known to contribute to multidrug resistance (MDR) in cancers. Therefore, it is critical to find effective drugs to target ABCB1 and overcome MDR.
Weiguo Feng, Weiguo Feng, Meng Zhang, Meng Zhang, Zhuo-Xun Wu, Jing-Quan Wang, Xing-Duo Dong, Yuqi Yang, Qiu-Xu Teng, Xuan-Yu Chen, Xuan-Yu Chen, Qingbin Cui, Dong-Hua Yang   +12 more
doaj   +1 more source

Effect of ABCB1 3435C>T transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults

Asian Pacific Journal of Tropical Medicine, 2020
Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C>T (rs1045642) in the gene encoding ABCB1 was genotyped using
Sahapat Barusrux, Napatrupron Koomdee, Rattanaporn Sukprasong, Weerawat Manosuthi, Monpat Chamnanphon, Apichaya Puangpetch, Chonlaphat Sukasem, Veeranoot Nissapatorn, Maria de Lourdes Pereira   +8 more
doaj   +1 more source

Interpretation of results obtained using real-time fluorescence PCR based on multiplex PCR fragment analysis for ABCB1 tri-allele

Sichuan jingshen weisheng, 2022
ObjectiveTo resolve the problems related to the abnormal interpretations of real-time fluorescence polymerase chain reaction （PCR） results for tri-allele， to formulate the interpretation methods of real-time fluorescence PCR by referring to multiplex PCR
Zhang Yan, Meng Zhuocheng, Xing Huan, Cui Xiaohua, Yang Liu, Zheng Xuan, Dai Zunxiao   +6 more
doaj   +1 more source

Abcb1 Gene Polymorphisms Are Associated with the Severity of Major Depressive Disorder and Its Response to Escitalopram Treatment

, 2012
Objective ATP-binding cassette, sub-family B MDR/TAP, member 1 ABCB1 is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier.
LIN, KEH-MING;CHIU, YEN-FENG;SHEN, WINSTON W.;LIU, SHU CHIH;LU, SHAO-CHUN;LIU, CHIA-YIH;HSIAO, MEI-CHUN;TANG, HWA-SHENG;LIU, SHEN-ING;WU, CHI-SHIN;TSOU, HSIAO-HUI;TSAI, MING-HSIEN;KUO, HSIANG-WEI;LIU, YU-LI, 林克明;邱燕楓;沈武典;劉淑芝;呂紹俊;劉嘉逸;蕭美君;湯華盛;劉珣瑛;吳其炘;鄒小蕙;蔡銘賢;郭湘維   +1 more
core   +1 more source

人類abcb1基因多型性之功能及對抗癲癇藥治療效果之研究

, 2011
Objective The ABCB1 haplotype combinations have been demonstrated to be associated with epilepsy treatment outcomes. The aim of this study is to investigate whether ABCB1 haplotype combinations would affect P- glycoprotein ( Pgp) function and impact the ...
洪靚娟;陳至全;林君榮;劉宏輝, HUNG, CHIN-CHUAN;CHEN, CHIH-CHUAN;LIN, CHUN-JUNG;LIOU, HORNG-HUEI   +1 more
core   +1 more source

Safety of dabigatran in patients with atrial fibrillation and chronic kidney disease: pharmacokinetic and pharmacogenetic aspects

Медицинский совет, 2020
Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka, P. O. Bochkov, K. A. Akmalova, R. V. Shevchenko, P. M. Krupenin, V. V. Kogay, A. I. Listratov, A. S. Krainyaya, D. A. Napalkov, O. S. Gurinovich, A. A. Sokolova, V. V. Fomin, D. A. Sychev   +12 more
doaj   +1 more source

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)-0

, 2011
Copyright information:Taken from "Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)"http://www.tbiomed.com/content/4/1/33Theoretical Biology & Medical Modelling 2007;4 ...
Aina W Ravna (84483), Georg Sager (46955), Ingebrigt Sylte (84484)   +2 more
core   +1 more source

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)-1

, 2011
Copyright information:Taken from "Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)"http://www.tbiomed.com/content/4/1/33Theoretical Biology & Medical Modelling 2007;4 ...
Aina W Ravna (84483), Georg Sager (46955), Ingebrigt Sylte (84484)   +2 more
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source