Results 31 to 40 of about 26,813 (237)
ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1
Frontiers in Bioscience-Landmark, 2022 Background: One of the major concerns of cancer therapy is the emergence of multidrug resistance (MDR). The MDR-associated ATP-binding cassette sub-family B member 1 (ABCB1) transporter is established to mediate resistance against numerous anticancer ...
Zhuoxun Wu +9 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Pharmacogenomics and Personalized Medicine, 2021 Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y +9 more
doaj
Frontiers in Cell and Developmental Biology, 2020 Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ...
Xing-Duo Dong +11 more
doaj +1 more source
Use of photoimmunoconjugates to characterize ABCB1 in cancer cells
Nanophotonics, 2021 Abstract Accurate detection of ATP‐binding cassette drug transporter ABCB1 expression is imperative for precise identification of drug‐resistant tumors. Existing detection methods fail to provide the necessary molecular details regarding the functional state of the transporter.
Barry J. Liang +3 more
openaire +4 more sources
Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia
Pharmaceutical Biology, 2018 Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia.
Javad Mottaghipisheh +5 more
doaj +1 more source
Validation of a simple genotyping panel assay for pharmacogenomics of taxane-based therapy: preliminary results [PDF]
World Cancer Research Journal, 2023 Objective: Several strategies for preventing toxicity and resistance to taxane-based chemotherapy have been investigated so far. Lately, findings on the genetic variants associated with neutropenia and neuropathy (N&N) toxicity have been reported ...
A. Vitale +9 more
doaj +1 more source
Sichuan jingshen weisheng, 2022 ObjectiveTo resolve the problems related to the abnormal interpretations of real-time fluorescence polymerase chain reaction （PCR） results for tri-allele， to formulate the interpretation methods of real-time fluorescence PCR by referring to multiplex PCR
Zhang Yan +6 more
doaj +1 more source
Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity [PDF]
Pharmaceutics, 2021 P-glycoprotein (Pgp, ABCB1) is a member of one of the largest families of active transporter proteins called ABC transporters. Thanks to its expression in tissues with barrier functions and its broad substrate spectrum, it is an important determinant of the absorption, metabolism and excretion of many drugs.
Kuljeet Singh +7 more
openaire +3 more sources
The ABCB1 Transporter in Alzheimer’s Disease [PDF]
Clinical & Experimental Pharmacology, 2014 ABC genes, especially ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1; Doxorubicin resistance; Multidrug resistance 1; Multidrug resistance protein 1; P-glycoprotein 1; P glycoprotein 1/ multiple drug resistance 1;P-gp) (7q21.12), ABCC1 (9q31.1), ABCG2 (White1) (21q22.3), and other genes of this family encode proteins which are essential ...
López-Muñoz, F., Cacabelos, Ramón
openaire +2 more sources