Results 11 to 20 of about 285,749 (186)

Thermodynamics of ABC transporters [PDF]

Protein & Cell, 2015
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and
Xuejun C. Zhang, Lei Han, Yan Zhao
doaj   +5 more sources

ABC transporters: the power to change [PDF]

Nature Reviews Molecular Cell Biology, 2009
ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of many substrates across membranes. The highly conserved ABC domains of ABC transporters provide the nucleotide-dependent engine that drives transport.
Eric Johnson, Douglas C. Rees, Oded Lewinson   +2 more
exaly   +6 more sources

Peroxisomal ABC transporters [PDF]

FEBS Letters, 2006
Peroxisomes perform a range of different functions, dependent upon organism, tissue type, developmental stage or environmental conditions, many of which are connected with lipid metabolism. This review summarises recent research on ATP binding cassette (ABC) transporters of the peroxisomal membrane (ABC subfamily D) and their roles in plants, fungi and
Theodoulou, F. L., Holdsworth, M., Baker, A.   +2 more
openaire   +4 more sources

Clinical Significance of Lipid Transport Function of ABC Transporters in the Innate Immune System

Membranes, 2022
ABC transporters are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes.
Anna Kotlyarova, Stanislav Kotlyarov
exaly   +3 more sources

Plant ABC transporters [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2000
The ATP binding cassette (ABC) superfamily is a large, ubiquitous and diverse group of proteins, most of which mediate transport across biological membranes. ABC transporters have been shown to function not only as ATP-dependent pumps, but also as ion channels and channel regulators.
Theodoulou, Frederica L., Theodoulou, F. L.   +1 more
openaire   +3 more sources

Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma [PDF]

Pharmaceuticals
Background: The multiple drug-resistant phenomenon has long since plagued the effectiveness of various chemotherapies used in the treatment of patients with glioblastoma (GBM), which is still incurable to this day. ATP-binding cassette (ABC) transporters
Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin   +5 more
doaj   +2 more sources

Plant ABC Transporters [PDF]

The Arabidopsis Book, 2011
ABC transporters constitute one of the largest protein families found in all living organisms. ABC transporters are driven by ATP hydrolysis and can act as exporters as well as importers. The plant genome encodes for more than 100 ABC transporters, largely exceeding that of other organisms.
Joohyun Kang, Jiyoung Park, Hyunju Choi, Bo Burla, Tobias Kretzschmar, Youngsook Lee, Enrico Martinoia   +6 more
openaire   +5 more sources

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters [PDF]

Nature Communications
SbmA is a membrane transporter from Escherichia coli that imports antimicrobial peptides. SbmA belongs to the SbmA-like peptide transporter (SLiPT) family.
Thijs W. Ettema, Satomi Inaba-Inoue, Chancievan Thangaratnarajah, Leticia Alves da Silva, Nikas Senning, Amy Clarke, Piotr Stepien, Anokhi Shah, Yue Ma, Katie Hardman, Sophia David, Hassane El Mkami, Jonathan G. Heddle, Norimichi Nomura, Satoshi Ogasawara, So Iwata, Dmitry Ghilarov, Christos Pliotas, Thomas Stockner, Dirk J. Slotboom, Konstantinos Beis   +20 more
doaj   +3 more sources

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs [PDF]

Frontiers in Pharmacology
ATP-binding cassette (ABC) transporters are transmembrane proteins expressed commonly in metabolic and excretory organs to control xenobiotic or endobiotic disposition and maintain their homeostasis.
Yimei Wang, Mei-Juan Tu, Ai-Ming Yu
doaj   +2 more sources

ABC Transporters [PDF]

FEBS Letters, 2006
ABC transporters are proteins that are involved in the uptake of nutrients and excretion of harmful substances in biological cells. Defects in human ABC transporters can result in severe diseases. Too high ABC transporter activity can lead to non-responsiveness of cancercells to chemotherapy, and resistance of bacteria to antibiotics.
Flügge, U.I., van Meer, G.
  +8 more sources