Toward Determining ATPase Mechanism in ABC Transporters: Development of the Reaction Path–Force Matching QM/MM Method [PDF]
, 2016 Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are ubiquitous ATP-dependent membrane proteins involved in translocations of a wide variety of substrates across cellular membranes.
Arantes +86 more
core +1 more source
Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems [PDF]
, 2015 The ABC (ATP-binding cassette) transporter family in higher plants is highly expanded compared with those of mammalians. Moreover, some members of the plant ABCB subfamily display very high substrate specificity compared with their mammalian ...
Aryal, Bibek +2 more
core +1 more source
The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids [PDF]
, 2012 ATP-binding cassette (ABC) transporters are highly expressed by brain endothelial cells that form the blood-brain barrier (BBB). These efflux pumps play an important role in maintaining brain homeostasis as they actively hinder the entry of unwanted ...
Bandaru, V.V.R. +4 more
core +3 more sources
BMC Genomics, 2017 Background ABC transporter superfamily is one of the largest and ubiquitous groups of proteins. Because of their role in detoxification, insect ABC transporters have gained more attention in recent years. In this study, we annotated ABC transporters from
Lixia Tian +8 more
doaj +1 more source
The ABCC6 transporter : what lessons can be learnt from other ATP-binding cassette transporters? [PDF]
, 2013 ABC transporters represent a large family of ATP-driven transmembrane transporters involved in uni- or bidirectional transfer of a large variety of substrates.
De Paepe, Anne +2 more
core +2 more sources
Peroxisomal ABC Transporters: An Update [PDF]
International Journal of Molecular Sciences, 2021 ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of conserved proteins from bacteria to mammals. In humans, three members of this family are expressed in the peroxisomal membrane and belong to the subfamily D: ABCD1 (ALDP), ABCD2 (ALDRP), and ABCD3 (PMP70).
Tawbeh, Ali +3 more
openaire +2 more sources
Analysis of ABC Transporter Gene Expression in Atherosclerosis
Cardiogenetics, 2021 ABC transporters are a large family of membrane proteins that transport chemically diverse substrates across the cell membrane. Disruption of transport mechanisms mediated by ABC transporters causes the development of various diseases, including ...
Stanislav Kotlyarov, Anna Kotlyarova
doaj +1 more source
A distinct mechanism for the ABC transporter BtuCD–BtuF revealed by the dynamics of complex formation [PDF]
, 2010 ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a diverse array of substrates across cell membranes. We present here the dynamics of complex formation of three structurally characterized ABC transporters—the BtuCD ...
Lee, Allen T. +3 more
core +2 more sources
A-subclass ATP-binding cassette proteins in brain lipid homeostasis and neurodegeneration
Frontiers in Psychiatry, 2012 The A-subclass of ATP-binding cassette (ABC) transporters comprises twelve structurally related members of the evolutionarily highly conserved superfamily of ABC transporters.
Armin P. Piehler +3 more
doaj +1 more source
A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae [PDF]
, 2013 Background: The ABC (ATP-binding cassette) gene superfamily is widespread across all living species. The majority of ABC genes encode ABC transporters, which are membrane-spanning proteins capable of transferring substrates across biological membranes by
Edward Osborne +5 more
core +4 more sources