Results 51 to 60 of about 60,654 (250)
Human ATP-binding cassette (ABC) transporter family
Human Genomics, 2009 There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps.
Vasiliou Vasilis +2 more
doaj +1 more source
Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Nature Communications, 2021 Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes ...
Emily L. Giddings +24 more
doaj +1 more source
From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates
Advanced Materials, EarlyView.Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot +3 more
wiley +1 more source
PLoS ONE, 2015 Salmon lice, Lepeophtheirus salmonis (Krøyer, 1837), are fish ectoparasites causing significant economic damage in the mariculture of Atlantic salmon, Salmo salar Linnaeus, 1758. The control of L.
Greta Carmona-Antoñanzas +7 more
doaj +1 more source
Karanjin interferes with ABCB1, ABCC1, and ABCG2
Journal of Pharmacy & Pharmaceutical Sciences, 2014 PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination.
Martin Michaelis +5 more
doaj +1 more source
Gout, genetics and ABC transporters [PDF]
F1000 Biology Reports, 2011 Gout is a chronic arthritic disease associated with high levels of urate in blood. Recent advances in research have permitted the identification of several new and common genetic factors underlying the disease. Among them, a polymorphism in the ABC transporter gene ATP-binding cassette transporter isoform G2 has been highlighted.
Basseville, Agnès, Bates, Susan E.
openaire +2 more sources
Advanced Materials, EarlyView.Alkoxy chain length drives a continuous transition from eclipsed AA to a serrated, slipped AA* configuration over Co‐porphyrin COFs. A moderate slip both contracts the pore channel to enrich CO2 and suppress hydrogen evolution, and enhances collective high‐spin of Co sites, which delivers a record CO production rate with high selectivity.
Jie He +8 more
wiley +1 more source
Comparative and functional genomics of the ABC transporter superfamily across arthropods
BMC Genomics, 2021 Background The ATP-binding cassette (ABC) transporter superfamily is comprised predominantly of proteins which directly utilize energy from ATP to move molecules across the plasma membrane.
Shane Denecke +8 more
doaj +1 more source
Phase Diagrams Enable Solid‐State Battery Design
Advanced Materials Interfaces, EarlyView.Batteries are non‐equilibrium devices with inherent thermodynamic driving forces to react at interfaces, regardless of kinetics or operating conditions. Chemical potential mismatches across interfaces are dissipated via interfacial reactions. In this work, it is illustrated how phase diagrams and chemical potential maps predict degradation pathways but
Nathaniel L. Skeele, Matthias T. Agne
wiley +1 more source
Parasites & Vectors, 2014 Background Proteins from the ABC family (ATP-binding cassette) represent the largest known group of efflux pumps, responsible for transporting specific molecules across lipid membranes in both prokaryotic and eukaryotic organisms. In arthropods they have
Sara Epis +11 more
doaj +1 more source