Results 71 to 80 of about 285,749 (186)

Karanjin interferes with ABCB1, ABCC1, and ABCG2

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination.
Martin Michaelis, Florian Rothweiler, Thomas Nerreter, Mohsen Sharifi, Taravat Ghafourian, Jindrich Cinatl   +5 more
doaj   +1 more source

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Nature Communications, 2021
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes ...
Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon   +24 more
doaj   +1 more source

A Survey of the ATP-Binding Cassette (ABC) Gene Superfamily in the Salmon Louse (Lepeophtheirus salmonis).

PLoS ONE, 2015
Salmon lice, Lepeophtheirus salmonis (Krøyer, 1837), are fish ectoparasites causing significant economic damage in the mariculture of Atlantic salmon, Salmo salar Linnaeus, 1758. The control of L.
Greta Carmona-Antoñanzas, Stephen N Carmichael, Jan Heumann, John B Taggart, Karim Gharbi, James E Bron, Michaël Bekaert, Armin Sturm   +7 more
doaj   +1 more source

Comparative and functional genomics of the ABC transporter superfamily across arthropods

BMC Genomics, 2021
Background The ATP-binding cassette (ABC) transporter superfamily is comprised predominantly of proteins which directly utilize energy from ATP to move molecules across the plasma membrane.
Shane Denecke, Ivan Rankić, Olympia Driva, Megha Kalsi, Ngoc Bao Hang Luong, Benjamin Buer, Ralf Nauen, Sven Geibel, John Vontas   +8 more
doaj   +1 more source

ABC transporters are involved in defense against permethrin insecticide in the malaria vector Anopheles stephensi

Parasites & Vectors, 2014
Background Proteins from the ABC family (ATP-binding cassette) represent the largest known group of efflux pumps, responsible for transporting specific molecules across lipid membranes in both prokaryotic and eukaryotic organisms. In arthropods they have
Sara Epis, Daniele Porretta, Valentina Mastrantonio, Francesco Comandatore, Davide Sassera, Paolo Rossi, Claudia Cafarchia, Domenico Otranto, Guido Favia, Claudio Genchi, Claudio Bandi, Sandra Urbanelli   +11 more
doaj   +1 more source

Plant peroxisomal ABC transporters: flexible and unusual

, 2014
ABC transporters of subfamily D mediate import of substrates for β-oxidation into peroxisomes. Whilst mammals possess three peroxisomal ABCD proteins which homodimerise to form transporters with distinct substrate specificities, Baker’s yeast has a ...
Baldwin, J. M., Theodoulou, F. L., Alison Baker, Baldwin, S. A., Frederica L. Theodoulou, Stephen A. Baldwin, Jocelyn M. Baldwin, Baker, A.   +7 more
core   +1 more source

Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System

Cells
ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of substrates across different cellular membranes. In the central nervous system (CNS), ABC transporters have recently gathered significant attention due to their ...
Maria Villa, Jingyun Wu, Stefanie Hansen, Jens Pahnke   +3 more
doaj   +1 more source

Filling the Gap: Functional Clustering of ABC Proteins for the Investigation of Hormonal Transport in planta

Frontiers in Plant Science, 2019
Plant hormones regulate a myriad of plant processes, from seed germination to reproduction, from complex organ development to microelement uptake. Much has been discovered on the factors regulating the activity of phytohormones, yet there are gaps in ...
Lorenzo Borghi, Joohyun Kang, Rita de Brito Francisco   +2 more
doaj   +1 more source

Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection

BMC Immunology, 2020
Background Understanding pathogenic mechanisms is imperative for developing novel treatment to the tuberculosis, an important public health burden worldwide.
Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang   +5 more
doaj   +1 more source

Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance

, 2011
Peroxisomes are indispensable organelles in higher eukaryotes. They are essential for a number of important metabolic pathways, including fatty acid α- and β-oxidation, and biosynthesis of etherphospholipids and bile acids.
Kemp, S., Theodoulou, Frederica L., Stephan Kemp, Wanders, Ronald J. A., Theodoulou, F. L., Kemp, Stephan, Frederica L Theodoulou, Ronald JA Wanders, Wanders, R. J. A.   +8 more
core   +1 more source