Results 121 to 130 of about 156,745 (364)
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia +4 more
wiley +1 more source
A highly granular SiPM-on-tile calorimeter prototype [PDF]
, 2018 The Analogue Hadron Calorimeter (AHCAL) developed by the CALICE collaboration is a scalable engineering prototype for a Linear Collider detector. It is a sampling calorimeter of steel absorber plates and plastic scintillator tiles read out by silicon photomultipliers (SiPMs) as active material (SiPM-on-tile). The front-end chips are integrated into the
arxiv +1 more source
Plant hormone transporters: what we know and what we would like to know [PDF]
, 2017 Hormone transporters are crucial for plant hormone action, which is underlined by severe developmental and physiological impacts caused by their loss-of-function mutations.
Geisler, Markus +3 more
core +4 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT Komagataella phaffii, also known as Pichia pastoris, is a powerful host for recombinant protein production, in part due to its exceptionally strong and tightly controlled PAOX1 promoter. Most K. phaffii bioprocesses for recombinant protein production rely on PAOX1 to achieve dynamic control in two‐phase processes.
Shannon M. Hoffman +4 more
wiley +1 more source
Harlequin Ichthyosis: Case Report
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2019 Harlequin ichthyosis is a rare autosomal recessive congenital disease in which neonates present generalized hyperkeratotic plaques and deep fissures, ectropion, eclabium, malformation of the auricular pavilion and typical facies.
Patrícia A. Couto +9 more
doaj +1 more source
CFTR Gating II: Effects of Nucleotide Binding on the Stability of Open States [PDF]
, 2005 Previously, we demonstrated that ADP inhibits cystic fibrosis transmembrane conductance regulator (CFTR) opening by competing with ATP for a binding site presumably in the COOH-terminal nucleotide binding domain (NBD2).
Bompadre, Silvia G. +6 more
core +2 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT There is increasing interest in the development of intensified processes that can provide significant reductions in manufacturing costs for monoclonal antibody (mAb) products. This study examines the performance of an integrated membrane process that combines single‐pass tangential flow filtration (SPTFF) with high‐performance countercurrent ...
Mirko Minervini +4 more
wiley +1 more source
The Alternative Choice of Constitutive Exons throughout Evolution [PDF]
PLoS Genet 2007 3(11): e203, 2008 Alternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution. We compiled a dataset of orthologous exons from human and mouse that are constitutively spliced in
arxiv
Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]
, 2019 We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey +2 more
core +1 more source
A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large‐scale production for clinical applications challenging. We have established a synthetic biology‐based platform to construct stable production cell lines, which ...
Yu‐Chieh Lin +5 more
wiley +1 more source