Results 191 to 200 of about 156,745 (364)

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Molecular Nutrition &Food Research, EarlyView.
Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García, Begoña Ayuda‐Durán, Susana González‐Manzano, Celestino Santos‐Buelga, Ana M. González‐Paramás   +4 more
wiley   +1 more source

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. [PDF]

Clin Pharmacol Ther, 2022
Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X.   +9 more
europepmc   +1 more source

Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family.

, 1994
Kathleen Fearon, V. McClendon, Bruno Bonetti, David M. Bedwell   +3 more
openalex   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model. [PDF]

Cancer Drug Resist, 2021
Hotz JM, Thomas JR, Katz EN, Robey RW, Horibata S, Gottesman MM.   +5 more
europepmc   +1 more source

Role of ATP-Binding-Cassette Transporter Genes in High-Frequency Acquisition of Resistance to Azole Antifungals in Candida glabrata [PDF]

, 2001
Dominique Sanglard, Françoise Ischer, Jacques Billé   +2 more
openalex   +1 more source

Trikafta Rescues F508del‐CFTR by Tightening Specific Phosphorylation‐Dependent Interdomain Interactions

Natural Sciences, EarlyView.
The most common cystic fibrosis mutation, F508del, destabilizes the first of two nucleotide‐binding domains (NBD1 and NBD2) and compromises Mg/ATP‐dependent gating at the interface between two transmembrane domains (TMD1 and TMD2) in the human cystic fibrosis transmembrane conductance regulator (CFTR).
Guangyu Wang
wiley   +1 more source

A Plant Plasma Membrane ATP Binding Cassette-Type Transporter Is Involved in Antifungal Terpenoid Secretion [PDF]

, 2001
Michał Jasiński, Yvan Stukkens, Herve Degand, Bénédicte Purnelle, Jacqueline Marchand‐Brynaert, Marc Boutry   +5 more
openalex   +1 more source

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

PROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An, Dries S. Martens, Gontse G. Mokwatsi, Yu‐Ling Yu, Babangida S. Chori, Agnieszka Latosinska, Godsent Isiguzo, Susanne Eder, Dong‐Yan Zhang, Gert Mayer, Ruan Kruger, Jana Brguljan‐Hitij, Christian Delles, Catharina M. C. Mels, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Peter Verhamme, Aletta E. Schutte, Tim S. Nawrot, Yan Li, Harald Mischak, Augustine N. Odili, Jan A. Staessen   +22 more
wiley   +1 more source

Molecular surveillance of resistance mutations in invasive populations of Spodoptera frugiperda in Europe, for evidence‐based pest control

Pest Management Science, EarlyView.
All Spodoptera frugiperda were rice strain with two haplotypes, likely from a common mixed source. ABCC2 and Ace‐1 mutations, conferring resistance to Bacillus thuringiensis and organophosphates/carbamates, respectively, were detected. Abstract BACKGROUND The invasive fall armyworm (Spodoptera frugiperda, FAW), a highly destructive pest affecting more ...
Konstantinos Mavridis, Vasiliki Evangelou, Alexandra M Grigoriadou, Dimitrios P Papachristos, John Vontas   +4 more
wiley   +1 more source