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ATP-Binding Cassette Transporters in Bacteria
Annual Review of Biochemistry, 2004▪ Abstract ATP-binding cassette (ABC) transporters couple ATP hydrolysis to the uptake and efflux of solutes across the cell membrane in bacteria and eukaryotic cells. In bacteria, these transporters are important virulence factors because they play roles in nutrient uptake and in secretion of toxins and antimicrobial agents. In humans, many diseases,
Amy L, Davidson, Jue, Chen
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ATP‐binding cassette transporters and cholesterol translocation
IUBMB Life, 2013AbstractCholesterol, a major component of mammalian cell membranes, plays important structural and functional roles. However, accumulation of excessive cholesterol is toxic to cells. Aberrant cholesterol trafficking and accumulation is the molecular basis for many diseases, such as atherosclerotic cardiovascular disease and Tangier's disease ...
Ge, Li, Hong-Mei, Gu, Da-Wei, Zhang
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ATP-binding cassette (ABC) transporters in atherosclerosis
Current Atherosclerosis Reports, 2002Macrophages play a central role in the initiation and progression of atherosclerotic lesions. In the nascent lesion, macrophages transform into foam cells through the excessive accumulation of cholesteryl esters. Dysfunctional lipid homeostasis in macrophages and foam cells ultimately results in the breakdown of membrane integrity and cell death ...
Gerd, Schmitz, Wolfgang E, Kaminski
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Plant ATP-Binding Cassette Transporters
Annual Review of Plant Biology, 2007The ATP-binding cassette (ABC) protein superfamily is one of the largest known, with over 120 members in both Arabidopsis thaliana and rice (Oryza sativa). Most, but not all, ABC proteins are modularly organized membrane proteins (“ABC transporters”) that mediate MgATP-energized transmembrane transport and/or regulate other transporters.
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Evolution of ATP-binding cassette transporter genes
Current Opinion in Genetics & Development, 1995The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found ...
M, Dean, R, Allikmets
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The Genetics of ATP‐Binding Cassette Transporters
2005The ATP-binding cassette (ABC) superfamily consists of membrane proteins that transport a wide variety of substrates across membranes. Mutations in ABC transporters cause or contribute to a number of different Mendelian disorders, including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, cholesterol, and bile transport defects. In addition,
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