Results 251 to 260 of about 156,745 (364)

The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein. [PDF]

Int J Mol Sci, 2020
Mello FVC, de Moraes GN, Maia RC, Kyeremateng J, Iram SH, Santos-Oliveira R.   +5 more
europepmc   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Promising prognostic value of ATP binding cassette transporters and their correlation with tumor-infiltrating immune cells in lung adenocarcinoma. [PDF]

Genes Dis
Wei L, Yu Q, Yang X.
europepmc   +1 more source

Trapping the transition state of an ATP-binding cassette transporter: Evidence for a concerted mechanism of maltose transport

, 2001
J. Chen
openalex   +1 more source

Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis [PDF]

, 2002
Baisakhee Saha Choudhuri, Sanjib Bhakta, Rajib Barik, Joyoti Basu, Manikuntala Kundu, Parul Chakrabarti   +5 more
openalex   +1 more source

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, EarlyView.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source

An ATP-Binding Cassette Transporter and Two rRNA Methyltransferases Are Involved in Resistance to Avilamycin in the Producer Organism Streptomyces viridochromogenes Tü57

, 2001
Gabriele Weitnauer, Sibylle Gaisser, Axel Trefzer, Sigrid Stockert, Lucy Westrich, Luís M. Quirós, Cármen Méndez, José A. Salas, Andreas Bechthold   +8 more
openalex   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source

Msp1 and Pex19‐Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes

The FEBS Journal, EarlyView.
In this study, we analyzed how the dual‐localized AAA‐ATPase Msp1 handles Pex15. We show that newly synthesized Pex15 is primarily targeted to peroxisomes via the Pex19‐Pex3 pathway. Mitochondrial Msp1 extracts mistargeted Pex15, which is either sent to the ER via the GET pathway for degradation or redirected to peroxisomes via the Pex19‐Pex3 ...
Shunsuke Matsumoto, Yoshiki Kogure, Suzuka Ono, Tomoyuki Numata, Toshiya Endo   +4 more
wiley   +1 more source

Candida glabrata ATP-binding Cassette Transporters Cdr1p and Pdh1p Expressed in aSaccharomyces cerevisiae Strain Deficient in Membrane Transporters Show Phosphorylation-dependent Pumping Properties [PDF]

, 2002
Shun‐ichi Wada, Masakazu Niimi, Kyoko Niimi, Ann R. Holmes, Brian C. Monk, Richard D. Cannon, Yoshimasa Uehara   +6 more
openalex   +1 more source