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The Genetics of ATP‐Binding Cassette Transporters

2005
The ATP-binding cassette (ABC) superfamily consists of membrane proteins that transport a wide variety of substrates across membranes. Mutations in ABC transporters cause or contribute to a number of different Mendelian disorders, including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, cholesterol, and bile transport defects. In addition,
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Interrelationship between ATP-binding cassette transporters and oxysterols

Biochemical Pharmacology, 2013
ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of membrane proteins responsible for the translocation of several substances across membranes using the chemical energy provided by ATP hydrolysis. ABC transporters participate in many physiological and pathophysiological processes, including cholesterol and lipid ...
Jorge L M, Ruiz   +3 more
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Hepatocellular Transport: Role of ATP-Binding Cassette Proteins

Seminars in Liver Disease, 1996
The interest of mammalian biologists in ATP-binding cassette (ABC) proteins is relatively recent. However, ABC proteins are widespread in distribution and have long been known to play an important transport role in prokaryotes. The review includes a brief overview of the structure, regulation, and varied functions of ABC proteins in different cell ...
N, Lomri, J G, Fitz, B F, Scharschmidt
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ATP-binding cassette transporter A1 and cholesterol trafficking

Current Opinion in Lipidology, 2002
Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway.
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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Advanced Drug Delivery Reviews, 2003
Alfred H Schinkel, Johan W Jonker
exaly  

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Advanced Drug Delivery Reviews, 2012
Alfred H Schinkel, Johan W Jonker
exaly  

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