Results 71 to 80 of about 156,745 (364)

Bacterial Community in Cold Surge-Caused Sea Ice Differs From Seawater in Mid-Latitude Region: A Case Study in Aoshan Bay, Southern Yellow Sea

Frontiers in Marine Science, 2022
Cold surges result in a rapid drop in air temperature and freezing of seawater, which was likely to impact bacterial communities. We examined the differences in bacteria abundance and bacterial community composition in the sea ice and seawater during a ...
Hongwei Ren, Hongwei Ren, Jihua Liu, Jihua Liu, Jihua Liu, Gang Li, Yubin Hu, Yubin Hu   +7 more
doaj   +1 more source

ATP-Binding Cassette Efflux Transporters in Human Placenta [PDF]

Current Pharmaceutical Biotechnology, 2011
Pregnant women are often complicated with diseases including viral or bacterial infections, epilepsy, hypertension, or pregnancy-induced conditions such as depression and gestational diabetes that require treatment with medication. In addition, substance abuse during pregnancy remains a major public health problem. Many drugs used by pregnant women are
Zhanglin Ni, Qingcheng Mao
openaire   +3 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain. [PDF]

PLoS ONE, 2017
ATP-binding cassette (ABC) transporters form a large family of transmembrane importers and exporters. Using two nucleotide-binding domains (NBDs), which form a canonical ATP-sandwich dimer at some point within the transport cycle, the transporters ...
Ahmet S Vakkasoglu, Sriram Srikant, Rachelle Gaudet   +2 more
doaj   +1 more source

Structural and functional diversity calls for a new classification of ABC transporters [PDF]

, 2020
Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane ...
Aller, Stephen G, Beis, Konstantinos, Carpenter, Elisabeth P, et al, Martinoia, Enrico, Thomas, Christoph   +5 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

The size of the immune repertoire of bacteria [PDF]

, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past infections. The typical cassette contains a few dozen spacers.
arxiv   +1 more source

Broadband and efficient diffraction [PDF]

Advanced Optical Material 1, 489-493 (2013), 2013
Surface topography dictates the deterministic functionality of diffraction by a surface. In order to maximize the efficiency with which a diffractive optical component, such as a grating or a diffractive lens, directs light into a chosen order of diffraction, it is necessary that it be "blazed".
arxiv   +1 more source

Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum [PDF]

, 2014
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf ...
Goossens, Alain, Hayashida, Minaho, Ito, Shingo, Minami, Shota, Morita, Masahiko, Moriyama, Yoshinori, Moriyasu, Masataka, Omote, Hiroshi, Shitan, Nobukazu, Sugiyama, Akifumi, Takanashi, Kojiro, Yazaki, Kazufumi   +11 more
core   +7 more sources

Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways. [PDF]

, 2015
URAT1 (slc22a12) was identified as the transporter responsible for renal reabsorption of the medically important compound, uric acid. However, subsequent studies have indicated that other transporters make contributions to this process, and that URAT1 ...
Eraly, Satish A, Jamshidi, Neema, Liu, Henry C, Nigam, Sanjay K   +3 more
core   +2 more sources