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Pain Practice, 2002
Many decades have passed since the pain-producing properties of ATP were demonstrated in both animals and humans. However, the more recent discovery of a family of ion channels for which ATP is a ligand and which are expressed by nociceptive neurons, has led to a resurgence of interest into the physiological and pathophysiological actions of ATP.
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Many decades have passed since the pain-producing properties of ATP were demonstrated in both animals and humans. However, the more recent discovery of a family of ion channels for which ATP is a ligand and which are expressed by nociceptive neurons, has led to a resurgence of interest into the physiological and pathophysiological actions of ATP.
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Current Opinion in Neurobiology, 1994
ATP receptors continue to be found in an ever wider range of tissues in the brain and the periphery. Much of the recent research on these receptors focuses on features that would distinguish ATP-mediated excitatory synaptic transmission from that mediated through glutamate or acetylcholine receptors.
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ATP receptors continue to be found in an ever wider range of tissues in the brain and the periphery. Much of the recent research on these receptors focuses on features that would distinguish ATP-mediated excitatory synaptic transmission from that mediated through glutamate or acetylcholine receptors.
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ATP and the pathogenesis of COPD
European Journal of Pharmacology, 2010Extracellular ATP is a signalling molecule that often serves as a danger signal to alert the immune system of tissue damage. This molecule activates P2 nucleotide receptors, that include the ionotropic P2X receptors and the metabotropic P2Y receptors. Several publications highlight the importance of purinergic signalling in the pathogenesis of chronic ...
Paul A.J. Henricks +3 more
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ATP-Stimulated Release of ATP by Human Endothelial Cells
Journal of Cardiovascular Pharmacology, 1996We investigated the effects of several concentrations of extracellular ATP on the release of intracellular ATP by human umbilical vein endothelial cells (HUVEC) in primary cultures. When ATP is added to the medium of cultured EC at a concentration of 1 microM, it is readily degraded by extracellular enzymes; 10 microM ATP added to the culture medium ...
Philippe Bodin, Geoffrey Burnstock
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Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 for ATP Imaging in Live Cells.
Journal of the American Chemical Society, 2017Zeolitic imidazole frameworks (ZIFs) are an emerging class of functional porous materials with promising biomedical applications such as molecular sensing and intracellular drug delivery.
Jingjing Deng +4 more
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Photosynthesis Research, 2004
The machinery of life has been disclosed in the second half of the 20th century to a degree not in the least envisioned previously by even the most daring players in this field. It has been extremely rewarding to start out from the fogs and to enjoy the brightness at the end of one's active career.
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The machinery of life has been disclosed in the second half of the 20th century to a degree not in the least envisioned previously by even the most daring players in this field. It has been extremely rewarding to start out from the fogs and to enjoy the brightness at the end of one's active career.
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Unexpectedly General Replaceability of ATP in ATP-Requiring Enzymes
Journal of Biochemistry, 1997ATP-dependent enzymes were investigated as to the stringency of their ATP requirement. For all the enzymes examined except firefly luciferase (including hexokinase, polynucleotide kinase, T4 DNA ligase, and T4 RNA ligase) ATP could be replaced with dATP, contradicting previous data.
Koichi Nishigaki, Yasunori Kinoshita
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The ATP synthase--a splendid molecular machine.
Annual Review of Biochemistry, 1997An X-ray structure of the F1 portion of the mitochondrial ATP synthase shows asymmetry and differences in nucleotide binding of the catalytic beta subunits that support the binding change mechanism with an internal rotation of the gamma subunit.
P. Boyer
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Interactions of caged-ATP and photoreleased ATP with alkaline phosphatase
Biochemical and Biophysical Research Communications, 2005Photolytic release of ATP from inactive P(3)-[1-(2-nitrophenyl)]ethyl ester of ATP (NPE-caged ATP) provides a means to reveal molecular interactions between nucleotide and enzyme by using infrared spectroscopy. Reaction-induced infrared difference spectra of bovine intestinal alkaline phosphatase (BIAP) and of NPE-caged ATP revealed small structural ...
Gérard Azzar, Le Zhang, René Buchet
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Enzymatic hydrolysis of ATP and e-ATP by F-actin
Journal of Bioenergetics and Biomembranes, 1976Enzymatic hydrolysis of e-ATP by F-actin with and without application of sonic vibration at various pHs was investigated and compared with that of ATP. There was no significant difference on enzymatic activity between F-actin-bound e-ADP and F-actin-bound ADP. The hydrolysis rate of e-ATP under sonic vibration decreases monotonically with decreasing pH,
Hiroshi Asai, M. Asai
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