Results 101 to 110 of about 8,657 (242)

ATP7B-maintained copper stores in myeloid progenitors are required for functional maturation of neutrophils

Cell Reports
Summary: Copper (Cu) is essential for innate immunity; however, how neutrophils regulate Cu homeostasis to support their functions remains unclear. We found that myeloid progenitors express abundant Cu-transporter ATP7B targeted to distinct vesicles and ...
Som Dev, Yu Wang, Moonjung Jung, Yingze Ma, Sepehr Mani, Ekaterina Kabin, Ridzky Yuda, Yixuan Dong, Martina Ralle, James P. Hamilton, Svetlana Lutsenko   +10 more
doaj   +1 more source

Identification and characterization of a novel 43-bp deletion mutation of the ATP7B gene in a Chinese patient with Wilson’s disease: a case report

BMC Medical Genetics, 2018
Background Wilson’s disease (WD) is an autosomal recessive disorder characterized by copper accumulation. ATP7B gene mutations lead to ATP7B protein dysfunction, which in turn causes Wilson’s disease. Case presentation We describe a male case of Wilson’s
Gang Liu, Dingyuan Ma, Jian Cheng, Jingjing Zhang, Chunyu Luo, Yun Sun, Ping Hu, Yuguo Wang, Tao Jiang, Zhengfeng Xu   +9 more
doaj   +1 more source

Histological features of liver disease development in the Atp7b^−/− mouse: a model of Wilson’s disease [PDF]

, 2023
Pierre‐Marie Lavrut, Olivier Guillaud, Jérôme Dumortier, Elisabeth Mintz, Virginie Brun, Sophie Heissat, Eduardo Couchonnal, Alain Lachaux, Muriel Bost, Valérie Hervieu   +9 more
openalex   +1 more source

Hepatocyte Transplantation in the Long Evans Cinnamon Rat Model of Wilson's Disease

Cell Transplantation, 2006
Wilson's disease (WD), caused by a mutation in the P-type copper transporting ATPase (Atp7b) gene, results in excessive accumulation of copper in the liver.
Seon Mee Park, Kim Vo, Michel Lallier, Alexis-Simon Cloutier, Pierre Brochu, Fernando Alvarez, Steven R. Martin   +6 more
doaj   +1 more source

Simulation of Copper-Dependent Regulation Dynamics in ATP7B [PDF]

, 2021
Fredrik Orädd, Magnus Andersson
openalex   +1 more source

ATP7b gene and Wilson's disease [PDF]

Journal of Gastroenterology and Hepatology, 2004
S Santhosh, RV Shaji, CE Eapen, GM Chandy   +3 more
openaire   +2 more sources

Glide Docking for Prediction of Potential Inhibitors of ATP7B Protein in Wilson Disease [PDF]

Journal of Advanced Biomedical Sciences
Background & Objectives: Wilson’s disease is a genetic disorder marked by the pathological accumulation of copper in the liver and brain due to malfunctioning of the ATP7B protein.
Monir Shalbafan, Mahdieh Sadeghpour, Abolfazl Olyaei   +2 more
doaj  

Biliary excretion of copper in LEC rat after introduction of copper transporting P‐type ATPase, ATP7B [PDF]

, 1999
Kunihiko Terada, Namiko Aiba, Xiaoli Yang, Masatake Iida, Michio Nakai, Naoyuki Miura, Toshihiro Sugiyama   +6 more
openalex   +1 more source

Data from Therapeutic Targeting of ATP7B in Ovarian Carcinoma

, 2023
Lingegowda S. Mangala, Vesna Zuzel, Rosemarie Schmandt, Erik S LeShane, Jyotsna B. Halder, Guillermo N. Armaiz-Peña, Whitney A. Spannuth, Takemi Tanaka, Mian M.K. Shahzad, Yvonne G. Lin, Alpa M. Nick, Christopher G. Danes, Jeong‐Won Lee, Nicholas B. Jennings, Pablo E. Vivas‐Mejía, Judith K. Wolf, Robert L. Coleman, Zahid H. Siddik, Gabriel Lopez‐Berestein, Svetlana Lutsenko, Anil K. Sood   +20 more
openalex   +1 more source

小鼠肝脏特异性表达载体ALB-ATP7B的构建

Zhongshan Daxue xuebao. Yixue kexue ban, 2004
［目的 l 构建人肝豆状核变性病ATP7B基因野生型及常见突变型的小鼠肝脏特异性表达载体 ALB-ATP7B, 为制备转基因小鼠及相关基因治疗作准备。【方法】定点突变法获取人群中常见的Arg778Leu及 Hisl069Gln两种ATP7B基因突变体，定向克隆将小鼠白蛋白启动子ALB序列及野生和突变的ATP7B基因亚克 隆至真核表达载体kbpala上， 得到可在小鼠肝脏特异性表达的人ATP7B基因正常及突变型真核表达载体 ALB-ATP7B。【结果】经测序及酶切鉴定证实， 真核表达载体ALB ...
doaj