Results 211 to 220 of about 8,657 (242)

ATP7B (WND) protein

The International Journal of Biochemistry & Cell Biology, 1998
Wilson's disease is a genetic disorder of copper metabolism characterized by the excessive accumulation of this metal in the liver. The gene for Wilson's disease, designated ATP7B, encodes a copper transporting P-type ATPase expressed predominantly in the liver.
K, Terada, M L, Schilsky, N, Miura, T, Sugiyama   +3 more
openaire   +2 more sources

Polarized trafficking and copper transport activity of ATP7B: A mutational approach to establish genotype–phenotype correlation in Wilson disease

Human Mutation, 2022
Mutation in ATP7B gene causes Wilson disease (WD) that is characterized by severe hepatic and neurological symptoms. ATP7B localizes at the trans‐Golgi Network (TGN) transporting copper to copper‐dependent enzymes and traffics in apically targeted ...
Santanu Das, Ameena Mohammed, T. Mandal, Saptarshi Maji, Jay Verma, Ruturaj, Arnab Gupta   +6 more
semanticscholar   +1 more source

Epigallocatechin Gallate Promotes Cuproptosis via the MTF1/ATP7B Axis in Hepatocellular Carcinoma

Cells
Background: Cuproptosis is a form of copper-dependent non-apoptotic cell death. Cancer cells that prefer to use aerobic glycolysis for energy generation are commonly insensitive to cuproptosis, which hinders its application for cancer treatment ...
Yuhan Fu, Lirui Hou, Kai Han, Chong Zhao, Hongbo Hu, Shutao Yin   +5 more
semanticscholar   +1 more source

ATPase copper transporting beta (ATP7B) is a novel target for improving the therapeutic efficacy of docetaxel by disulfiram/copper in human prostate cancer.

Molecular Cancer Therapeutics
Docetaxel has been the standard first-line chemotherapy for lethal metastatic prostate cancer (mPCa) since 2004, but resistance to docetaxel treatment is common.
Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia, Christopher J. Chang, Edward Uchio, X. Zi   +6 more
semanticscholar   +1 more source

ATP7A, ATP7B, and RETN genotypes in Labrador Retrievers with and without copper-associated hepatopathy.

Journal of the American Veterinary Medical Association, 2022
OBJECTIVE To determine the frequency of previously reported coding variants in the ATP7A, ATP7B, and RETN genes in a US population of Labrador Retrievers and to explore potential associations of these genotypes with pathologic hepatic copper accumulation.
D. Langlois, Brendan S M Nagler, R. Smedley, Ya-Ting Yang, V. Yuzbasiyan-Gurkan   +4 more
semanticscholar   +1 more source

Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis.

Gastroenterology, 2019
BACKGROUND & AIMS Wilson disease (WD) is an inherited disorder of copper metabolism that leads to copper accumulation and toxicity in the liver and brain. It is caused by mutations in the adenosine triphosphatase copper transporting β gene (ATP7B), which
E. Polishchuk, A. Merolla, J. Lichtmannegger, Alessia Romano, A. Indrieri, E. Ilyechova, Mafalda Concilli, Rossella De Cegli, R. Crispino, Marta Mariniello, R. Petruzzelli, G. Ranucci, R. Iorio, F. Pietrocola, Claudia Einer, S. Borchard, A. Zibert, H. Schmidt, Elia Di Schiavi, L. Puchkova, B. Franco, G. Kroemer, H. Zischka, R. Polishchuk   +23 more
semanticscholar   +1 more source

Neurological manifestations and ATP7B mutations in Wilson's disease

Parkinsonism & Related Disorders, 2008
Wilson's disease (WD) is a rare inborn metabolic error characterized by deficient biliary copper excretion secondary to ATP7B gene mutations. Neurological presentations are variable in respect to both pattern and age of onset; commonly a movement disorder presents in the second or third decade.
Alexandre Aluizio Costa, Machado, Marta Mitiko, Deguti, Janine, Genschel, Eduardo Luiz Rachid, Cançado, Bettina, Bochow, Hartmut, Schmidt, Egberto Reis, Barbosa   +6 more
openaire   +2 more sources

Overexpressed ATP7B protects mesenchymal stem cells from toxic copper

Biochemical and Biophysical Research Communications, 2010
Wilson's disease (WD) is characterized by accumulation of high levels of copper in liver due to malfunction of copper transporter ATP7B which is central for copper homeostasis. Here we report for the first time that mesenchymal stem cells (MSC) derived from bone marrow express detectable levels of ATP7B.
Vanessa, Sauer, Ramsi, Siaj, Theodor, Todorov, Andree, Zibert, Hartmut H-J, Schmidt   +4 more
openaire   +2 more sources

ATP7B Gene Mutations in Croatian Patients with Wilson Disease

Genetic Testing and Molecular Biomarkers, 2016
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism, characterized by its accumulation in tissues which results in hepatic, neurological, and/or psychiatric symptoms. The aim of this study was to investigate the genetics of WD in Croatian patients.Correlation of the clinical presentation subtype and the age at onset of the ...
Ljubić Hana, Kalauz Mirjana, Telarović Srđana, Ferenci Peter, Ostojić Rajko, Noli Maria Cristina, Lepori Maria Barbara, Hrstić Irena, Vuković Jurica, Premužić Marina, Radić Davor, Grubelić Ravić Katja, Sertić Jadranka, Merkler Ana, Acman Barišić Ana, Loudianos Georgios, Vucelić Boris   +16 more
openaire   +4 more sources

Transport of Cisplatin by the Copper Efflux Transporter ATP7B

Molecular Pharmacology, 2008
ATP7B is a P-type ATPase that mediates the efflux of copper. Recent studies have demonstrated that ATP7B regulates the cellular efflux of cisplatin (DDP) and controls sensitivity to the cytotoxic effects of this drug. To determine whether DDP is a substrate for ATP7B, DDP transport was assayed in vesicles isolated from Sf9 cells infected with a ...
Roohangiz, Safaei, Shinji, Otani, Barrett J, Larson, Michael L, Rasmussen, Stephen B, Howell   +4 more
openaire   +2 more sources