Results 21 to 30 of about 8,657 (242)

Regulation of murine copper homeostasis by members of the COMMD protein family

Disease Models & Mechanisms, 2021
Copper is an essential transition metal for all eukaryotes. In mammals, intestinal copper absorption is mediated by the ATP7A copper transporter, whereas copper excretion occurs predominantly through the biliary route and is mediated by the paralog ATP7B.
Amika Singla, Qing Chen, Kohei Suzuki, Jie Song, Alina Fedoseienko, Melinde Wijers, Adam Lopez, Daniel D. Billadeau, Bart van de Sluis, Ezra Burstein   +9 more
doaj   +1 more source

Combination of the cuproptosis inducer disulfiram and anti-PD-L1 abolishes NSCLC resistance by ATP7B to regulate the HIF-1 signaling pathway

International Journal of Molecular Medicine, 2023
Disulfiram (DSF) is used to treat non-small cell lung cancer (NSCLC). DSF significantly increases expression of programmed death-ligand 1 (PD-L1), which may enhance immunosuppression and immune escape of tumors.
Pengfei Li, Qi Sun, Shuping Bai, Haitao Wang, Ling Zhao   +4 more
semanticscholar   +1 more source

Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B

Journal of Cell Science, 2023
The homologous P-type copper-ATPases (Cu-ATPases) ATP7A and ATP7B are the key regulators of copper homeostasis in mammalian cells. In polarized epithelia, upon copper treatment, ATP7A and ATP7B traffic from the trans-Golgi network (TGN) to basolateral ...
Ruturaj, Monalisa Mishra, Soumyendu Saha, Saptarshi Maji, Enrique Rodriguez-Boulan, Ryan Schreiner, Arnab Gupta   +6 more
semanticscholar   +1 more source

ATP7B R778L mutant hepatocytes resist copper toxicity by activating autophagy and inhibiting necroptosis

Cell Death Discovery, 2023
Wilson’s disease (WD) is an inherited disease characterized by copper metabolism disorder caused by mutations in the adenosine triphosphatase copper transporting β gene (ATP7B). Currently, WD cell and animal model targeting the most common R778L mutation
Shan Tang, Chen Liang, Wei Hou, Zhongjie Hu, Xinyue Chen, Jing Zhao, Wei Zhang, Zhongping Duan, L. Bai, Sujun Zheng   +9 more
semanticscholar   +1 more source

Mutation spectrum of ATP7B gene in pediatric patients with Wilson disease in Vietnam

Molecular Genetics and Metabolism Reports, 2022
Background: Wilson disease (WD) is caused by mutations in the copper-transporting P-type adenosine triphosphatase encoded by the ATP7B gene. In this study, we screened and identified the ATP7B mutations among unrelated Vietnamese pediatric patients ...
Nguyen Thi Mai Huong, Nguyen Pham Anh Hoa, Ngo Diem Ngoc, Nguyen Thi Phuong Mai, Pham Hai Yen, Hoàng Thị Vân Anh, Giang Hoa, Tran Minh Dien   +7 more
doaj   +1 more source

Cuproptosis-Related Gene – SLC31A1, FDX1 and ATP7B – Polymorphisms are Associated with Risk of Lung Cancer

Pharmacogenomics and Personalized Medicine, 2022
Background Cuproptosis is a novel copper-dependent cell death, and the copper level was increased in lung cancer patients. However, few studies evaluated the association between single-nucleotide polymorphisms (SNPs) in cuproptosis-related genes and lung
Yuhui Yun, Yun Wang, Ende Yang, X. Jing
semanticscholar   +1 more source

Stimulation of Liver Fibrosis by N2 Neutrophils in Wilson’s DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Wilson’s disease is an inherited hepatoneurologic disorder caused by mutations in the copper transporter ATP7B. Liver disease from Wilson’s disease is one leading cause of cirrhosis in adolescents. Current copper chelators and zinc
Xiaoxiao Mi, Yu Song, Chaohua Deng, Jian Yan, Zhihui Li, Yingniang Li, Jun Zheng, Wenjun Yang, Ling Gong, Junping Shi   +9 more
doaj   +1 more source

Wilson’s Disease with Neurological Presentation, without Hepatic Involvement in Two Siblings [PDF]

Journal of Clinical and Diagnostic Research, 2013
Wilson’s Disease (WD) is a rare, autosomal, recessive, inborn error of the copper metabolism, which is caused by a mutation in the copper-transporting gene, ATP7B. The presentation is usually neurologic or hepatic, which is seen in 40% of the patients.
Mani Kant Kumar, Vijay Kumar, Praphul Kumar Singh   +2 more
doaj   +1 more source

ROLUL PROTEINEI ATP7B ÎN HOMEOSTAZIA CUPRULUI ȘI ÎN DEZVOLTAREA BOLII WILSON: REVISTA LITERATURII

Arta Medica, 2022
Obiective. Scopul lucrării prezente constă în studierea funcției proteinei ATP7B la nivel celular și sistemic, implicarea enzimei în menținerea echilibrului intern al ionilor de cupru, precum și rolul ei în dezvoltarea maladiei Wilson.
Veronica Cumpătă
doaj   +1 more source

Identification of Lncrna-Mrna Networks in Hepg2 Cells upon ATP7B Knockout and Copper Accumulation

Iranian Journal of Public Health, 2023
Background: Hepatolenticular degeneration (HLD) is an inherited disorder caused by the mutation in the adenosine triphosphatase copper transporting β gene (ATP7B). W aimed to explore the genetic changes in HLD using bioinformatics analysis.
Yan Yan, Yin Xu, Lin Chen, Yongzhu Han, Renmin Yang, Wenbin Hu   +5 more
semanticscholar   +1 more source