Results 211 to 220 of about 58,467 (240)

Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters. [PDF]

Cancer Drug Resist
Roth JS, Guo H, Chen L, Shen M, Gbadegesin O, Robey RW, Gottesman MM, Hall MD.   +7 more
europepmc   +1 more source

Identification of novel drug-specific PARP inhibitor resistance mechanisms in ovarian cancer-implications for clinical practice. [PDF]

Br J Cancer
Macdonald CJ, McWhirter A, Vaidyanathan A, Ferguson MJ, Eberl HC, Stronach EA, Sawers L, Smith G.   +7 more
europepmc   +1 more source

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2-Positive Cancers. [PDF]

Cancer Sci
Murase Y, Nanjo S, Arai S, Kondo S, Koba H, Liu Y, Fukuda K, Sato S, Kinoshita J, Inaki N, Ueda T, Nomura S, Tambo Y, Shimizu T, Horie M, Maeda D, Wong RW, Hosomichi K, Kobayashi T, Watanabe S, Yamamura K, Ohkura N, Abo M, Yano S.   +23 more
europepmc   +1 more source

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ATP-Binding Cassette Transporter C4 is a Prostaglandin D2 Exporter in HMC-1 cells

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2020
ATP-binding cassette transporter C4 (ABCC4) is associated with multidrug resistance and the regulation of cell signalling. Some prostaglandins (PGs), including: PGE2, PGF2α, PGE3, and PGF3α are known substrates of ABCC4, and are released from some types of cells to exert their biological effects.
Nobuaki, Tanaka, Junya, Kawai, Noriyasu, Hirasawa, Nariyasu, Mano, Hiroaki, Yamaguchi   +4 more
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The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Nature Genetics, 1999
Tangier disease (TD) is an autosomal recessive disorder of lipid metabolism. It is characterized by absence of plasma high-density lipoprotein (HDL) and deposition of cholesteryl esters in the reticulo-endothelial system with splenomegaly and enlargement of tonsils and lymph nodes.
M, Bodzioch, E, Orsó, J, Klucken, T, Langmann, A, Böttcher, W, Diederich, W, Drobnik, S, Barlage, C, Büchler, M, Porsch-Ozcürümez, W E, Kaminski, H W, Hahmann, K, Oette, G, Rothe, C, Aslanidis, K J, Lackner, G, Schmitz   +16 more
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Interaction of angiotensin receptor type 1 blockers with ATP‐binding cassette transporters

Biopharmaceutics & Drug Disposition, 2010
AbstractATP‐binding cassette (ABC)‐transporters, such as P‐glycoprotein (P‐gp/ABCB1), multidrug resistance‐associated proteins (MRPs/ABCCs) and breast cancer resistance protein (BCRP/ABCG2) transport numerous drugs thus regulating their absorption, distribution and excretion.
J, Weiss, A, Sauer, N, Divac, M, Herzog, E, Schwedhelm, R H, Böger, W E, Haefeli, R A, Benndorf   +7 more
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Structural snapshot of the cholesterol-transport ATP-binding cassette proteins 1.

Biochemistry and cell biology = Biochimie et biologie cellulaire, 2019
The ATP-binding cassette (ABC) proteins play critical roles in maintaining lipid and sterol homeostasis in higher eukaryotes. In humans, several subfamily-A and -G members function as cholesterol transporters across the cellular membranes. Deficiencies of these ABC proteins can cause dyslipidemia that is associated with health conditions such as ...
Bala M, Xavier, William J, Jennings, Aiman A, Zein, Junmei, Wang, Jyh-Yeuan, Lee   +4 more
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Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Nature Genetics, 1999
Tangier disease (TD) was first discovered nearly 40 years ago in two siblings living on Tangier Island. This autosomal co-dominant condition is characterized in the homozygous state by the absence of HDL-cholesterol (HDL-C) from plasma, hepatosplenomegaly, peripheral neuropathy and frequently premature coronary artery disease (CAD).
S, Rust, M, Rosier, H, Funke, J, Real, Z, Amoura, J C, Piette, J F, Deleuze, H B, Brewer, N, Duverger, P, Denèfle, G, Assmann   +10 more
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Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model

Biochemical and Biophysical Research Communications, 2014
P-glycoprotein (P-gp, product of Mdr1a and Mdr1b genes), multidrug resistance associated proteins (Mrps), and breast cancer resistance protein (Bcrp), all members of the ATP-binding cassette (ABC) membrane-associated drug transporters superfamily, can significantly restrict the entry of antiretroviral drugs (ARVs) into organs which exhibit a barrier ...
Kevin R, Robillard, Md Tozammel, Hoque, Reina, Bendayan   +2 more
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Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux

Cardiovascular & Hematological Disorders-Drug Targets, 2014
Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
openaire   +2 more sources