Results 231 to 240 of about 40,880 (280)

ATP-binding cassette transporter A1 and cholesterol trafficking

Current Opinion in Lipidology, 2002
Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway.
J. Oram
semanticscholar   +3 more sources

Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis

Current Opinion in Lipidology, 2005
The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development ...
M. Eck, M. Pennings, M. Hoekstra, Ruud Out, T. V. van Berkel   +4 more
semanticscholar   +3 more sources

Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts

Biochemical and Biophysical Research Communications, 2003
The ATP-binding cassette transporter A1 (ABCA1) gene, a major regulator of high-density lipoprotein (HDL) metabolism, utilizes several transcriptional start sites. The pattern of transcripts among tissues and cells differed significantly. The longest (class 1) transcripts were abundant in adult brain and fetal tissues.
Jarkko, Huuskonen, Monika, Abedin, Meeta, Vishnu, Clive R, Pullinger, Sergio E, Baranzini, John P, Kane, Phoebe E, Fielding, Christopher J, Fielding   +7 more
openaire   +2 more sources

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages

Biochemical and Biophysical Research Communications, 2004
The ATP-binding-cassette transporter A1 (ABCA1) plays an essential role in cellular cholesterol efflux and helps prevent macrophages from becoming foam cells. The statins are widely used as cholesterol-lowering agents and have other anti-atherogenic actions.
Hirohito, Sone, Hitoshi, Shimano, Miao, Shu, Masanori, Nakakuki, Akimitsu, Takahashi, Masakazu, Sakai, Yuichiro, Sakamoto, Tomotaka, Yokoo, Ken, Matsuzaka, Hiroaki, Okazaki, Yoshimi, Nakagawa, Kaoruko Tada, Iida, Hiroaki, Suzuki, Hideo, Toyoshima, Seikoh, Horiuchi, Nobuhiro, Yamada   +15 more
openaire   +2 more sources

ATP-binding cassette transporter A1: regulation of cholesterol efflux

Biochemical Society Transactions, 2004
The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells. Mutations in ABCA1 give rise to familial high-density lipoprotein (HDL) deficiency and Tangier disease, which is characterized by very low levels of HDL in plasma and cholesteryl ester accumulation in tonsils and other reticuloendothelial ...
openaire   +2 more sources

Regulation of ATP-Binding Cassette Transporter A1 Transcription by Thyroid Hormone Receptor

Biochemistry, 2004
Transcriptional regulation of the ATP-binding cassette transporter (ABCA1) gene is complex. It involves multiple transcription start sites and the binding of several different transcription factors to the ABCA1 promoter region. Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and ...
Jarkko, Huuskonen, Meeta, Vishnu, Clive R, Pullinger, Phoebe E, Fielding, Christopher J, Fielding   +4 more
openaire   +2 more sources

ATP-binding cassette transporter A1, fatty acids, and cholesterol absorption

Current Opinion in Lipidology, 2003
A significant advance in our understanding of the reverse cholesterol transport pathway occurred in 1999 with the identification of defects in the ATP-binding cassette transporter A1 gene as the cause of Tangier disease. Since this discovery, an overwhelming number of experiments have been conducted to further define the function of this gene.
openaire   +2 more sources

ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion

The Journal of Nutritional Biochemistry, 2010
Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver.
Mototada, Shichiri, Yasukazu, Takanezawa, Daisy E, Rotzoll, Yasukazu, Yoshida, Tomokuni, Kokubu, Kazumitsu, Ueda, Hiroshi, Tamai, Hiroyuki, Arai   +7 more
openaire   +2 more sources

Effects of Pravastatin on the Expression of ATP-Binding Cassette Transporter A1

The Journal of Pharmacology and Experimental Therapeutics, 2004
In vitro inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase causes the suppression of liver X receptor (LXR) activity. Because LXR regulates the expression of ATP-binding cassette transporter (ABC) A1, which is involved in the high-density lipoprotein-related reverse cholesterol transport pathway, we examined the effects of an HMG ...
Hitoshi, Ando, Shuichi, Tsuruoka, Hisashi, Yamamoto, Toshinari, Takamura, Shuichi, Kaneko, Akio, Fujimura   +5 more
openaire   +2 more sources