Results 151 to 160 of about 29,839 (226)

The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis

Nature Communications
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear.
Wentao Zhao, Cong Ouyang, Liang Zhang, Jinyang Wang, Jiaojiao Zhang, Yan Zhang, Chen Huang, Qiao Xiao, Bin Jiang, Furong Lin, Cixiong Zhang, Mingxia Zhu, Changchuan Xie, Xi Huang, Bingchang Zhang, Wenpeng Zhao, Jiawei He, Sifang Chen, Xiyao Liu, Donghai Lin, Qinxi Li, Zhanxiang Wang   +21 more
doaj   +1 more source

Physiological significance of autocrine orexinergic signaling in extra‐hypothalamic tissues

Physiological Reports, Volume 14, Issue 8, April 2026.
Mechanisms of autocrine orexinergic effects in extra‐hypothalamic tissues. Abstract Orexin‐A and orexin‐B, originally discovered as hypothalamic neuropeptides, have been detected in extra‐hypothalamic tissues together with their receptors (OX1R and OX2R) since the early 2000s.
Jean Claude Hakizimana, Makinde Vincent Olubiyi, Abdullateef Isiaka Alagbonsi   +2 more
wiley   +1 more source

Clonal Stabilization Reveals a DAO/3MST‐Expressing MDCK Subpopulation With Robust d‐Cysteine‐Mediated H2S Production

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
A subpopulation of MDCK (NBL‐2) cells, an epithelial cell line derived from the normal kidney, expresses DAO and 3MST. The DAO/3MST‐expressing cells are progressively eliminated during passaging; however, clonal isolation enables the establishment of sublines that maintain stable H2S production. Clonal cells co‐expressing DAO and 3MST therefore provide
Akari Miyamoto, Haruna Ueno, Hideo Kimura, Tadashi Nakagawa, Norihiro Shibuya   +4 more
wiley   +1 more source

Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis. [PDF]

Proc Natl Acad Sci U S A, 2023
Puccini J, Wei J, Tong L, Bar-Sagi D.
europepmc   +1 more source

ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury. [PDF]

Cell Death Dis, 2023
Li R, Meng M, Chen Y, Pan T, Li Y, Deng Y, Zhang R, Tian R, Xu W, Zheng X, Gong F, Liu J, Tang H, Ding X, Tang Y, Annane D, Chen E, Qu H, Li L.   +18 more
europepmc   +1 more source

Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure-Activity Relationship and Inhibition Profiles. [PDF]

Int J Mol Sci, 2022
Wang P, Hou T, Xu F, Luo F, Zhou H, Liu F, Xie X, Liu Y, Wang J, Guo Z, Liang X.   +10 more
europepmc   +1 more source

ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model. [PDF]

Front Endocrinol (Lausanne), 2022
Zhan Z, Li A, Zhang W, Wu X, He J, Li Z, Li Y, Sun J, Zhang H.   +8 more
europepmc   +1 more source

The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase. [PDF]

Acta Crystallogr F Struct Biol Commun, 2022
Huang J, Fraser ME.
europepmc   +1 more source

Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells. [PDF]

PLoS One, 2022
Hatipoglu A, Menon D, Levy T, Frias MA, Foster DA.   +4 more
europepmc   +1 more source

Cholinergic Phenotypes of Acetyl-CoA with ATP-Citrate Lyase Link. [PDF]

Int J Mol Sci
Gul-Hinc S, Jankowska-Kulawy A, Szutowicz A.   +2 more
europepmc   +1 more source