Results 1 to 10 of about 30,539 (256)
Dietary Citrus Peel Supplementation Enhances Hepatic Energy Metabolism, Muscle 9-HODE Generation and Isoleucine Catabolism in Beef Cattle [PDF]
MetabolitesBackground: Citrus components potentially suppress adipogenic differentiation and lipid accumulation, and exhibit anti-inflammatory and antioxidant effects. We hypothesized that the bioactive compounds in Citrus junos Sieb ex Tanaka (yuzu) fruit peel can
Susumu Muroya +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 ATP-citrate lyase (ACLY) is a key enzyme provoking metabolic and epigenetic gene regulation. Molecularly, these functions are exerted by the provision of acetyl-coenzyme A, which is then used as a substrate for de novo lipogenesis or as an acetyl-group ...
M. Dominguez +4 more
semanticscholar +1 more source
Nature Immunology, 2023 Unlike metabolic reprogramming that is characteristic of macrophage inflammatory polarization responses to lipopolysaccharide and TLR4 stimulation, the metabolism underlying inflammatory responses to CD40 signaling is not well characterized.
Pu-Ste Liu +11 more
semanticscholar +1 more source
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Antioxidants, 2021 Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux
P. Bradshaw
semanticscholar +1 more source
Bempedoic Acid: for Whom and When
Current Atherosclerosis Reports, 2022 The aim of creating an orally active non-statin cholesterol-lowering drug was achieved with bempedoic acid, a small linear molecule providing both a significant low-density lipoprotein cholesterol (LDL-C) reduction and an anti-inflammatory effect by ...
M. Ruscica +4 more
semanticscholar +1 more source
Current Issues in Molecular Biology, 2023 Citrus (Citrus reticulata) is one of the world’s most widely planted and highest-yielding fruit trees. Citrus fruits are rich in a variety of nutrients. The content of citric acid plays a decisive role in the flavor quality of the fruit.
Tian-ye Chen +6 more
semanticscholar +1 more source
Metabolic routes in inflammation: the citrate pathway and its potential as therapeutic target.
Current Medicinal Chemistry, 2020 Significant metabolic changes occur in inflammation to respond to the new energetic needs of cells. Mitochondria are addressed not only to produce ATP, but also to supply substrates, such citrate, to produce pro-inflammatory molecules.
V. Infantino, C. Pierri, V. Iacobazzi
semanticscholar +1 more source
Combined inhibition of ACLY and CDK4/6 reduces cancer cell growth and invasion
Oncology Report, 2022 The use of small molecule kinase inhibitors, which target specific enzymes that are overactive in cancer cells, has revolutionized cancer patient treatment. To treat some types of breast cancer, CDK4/6 inhibitors, such as palbociclib, have been developed
Brian C. Velez +6 more
semanticscholar +1 more source
Frontiers in Plant Science, 2023 Citric acid is the most important organic acid in melon and has a great influence on fruit flavor quality. ATP-citrate (pro-S) lyase (ACL) is a key regulator in the acetyl-CoA pathway and plays an important role in citric acid metabolism.
Kaili Ren, W. Kong, T. Tang, Hong Cheng
semanticscholar +1 more source
Identification of the Citrate-binding Site of Human ATP-Citrate Lyase Using X-ray Crystallography*
Journal of Biological Chemistry, 2010 ATP-citrate lyase (ACLY) catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, coupled with the hydrolysis of ATP. In humans, ACLY is the cytoplasmic enzyme linking energy metabolism from carbohydrates to the production of fatty ...
T. Sun +3 more
semanticscholar +1 more source