Results 201 to 210 of about 29,839 (226)
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Discovery of a Novel Macrocyclic ATP Citrate Lyase Inhibitor
Journal of Chemical Information and Modeling, 2022ATP citrate lyase (ACLY) is an important metabolic enzyme involved in the synthesis of fatty acid and cholesterol. The inhibition of ACLY is considered as a promising therapeutic strategy for various metabolic diseases and numerous malignancies. In this study, a novel macrocyclic compound 2 has been identified as a potent ACLY inhibitor with the "ring ...
Yongjun Zang +7 more
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On the Catalytic Mechanism of Human ATP Citrate Lyase
Biochemistry, 2012ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA). Studies were performed with recombinant human ACL to ascertain the nature of the catalytic phosphorylation that initiates the ACL reaction and the identity of the active site residues involved ...
Fan, Fan +9 more
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ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents
Recent Patents on Anti-Cancer Drug Discovery, 2012ATP citrate lyase (ACL or ACLY) is an extra-mitochondrial enzyme widely distributed in various human and animal tissues. ACL links glucose and lipid metabolism by catalyzing the formation of acetyl-CoA and oxaloacetate from citrate produced by glycolysis in the presence of ATP and CoA.
Xu-Yu, Zu +7 more
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Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders
Trends in Molecular Medicine, 2017Chronic overnutrition and a sedentary lifestyle promote imbalances in metabolism, often manifesting as risk factors for life-threating diseases such as atherosclerotic cardiovascular disease (ASCVD) and nonalcoholic fatty liver disease (NAFLD). Nucleocytosolic acetyl-coenzyme A (CoA) has emerged as a central signaling node used to coordinate metabolic ...
Stephen L, Pinkosky +3 more
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Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase
Trends in Pharmacological Sciences, 2019ATP-citrate lyase (ACLY) is an enzyme that links glycolysis to lipid metabolism. To date only partial X-ray structures of ACLY have been solved, thus limiting the design of novel inhibitors. Wei and colleagues (published online in Nature April 3, 2019) now report the full structure of human ACLY in complex with NDI-091143, revealing an appealing ...
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Role of ATP in the ATP citrate lyase reaction
Biochemical and Biophysical Research Communications, 1967H, Inoue +3 more
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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Cell Metabolism, 2022Battsetseg Batchuluun +2 more
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ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
Expert Opinion on Therapeutic Patents, 2022Carlotta Granchi
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ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review
Progress in Lipid Research, 2020Xiaojun Feng, Suo-wen Xu, Ai-Zong Shen
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